Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Johanna Jyrkkärinne"'
Autor:
Jenni Küblbeck, Toni Rönkkö, Björn Windshügel, Wolfgang Sippl, Paavo Honkakoski, Maija Lahtela-Kakkonen, Antti Poso, Anu J. Tervo, Johanna Jyrkkärinne
Publikováno v:
Journal of Medicinal Chemistry. 51:7181-7192
The human constitutive androstane receptor (CAR, NR1I3) is an important regulator of xenobiotic metabolism and other physiological processes. So far, only few CAR agonists are known and no explicit mechanism has been proposed for their action. Thus,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::389c73a1f59ec324e486757a56eaabd5
https://doi.org/10.1021/jm800731b
https://doi.org/10.1021/jm800731b
Autor:
Wolfgang Sippl, Björn Windshügel, Jenni Küblbeck, Johanna Jyrkkärinne, Paavo Honkakoski, Miia Turpeinen, Antti Poso
Publikováno v:
Biochemical Pharmacology. 76:1288-1297
The constitutive androstane receptor (CAR; NR1I3) is a nuclear receptor responsible for the recognition of potentially toxic endo- and exogenous compounds whose elimination from the body is accelerated by the CAR-mediated inducible expression of meta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bab584ead4f5df120a3f4193bb25f291
https://doi.org/10.1016/j.bcp.2008.08.014
https://doi.org/10.1016/j.bcp.2008.08.014
Autor:
Björn Windshügel, Paavo Honkakoski, Wolfgang Sippl, Johanna Jyrkkärinne, Jenni Vanamo, Antti Poso
Publikováno v:
Journal of Molecular Graphics and Modelling. 25:644-657
The constitutive androstane receptor (CAR) possesses an intrinsic basal activity whose structural basis has been analysed during the last decade. Recently, we published a homology model of the CAR ligand binding domain (LBD) based on the X-ray struct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8859770eda0e8b64cd01d694c42b35cf
https://doi.org/10.1016/j.jmgm.2006.05.002
https://doi.org/10.1016/j.jmgm.2006.05.002
Publikováno v:
Journal of Molecular Modeling. 11:69-79
The constitutive androstane receptor (CAR) belongs to the superfamily of nuclear-hormone receptors that function as ligand-activated transcription factors. CAR plays an essential role in the metabolism of xenobiotics and shows—in contrast to relate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bff1b8003ed3c99b019012aab33949e2
https://doi.org/10.1007/s00894-004-0227-4
https://doi.org/10.1007/s00894-004-0227-4
Publikováno v:
Drug metabolism and drug interactions. 28(2)
The constitutive androstane receptor (CAR; NR1I3) has emerged as one of the main drug- and xenobiotic-sensitive transcriptional regulators. It has a major effect on the expression of several oxidative and conjugative enzymes and transporters, and hen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74d6e0ff455143fe6c3fb1e234301552
https://pubmed.ncbi.nlm.nih.gov/23740682
https://pubmed.ncbi.nlm.nih.gov/23740682
Autor:
Tuomo Laitinen, Antti Poso, Paavo Honkakoski, Juha Pulkkinen, Reino Laatikainen, Jenni Küblbeck, Johanna Jyrkkärinne
Publikováno v:
Journal of chemical information and modeling. 52(2)
Constitutive androstane receptor (CAR), along with pregnane x receptor (PXR), is an important metabolic sensor in the hepatocytes. Like all other nuclear receptors (NRs), CAR works in concert with coregulator proteins, coactivators, and corepressors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2e6e8622ef2a69f05cd2aa5b7231fd5
https://pubmed.ncbi.nlm.nih.gov/22233089
https://pubmed.ncbi.nlm.nih.gov/22233089
Autor:
Björn Windshügel, Ferdinand Molnár, Tapio Nevalainen, Jayendra Z. Patel, Paavo Honkakoski, Johanna Jyrkkärinne, Tuomo Laitinen, Jenni Küblbeck, Tiina Kuningas, Antti Poso, Wolfgang Sippl
Publikováno v:
Molecular pharmaceutics. 8(6)
The human constitutive androstane receptor (CAR, NR1I3) is one of the key regulators of xenobiotic and endobiotic metabolism. The unique properties of human CAR, such as the high constitutive activity and the complexity of signaling, as well as the l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e674dbbbd11972f78a1f92a94e763064
https://pubmed.ncbi.nlm.nih.gov/22044162
https://pubmed.ncbi.nlm.nih.gov/22044162
Autor:
Ferdinand Molnár, Timo Rousu, Paavo Honkakoski, Tobias Abel, Ari Tolonen, Timo Korjamo, Tanja Kortelainen, Johanna Jyrkkärinne, Tuomo Laitinen, Jouko Uusitalo, Jenni Küblbeck
Publikováno v:
Biochemical pharmacology. 82(12)
The so-called human xenosensors, constitutive androstane receptor (hCAR), pregnane X receptor (hPXR) and aryl hydrocarbon receptor (hAhR), participate in drug metabolism and transport as well as in several endogenous processes by regulating the expre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a17bf43c422a58567e3dbe06b176676d
https://pubmed.ncbi.nlm.nih.gov/21924250
https://pubmed.ncbi.nlm.nih.gov/21924250
Autor:
Johanna Jyrkkärinne, Björn Windshügel, Wolfgang Sippl, Markku Ylisirniö, Mikael Peräkylä, Paavo Honkakoski, Janne Mäkinen, Antti Poso
Publikováno v:
The Journal of biological chemistry. 280(7)
The human constitutive androstane receptor (CAR, NR1I3) is an important ligand-activated regulator of oxidative and conjugative enzymes and transport proteins. Because of the lack of a crystal structure of the ligand-binding domain (LBD), wide specie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae6688acee69821b7b0f6ad22519cb69
https://pubmed.ncbi.nlm.nih.gov/15572376
https://pubmed.ncbi.nlm.nih.gov/15572376
Autor:
Paavo Honkakoski, Mika Reinisalo, Johanna Jyrkkärinne, Olavi Pelkonen, Hinfan Chung, Kaisa Niemi, Janne Mäkinen, Pirkko Viitala
mCAR (mouse constitutive androstane receptor; NR1I3) controls the expression of cytochrome P450 as well as other enzymes involved in drug and steroid metabolism. The high basal activity of mCAR can be modulated by inhibitory steroids related to andro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6b6ac4eb38749a87297b34ab8b33766
https://europepmc.org/articles/PMC1223782/
https://europepmc.org/articles/PMC1223782/
