Invasive and noninvasive markers of human skeletal muscle mitochondrial function

Autor: Rodrigo Mancilla, Diego Pava‐Mejia, Nynke vanPolanen, Vera deWit, Maaike Bergman, Lotte Grevendonk, Johanna Jorgensen, Esther Kornips, Joris Hoeks, Matthijs K. C. Hesselink, Vera B. Schrauwen‐Hinderling

Publikováno v: Physiological Reports, Vol 11, Iss 12, Pp n/a-n/a (2023)

Abstract Mitochondria are organelles that fuel cellular energy requirements by ATP formation via aerobic metabolism. Given the wide variety of methods to assess skeletal muscle mitochondrial capacity, we tested how well different invasive and noninva

Externí odkaz: https://doaj.org/article/e51d1203343b480098a2feb69c51dec1

PCr/ATP ratios and mitochondrial function in the heart. A comparative study in humans

Autor: Patrique Segers, Vera B. Schrauwen-Hinderling, Tineke van de Weijer, M. K. C. Hesselink, Gert Schaart, Kim Brouwers, Johanna Jorgensen, Joachim E. Wildberger, Joris Hoeks, Vera H. W. de Wit-Verheggen, Bart Staels, Lucas Lindeboom, Emmani B.M. Nascimento, David Montaigne, Patrick Schrauwen, Anne Gemmink

Publikováno v: Scientific Reports. 13

Objectives The objective of the study was to validate PCr/ATP ratios as an in vivo marker for cardiac mitochondrial function.Background Cardiac energy status, measured as PCr/ATP ratio with 31P-MRS in vivo, was shown to be a prognostic factor in hear

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf1d3005df6027d231189ad9bb4dc158
https://doi.org/10.1038/s41598-023-35041-7

Dissociation of intramyocellular lipid storage and insulin resistance in trained athletes and type 2 diabetes patients; involvement of perilipin 5?

Autor: Patrick Schrauwen, Johanna Jorgensen, Gert Schaart, Joris Hoeks, Esther Moonen-Kornips, Matthijs K. C. Hesselink, Bram Brouwers, Sabine Daemen, Anne Gemmink, Peter Huntjens

Publikováno v: The Journal of Physiology. 596:857-868

Intramyocellular lipids (IMCL) hamper insulin sensitivity albeit not in endurance-trained athletes (Trained). Compared to type 2 diabetes patients (T2DM), Trained subjects have high levels of Perilipin 5 (PLIN5). Here, we tested if the fraction of PL

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c46875c63e5cc3e273dbad7c1c571c34
https://doi.org/10.1113/jp275182

Effects of Bezafibrate Treatment in a Patient and a Carrier With Mutations in the PNPLA2 Gene, Causing Neutral Lipid Storage Disease With Myopathy

Autor: L. Bilet, Gert Schaart, Sabina Paglialunga, Vera B. Schrauwen-Hinderling, Madeleen Bosma, Rudolf Zechner, Hans P. Sauerwein, Bas Havekes, Joris Hoeks, Lauren M. Sparks, Matthijs K. C. Hesselink, Joep L.R.M. Smeets, Patrick Schrauwen, Tineke van de Weijer, Mirian C.H. Janssen, Johanna Jorgensen, Joachim E. Wildberger

Publikováno v: Circulation Research, 112, e51-4
Circulation Research, 112(5), e51-54. LIPPINCOTT WILLIAMS & WILKINS
Circulation Research, 112, 5, pp. e51-4

Neutral lipid storage disease with myopathy (NLSDM) is a rare but severe genetic disorder characterized by excessive lipid accumulation in tissues including skin, bone marrow, heart, liver, and muscles. Clinically, NLSDM patients present with severe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8750645ae1655aade0821026e2559b9f
https://doi.org/10.1161/circresaha.113.300944

Overexpression of PLIN5 in skeletal muscle promotes oxidative gene expression and intramyocellular lipid content without compromising insulin sensitivity

Autor: Madeleen Bosma, Guido J. E. J. Hooiveld, Sander Kersten, Patrick Schrauwen, Johanna Jorgensen, Lauren M. Sparks, Matthijs K. C. Hesselink, Sander M. Houten

Publikováno v: BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 1831(4), 844-852. Elsevier
Biochimica et Biophysica Acta. Molecular and Cell Biology of Lipids 1831 (2013) 4
Biochimica et Biophysica Acta. Molecular and Cell Biology of Lipids, 1831(4), 844-852
Biochimica et Biophysica Acta-Molecular and Cell Biology of Lipids, 1831(4), 844-852. Elsevier

Aims/hypothesis: While lipid deposition in the skeletal muscle is considered to be involved in obesity-associated insulin resistance, neutral intramyocellular lipid (IMCL) accumulation per se does not necessarily induce insulin resistance. We previou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1257279a2dc2cd41f17187929e198c54
https://pubmed.ncbi.nlm.nih.gov/23353597