Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Johanna Haglund"'
Autor:
Göran Eklund, Magnus M. Halldin, Åsa Brunnström, Antti Kautiainen, Anna Sandholm, Johanna Haglund, Suzanne L. Iverson
Publikováno v:
Chemical Research in Toxicology. 27:601-610
The recent stream of regulatory guidelines on the Safety Testing of Drug Metabolites by the FDA in 2008 and the ICH in 2009 and 2012 has cast light on the importance of qualifying metabolite exposure as part of the safety evaluation of new drugs and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ab2747806db685eee0b2050e012ad45
https://doi.org/10.1021/tx400449z
https://doi.org/10.1021/tx400449z
Enantioselective Formation of Methyl Sulfone Metabolites of 2,2‘,3,3‘,4,6‘-Hexachlorobiphenyl in Rat
Publikováno v:
Environmental Science & Technology. 40:7649-7655
Several nonsymmetric polychlorinated biphenyl (PCB) congeners form atropisomers due to steric hindrance of free rotation around the phenyl-phenyl bond. It is evident from the literature that both chiral PCB congeners and their atropisomeric methylsul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d712debd37340195db78fd2b39fa202
https://doi.org/10.1021/es061584t
https://doi.org/10.1021/es061584t
Publikováno v:
Toxicological & Environmental Chemistry. 85:81-94
The strongly nucleophilic cob(I)alamin, i.e. Vitamin B12 with Co(III) reduced to Co(I), is introduced as a trapping agent in the determination of concentrations of electrophilic reagents. This compound was applied, in comparison with the previously u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a5a78f34d439ba185d416765ce0c696b
https://doi.org/10.1080/02772240410001665508
https://doi.org/10.1080/02772240410001665508
Publikováno v:
Rapid Communications in Mass Spectrometry. 15:2438-2445
In recent years, the awareness of environmentally hazardous compounds with polar and ionizable properties has intensified. Pharmaceuticals, the pesticide tebuconazole as well as the artificial sweetener sucralose are examples of such new, emerging, c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a2ca89e8aceedba4783c53ddd383d1f
https://doi.org/10.1002/rcm.527
https://doi.org/10.1002/rcm.527
Publikováno v:
Chemico-Biological Interactions. 108:119-133
Reactive compounds form adducts at several sites in DNA. One of these sites, the phosphate groups, forms phosphotriesters (PTE) which are both chemically stable and little repaired. A measurement of PTE in DNA could therefore be advantageous for the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f9e50db36a5bc56ca52eda583964297
https://doi.org/10.1016/s0009-2797(97)00102-6
https://doi.org/10.1016/s0009-2797(97)00102-6
Autor:
Tomas Alsberg, Johan Eriksson, Margareta Törnqvist, Johanna Haglund, Emelie Westberg, Ulla Hedebrant, Albrecht Seidel
Publikováno v:
Analytical and bioanalytical chemistry. 406(5)
Stable adducts to serum albumin (SA) from electrophilic and genotoxic compounds/metabolites can be used as biomarkers for quantification of the corresponding in vivo dose. In the present study, conditions for specific analysis of stable adducts to SA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0917e5a366a0bd2d67892451ba98b8b
https://pubmed.ncbi.nlm.nih.gov/24390408
https://pubmed.ncbi.nlm.nih.gov/24390408
Publikováno v:
Chemical research in toxicology. 22(9)
The reduced state of vitamin B(12), cob(I)alamin, acts as a supernucleophile that reacts ca. 10(5) times faster than standard nucleophiles, for example, thiols. Methods have been developed for trapping electrophilically reactive compounds by exploiti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0a136671e99919d6e04b4af596b36a3
https://pubmed.ncbi.nlm.nih.gov/19764821
https://pubmed.ncbi.nlm.nih.gov/19764821
Publikováno v:
Journal of chromatography: A: bibliography section
The reduced form of vitamin B12 [cob(I)alamin] is known to be a supernucleophile, with the ability to react 105 times faster than standard nucleophiles. Procedures have been developed where cob(I)alamin is used as an analytical tool for the trapping
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ff3be930ee659517c27f55ed16bd7e4
https://hdl.handle.net/10067/600220151162165141
https://hdl.handle.net/10067/600220151162165141
Autor:
Bernard T. Golding, Johanna Haglund, Dag Jenssen, V. Silvari, Lars Ehrenberg, Margareta Törnqvist
Publikováno v:
Mutation research. 580(1-2)
Values for reaction-kinetic parameters of electrophiles can be used to predict mutagenic potency. One approach employs the Swain-Scott relationship for comparative kinetic studies of electrophilic agents reacting with nucleophiles. In this way glycid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32ccbfbace8960287aa14c6bb2ff81dd
https://pubmed.ncbi.nlm.nih.gov/15668111
https://pubmed.ncbi.nlm.nih.gov/15668111
Autor:
Johanna Minten, Per Rydberg, Margareta Törnqvist, Charlotta Fred, Thomas Alsberg, Johanna Haglund
Publikováno v:
Journal of separation science. 27(7-8)
Analytical methods facilitating studies of electrophilically reactive and genotoxic compounds in vitro and in vivo are needed. The strong nucleophile, cob(I)alamin, formed by reduction of Vitamin B12 [cob(III)alamin], may be used for trapping and ana
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2469d36361459982f77bb379ee149658
https://pubmed.ncbi.nlm.nih.gov/15335048
https://pubmed.ncbi.nlm.nih.gov/15335048