Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Johanna H. M. Ehrler"'
Autor:
Laura Isigkeit, Tim Hörmann, Espen Schallmayer, Katharina Scholz, Felix F. Lillich, Johanna H. M. Ehrler, Benedikt Hufnagel, Jasmin Büchner, Julian A. Marschner, Jörg Pabel, Ewgenij Proschak, Daniel Merk
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Generative deep learning models enable data-driven de novo design of molecules with tailored features. Chemical language models (CLM) trained on string representations of molecules such as SMILES have been successfully employed to design new
Externí odkaz:
https://doaj.org/article/18a8f717a7c64c0f81f6b3644f448ee3
Autor:
Steffen Brunst, Julia Schönfeld, Peter Breunig, Luisa D. Burgers, Murphy DeMeglio, Johanna H. M. Ehrler, Felix F. Lillich, Lilia Weizel, Jasmin K. Hefendehl, Robert Fürst, Ewgenij Proschak, Kerstin Hiesinger
Publikováno v:
ACS Medicinal Chemistry Letters. 13:1062-1067
Soluble epoxide hydrolase (sEH) is a promising target for a number of inflammation-related diseases. In addition, inhibition of sEH has been shown to reduce neuroinflammation, which plays a critical role in the development of central nervous system (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5984b553261d1d005e3c6b5772b1cc52
https://doi.org/10.1021/acsmedchemlett.2c00073
https://doi.org/10.1021/acsmedchemlett.2c00073