Impaired lymph node stromal cell function during the earliest phases of rheumatoid arthritis

Autor: Janine S. Hähnlein, Reza Nadafi, Tineke de Jong, Tamara H. Ramwadhdoebe, Johanna F. Semmelink, Karen I. Maijer, IJsbrand A. Zijlstra, Mario Maas, Danielle M. Gerlag, Teunis B. H. Geijtenbeek, Paul P. Tak, Reina E. Mebius, Lisa G. M. van Baarsen

Publikováno v: Arthritis Research & Therapy, Vol 20, Iss 1, Pp 1-12 (2018)

Abstract Background Systemic autoimmunity can be present years before clinical onset of rheumatoid arthritis (RA). Adaptive immunity is initiated in lymphoid tissue where lymph node stromal cells (LNSCs) regulate immune responses through their intima

Externí odkaz: https://doaj.org/article/791ad70409a34ac39aabe61b93ef46c5

Lower Metabolic Potential and Impaired Metabolic Flexibility in Human Lymph Node Stromal Cells from Patients with Rheumatoid Arthritis

Autor: Tineke A. de Jong, Johanna F. Semmelink, Simone W. Denis, Janne W. Bolt, Mario Maas, Marleen G. H. van de Sande, Riekelt H. L. Houtkooper, Lisa G. M. van Baarsen

Publikováno v: de Jong, T A, Semmelink, J F, Denis, S W, Bolt, J W, Maas, M, van de Sande, M G H, Houtkooper, R H L & van Baarsen, L G M 2023, ' Lower Metabolic Potential and Impaired Metabolic Flexibility in Human Lymph Node Stromal Cells from Patients with Rheumatoid Arthritis ', Cells, vol. 12, no. 1, 1 . https://doi.org/10.3390/cells12010001
Cells; Volume 12; Issue 1; Pages: 1
Cells, 12(1):1. MDPI Multidisciplinary Digital Publishing Institute

Cellular metabolism is important for determining cell function and shaping immune responses. Studies have shown a crucial role for stromal cells in steering proper immune responses in the lymph node microenvironment. These lymph node stromal cells (L

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8197913d7b68301825c719360e54e19a
https://research.vumc.nl/en/publications/cb7bbf83-6520-4317-80a1-f6fb21f12ee2