Výsledky vyhledávání - "Johanna E. Plehn"

RNA marker modifications reveal the necessity for rigorous preparation protocols to avoid artifacts in epitranscriptomic analysis

Autor: Johanna E Plehn, Mark Helm, Larissa Bessler, Kristina Friedland, Marko Jörg, Cansu Cirzi, Francesca Tuorto, Florian Richter, Jasmin Hertler

Publikováno v: Nucleic Acids Research. 50:4201-4215

The accurate definition of an epitranscriptome is endangered by artefacts resulting from RNA degradation after cell death, a ubiquitous yet little investigated process. By tracing RNA marker modifications through tissue preparation protocols, we iden

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a5cfff8705835876b424b1bd9248c70
https://doi.org/10.1093/nar/gkab1150

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Mitochondrial Dysfunction as a Causative Factor in Alzheimer's Disease-Spectrum Disorders: Lymphocytes as a Window to the Brain

Autor: Marko Jörg, Johanna E. Plehn, Kristina Friedland, Walter E. Müller

Publikováno v: Current Alzheimer research. 18(10)

Alzheimer’s disease (AD) is the most common progressive neurodegenerative disease. Today, AD affects millions of people worldwide and the number of AD cases will further increase with longer life expectancy. The AD brain is marked by severe neurode

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d07d5a5be498271b9445c260d7bab8e
https://pubmed.ncbi.nlm.nih.gov/34879802

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Manganese Ions Individually Alter the Reverse Transcription Signature of Modified Ribonucleosides

Autor: Yuri Motorin, Kristina Friedland, Johanna E Plehn, Mark Helm, Stephan Werner, Virginie Marchand, Marco Kristen

Publikováno v: Genes
Genes, MDPI, 2020, 11 (8), pp.950. ⟨10.3390/genes11080950⟩
Genes, 2020, 11 (8), pp.950. ⟨10.3390/genes11080950⟩
Volume 11
Issue 8
Genes, Vol 11, Iss 950, p 950 (2020)

Reverse transcription of RNA templates containing modified ribonucleosides transfers modification-related information as misincorporations, arrest or nucleotide skipping events to the newly synthesized cDNA strand. The frequency and proportion of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dd73726a9d3f7530dc15ffcc3f486b9
https://hal.univ-lorraine.fr/hal-02929785

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