Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Johanna E. Mayrhofer"'
Mutation-oriented profiling of autoinhibitory kinase conformations predicts RAF inhibitor efficacies
Autor:
Eduard Stefan, Omar Torres-Quesada, Egon Ogris, Johanna E. Mayrhofer, Philipp Tschaikner, Andreas Feichtner, Florian Enzler, Andrea Raffeiner, Jakob Troppmair, Markus Hartl, Rainer Schneider, Roland G. Huber, Ruth Röck, Jakob Fleischmann
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance The pharmaceutical targeting of mutated BRAF has shown promising clinical outcomes in patients with melanoma. However, more than 300 reported BRAF patient mutations and the occurrence of a kinase-drug resistance mechanism hamper patient-
Autor:
Omar Torres-Quesada, Jakob Troppmair, Ruth Röck, Eduard Stefan, Johanna E. Mayrhofer, Florian Enzler
Publikováno v:
Molecular Cancer Research. 18:B45-B45
Live-cell recordings of protein conformations and interactions yield novel mechanistic insights into physiologic and pathologic protein functions. We have developed an adaptable and genetically encoded bioluminescence-based biosensor platform to prec
Autor:
Ruth, Röck, Johanna E, Mayrhofer, Omar, Torres-Quesada, Florian, Enzler, Andrea, Raffeiner, Philipp, Raffeiner, Andreas, Feichtner, Roland G, Huber, Shohei, Koide, Susan S, Taylor, Jakob, Troppmair, Eduard, Stefan
Publikováno v:
Science Advances
Patient mutation–specific BRAF inhibitors alter full-length kinase conformations and promote interactions with GTP-loaded RAS.
Oncogenic BRAF mutations initiate tumor formation by unleashing the autoinhibited kinase conformation and promoting
Oncogenic BRAF mutations initiate tumor formation by unleashing the autoinhibited kinase conformation and promoting
Publikováno v:
Cellular signalling. 37
Cellular signal transmission requires the dynamic formation of spatiotemporally controlled molecular interactions. At the cell surface information is received by receptor complexes and relayed through intracellular signaling platforms which organize
Autor:
Verena Bachmann, Eduard Stefan, Federico Apelt, Philipp Raffeiner, Tsan-Wen Lu, Pierre Thibault, George S. Baillie, Mathieu Courcelles, Susan S. Taylor, Johanna E. Mayrhofer, Ronit Ilouz, Ulrich Stelzl, Philipp Tschaikner, Ruth Röck, Pia Aanstad
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 113(28)
Scaffolding proteins organize the information flow from activated G protein-coupled receptors (GPCRs) to intracellular effector cascades both spatially and temporally. By this means, signaling scaffolds, such as A-kinase anchoring proteins (AKAPs), c
Publikováno v:
Frontiers in Pharmacology, Vol 6 (2015)
Figure 5. Impact of RIa mutations and cAMP elevation on PKA type I complexes. . . . (B) Following indicated modifications of RIa-F[1] sequences, combinations of wild type and mutant Rluc PCA tagged PKA subunits have been subjected to Rluc PCA measure
Autor:
Ruth Röck, Verena Bachmann, Hyo-eun C Bhang, Mohan Malleshaiah, Philipp Raffeiner, Johanna E Mayrhofer, Philipp M Tschaikner, Klaus Bister, Pia Aanstad, Martin G Pomper, Stephen W Michnick, Eduard Stefan
Publikováno v:
Scientific Reports
Membrane receptor-sensed input signals affect and modulate intracellular protein-protein interactions (PPIs). Consequent changes occur to the compositions of protein complexes, protein localization and intermolecular binding affinities. Alterations o