Exploring the predictive potential of programmed death ligand 1 expression in healthy organs and lymph nodes as measured by 18F-BMS-986192 PET: pooled analysis of data from four solid tumor types

Autor: Tanja D de Gruijl, Rieneke van de Ven, Geke A P Hospers, Marc C Huisman, Gerben J C Zwezerijnen, C Willemien Menke-van der Houven van Oordt, Iris H C Miedema, Johanna E. E. Pouw, Anne Kwakman, Florentine E F Timmer, Adrianus J de Langen

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 12, Iss 6 (2024)

Introduction Immune checkpoint inhibitors (ICIs) can elicit anticancer immune responses, but predictive biomarkers are needed. We measured programmed death ligand 1 (PD-L1) expression in organs and lymph nodes using 18F-BMS-986192 positron emission t

Externí odkaz: https://doaj.org/article/25fc274b5a5a47a2b15beea98d6e7ced

First exploration of the on-treatment changes in tumor and organ uptake of a radiolabeled anti PD-L1 antibody during chemoradiotherapy in patients with non-small cell lung cancer using whole body PET

Autor: Tanja D de Gruijl, Teodora Radonic, Marc C Huisman, Idris Bahce, Johanna E E Pouw, Sayed M S Hashemi, Jessica E Wijngaarden, Maarten Slebe, Daniela E Oprea-Lager, Gerben J C Zwezerijnen, Danielle Vugts, Ezgi B Ulas, Suresh Senan, C Willemien Menke-van der Houven van Oordt

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 12, Iss 2 (2024)

Background In patients with locally advanced unresectable non-small cell lung cancer (NSCLC), durvalumab, an anti-programmed cell death ligand-1 (PD-L1) antibody, has shown improved overall survival when used as consolidation therapy following concur

Externí odkaz: https://doaj.org/article/4b3a18abdb6f4a34986c4c57af3d9db7

Irreversible electroporation and nivolumab combined with intratumoral administration of a toll‐like receptor ligand, as a means of in vivo vaccination for metastatic pancreatic ductal adenocarcinoma (Panfire‐iii). a phase‐i study protocol

Autor: Bart Geboers, Florentine E. F. Timmer, Alette H. Ruarus, Johanna E. E. Pouw, Evelien A. C. Schouten, Joyce Bakker, Robbert S. Puijk, Sanne Nieuwenhuizen, Madelon Dijkstra, M. Petrousjka van den Tol, Jan J. J. de Vries, Daniela E. Oprea-Lager, C. Willemien Menke-van der Houven van Oordt, Hans J. van der Vliet, Johanna W. Wilmink, Hester J. Scheffer, Tanja D. de Gruijl, Martijn R. Meijerink, on behalf of the Dutch Pancreatic Cancer Group

Publikováno v: on behalf of the Dutch Pancreatic Cancer Group 2021, ' Irreversible electroporation and nivolumab combined with intratumoral administration of a toll-like receptor ligand, as a means of in vivo vaccination for metastatic pancreatic ductal adenocarcinoma (Panfire-iii). a phase-i study protocol ', Cancers, vol. 13, no. 15, 3902 . https://doi.org/10.3390/cancers13153902
Cancers, 13(15):3902. Multidisciplinary Digital Publishing Institute (MDPI)
Cancers, Vol 13, Iss 3902, p 3902 (2021)
Cancers

Simple Summary Metastatic pancreatic ductal adenocarcinoma has a dismal prognosis, and to date no curative treatment options exist. The image guided tumor ablation technique irreversible electroporation (IRE) employs high-voltage electrical pulses th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::283047df039ee4be61d74cb94fc30e5c
https://research.vumc.nl/en/publications/9ca3c4cd-2906-4e7b-9152-4a15ebb62f56

How to obtain the image-derived blood concentration from ⁸⁹Zr-immuno-PET scans.

Autor: Wijngaarden, Jessica E., Ahbari, Amina, Pouw, Johanna E. E., Greuter, Henri N. J. M., Bahce, Idris, Zwezerijnen, Gerben J. C., Vugts, Daniëlle J., van Dongen, Guus A. M. S., Boellaard, Ronald, Menke-van der Houven van Oordt, C. Willemien, Huisman, Marc C.

Publikováno v: EJNMMI Physics; 2/7/2024, Vol. 11 Issue 1, p1-9, 9p

Researchers from Cancer Centre Amsterdam Discuss Research in Oral Cancer (Exploring the predictive potential of programmed death ligand 1 expression in healthy organs and lymph nodes as measured by 18F-BMS986-192 PET: pooled analysis of data...).

Publikováno v: Medical Imaging Week; 7/5/2024, p1259-1259, 1p