Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Johanna De-Castro Arce"'
Autor:
Jillian de Wilde, Johanna De-Castro Arce, Peter J. F. Snijders, Chris J. L. M. Meijer, Frank Rösl, Renske D. M. Steenbergen
Publikováno v:
Cellular Oncology, Vol 30, Iss 1, Pp 77-87 (2008)
Background: Previous studies demonstrated a functional involvement of the AP-1 transcription factor in HPV-induced cervical carcinogenesis. Here, we aimed to obtain further insight in expression alterations of AP-1 family members during HPV-mediated
Externí odkaz:
https://doaj.org/article/7f4e8ab39bce451db93329d0ec519c23
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e32590 (2012)
The serine/threonine kinase LKB1 is a tumour suppressor that regulates multiple biological pathways, including cell cycle control, cell polarity and energy metabolism by direct phosphorylation of 14 different AMP-activated protein kinase (AMPK) famil
Externí odkaz:
https://doaj.org/article/cd1539e7adcf490984bb93999ac52ff1
Publikováno v:
Human Molecular Genetics. 21:1693-1705
In the present study, we used the human papillomavirus type 16 (HPV16)-positive cervical carcinoma cell line CaSki as a paradigmatic model to understand epigenetic silencing of viral multi-copy genomes. We show that most of the hypermethylated HPV16
Autor:
Sybille Mazurek, Andrea Patzelt, Johanna De-Castro Arce, Julia Nafz, Frank Rösl, Verena Fleig
Publikováno v:
Biochemical Journal. 403:501-510
Carcinogenesis is a dynamic and stepwise process, which is accompanied by a variety of somatic and epigenetic alterations in response to a changing microenvironment. Hypoxic conditions will select for cells that have adjusted their metabolic profile
Autor:
Jan van Riggelen, Frank Rösl, Elisabeth Schwarz, Ubaldo Soto, Harald zur Hausen, Johanna De-Castro Arce
Publikováno v:
Journal of Biological Chemistry. 279:45408-45416
Expression of the nuclear retinoic acid receptor beta2 (RARbeta2) gene is often disturbed in cervical carcinoma cells. One important mechanism by which RARbeta2 can exert growth inhibitory function is based on its ability to repress the AP-1 transcri
Publikováno v:
PLoS ONE
PLoS ONE, Vol 7, Iss 3, p e32590 (2012)
PLoS ONE, Vol 7, Iss 3, p e32590 (2012)
The serine/threonine kinase LKB1 is a tumour suppressor that regulates multiple biological pathways, including cell cycle control, cell polarity and energy metabolism by direct phosphorylation of 14 different AMP-activated protein kinase (AMPK) famil
Autor:
Thomas R. Broker, Peter J.F. Snijders, N. Sanjib Banerjee, Renske D.M. Steenbergen, Louise T. Chow, Chris J.L.M. Meijer, Frank Rösl, Florianne E. Henken, Johanna De-Castro Arce
Publikováno v:
Molecular Cancer
Molecular Cancer, 10:71. BioMed Central
Henken, F E, Banerjee, NS, Snijders, P J F, Meijer, C J L M, De-Castro Arce, J, Rosl, F, Broker, TR, Chow, L T & Steenbergen, R D M 2011, ' PIK3CA-mediated PI3-kinase signalling is essential for HPV-induced transformation in vitro ', Molecular Cancer, vol. 10, 71 . https://doi.org/10.1186/1476-4598-10-71
Molecular Cancer, Vol 10, Iss 1, p 71 (2011)
Molecular Cancer, 10:71. BioMed Central
Henken, F E, Banerjee, NS, Snijders, P J F, Meijer, C J L M, De-Castro Arce, J, Rosl, F, Broker, TR, Chow, L T & Steenbergen, R D M 2011, ' PIK3CA-mediated PI3-kinase signalling is essential for HPV-induced transformation in vitro ', Molecular Cancer, vol. 10, 71 . https://doi.org/10.1186/1476-4598-10-71
Molecular Cancer, Vol 10, Iss 1, p 71 (2011)
Background High-risk human papillomavirus (hrHPV) infections are causally related to cervical cancer development. The additional (epi)genetic alterations driving malignant transformation of hrHPV-infected cells however, are not yet fully elucidated.
Autor:
Johanna De-Castro Arce, Renske D.M. Steenbergen, Simone Rosenberger, Frank Rösl, Lutz Langbein
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 107(15), 7006-7011. National Academy of Sciences
Rosenberger, S, Arce, J D C, Langbein, L, Steenbergen, R D M & Rosl, F 2010, ' Alternative splicing of human papillomavirus type-16 E6/E6*early mRNA is coupled to EGF signaling via Erk1/2 activation ', Proceedings of the National Academy of Sciences of the United States of America, vol. 107, no. 15, pp. 7006-7011 . https://doi.org/10.1073/pnas.1002620107
Rosenberger, S, Arce, J D C, Langbein, L, Steenbergen, R D M & Rosl, F 2010, ' Alternative splicing of human papillomavirus type-16 E6/E6*early mRNA is coupled to EGF signaling via Erk1/2 activation ', Proceedings of the National Academy of Sciences of the United States of America, vol. 107, no. 15, pp. 7006-7011 . https://doi.org/10.1073/pnas.1002620107
Certain types of human papillomaviruses (HPVs) are etiologically linked to cervical cancer. Their transforming capacity is encoded by a polycistronic premRNA, where alternative splicing leads to the translation of functional distinct proteins such as
Publikováno v:
The Journal of biological chemistry. 282(39)
Retinoic acid receptor beta2 (RAR beta2) is often down-regulated during the multistep process to cervical cancer. In that way, its inhibitory function on the transcription factor AP-1, indispensable to maintain human papillomavirus (HPV) gene express
Autor:
Jan van Riggelen, Johanna De-Castro Arce, Ubaldo Soto, Bohdan Wasylyk, Frank Rösl, Harald zur Hausen, Gilles Buchwalter
Publikováno v:
Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2005, 280 (5), pp.3286-94. ⟨10.1074/jbc.M409915200⟩
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2005, 280 (5), pp.3286-94. ⟨10.1074/jbc.M409915200⟩
International audience; We have investigated the expression of c-fos in cervical carcinoma cells and in somatic cell hybrids derived therefrom. In malignant cells, c-fos was constitutively expressed even after serum starvation. Dissection of the c-fo