Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Johanna D. Stoeckler"'
Publikováno v:
Anti-Cancer Drugs. 13:965-975
An i.v. formulation of rubitecan (9-nitrocamptothecin) was evaluated in five human solid tumor xenograft models. Rubitecan in IDD-P, a particulate suspension of the insoluble analog, produced significant tumor growth delay In athymic nude mice bearin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3048a28bfb7f6d900b32fd0f4fb323ef
https://doi.org/10.1097/00001813-200210000-00009
https://doi.org/10.1097/00001813-200210000-00009
Publikováno v:
Biochemistry. 36:11735-11748
X-ray crystallography, molecular modeling, and site-directed mutagenesis were used to delineate the catalytic mechanism of purine nucleoside phosphorylase (PNP). PNP catalyzes the reversible phosphorolysis of purine nucleosides to the corresponding p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15738d97403818940de7c7f4a8a40b25
https://doi.org/10.1021/bi961970v
https://doi.org/10.1021/bi961970v
Purine Nucleoside Phosphorylase. 3. Reversal of Purine Base Specificity by Site-Directed Mutagenesis
Autor:
Robert E. Parks, Steven E. Ealick, Anne F. Poirot, Kenji Takabayashi, Mark D. Erion, Johanna D. Stoeckler, Rose Marie Smith
Publikováno v:
Biochemistry. 36:11749-11756
Human purine nucleoside phosphorylase (PNP) is highly specific for 6-oxopurine nucleosides with a catalytic efficiency (kcat/KM) for inosine 350000-fold greater than for adenosine. Crystallographic studies identified Asn243 and Glu201 as the residues
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f6b7df5b3c0d273fb683c3cd1e0ca4d
https://doi.org/10.1021/bi961971n
https://doi.org/10.1021/bi961971n
Publikováno v:
Bioorganic & Medicinal Chemistry. 4:1725-1731
The synthesis of S4-substituted nucleosides possessing the imidazo- and v-triazolo[4,5-d]pyridazine ring systems was undertaken and the compounds prepared were evaluated as inhibitors of nucleoside transport into human erythrocytes. 1-(2,3,5-Tri-O-ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76410bdece04e0e1664687d3ce318f52
https://doi.org/10.1016/0968-0896(96)00188-5
https://doi.org/10.1016/0968-0896(96)00188-5
Autor:
Johanna D. Stoeckler, Mallela S. P. Sarma, Palle V. P. Pragnacharyulu, Elie Abushanab, Shih-Ying Li, Chandra Vargeese
Publikováno v:
Journal of Medicinal Chemistry. 37:3844-3849
The synthesis and biological evaluation of three chain-hydroxylated (+)-erythro-9-(2S-hydroxy-3R-nonyl)adenine [(+)-EHNA] derivatives are reported. Hydroxy groups at positions 9', 8', and 8',9' (12, 25, and 16) were introduced by either epoxidation o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b82585faf46a126d13313b34d26d4da
https://doi.org/10.1021/jm00048a020
https://doi.org/10.1021/jm00048a020
Autor:
Johanna D. Stoeckler, Jindrich Symersky, Steven E. Ealick, Anne F. Poirot, Richard L. Walter, Mark D. Erionf
Publikováno v:
Nucleosides and Nucleotides. 13:689-706
The three-dimensional structures of the complexes between human erythrocytic purine nucleoside phosphorylase (PNP) and both 1-β-D-ribofuranosyl-1,2,4-triazole-3-carboxamide (ribavirin) and 1-β-D-ribofuranosyl-1,2,4-triazole-3-carboxamidine (TCNR) h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d8b7aad426347f0e650087f46c183d94
https://doi.org/10.1080/15257779408013273
https://doi.org/10.1080/15257779408013273
Publikováno v:
Nucleosides and Nucleotides. 13:389-403
Adenosine derivatives lacking a 5′-hydroxyl group seldom act as alternative substrates of adenosine deaminases from calf intestine and other mammalian sources. A deaminase from Aspergillus oryzae deaminated adenosine 5′-thioether derivatives clea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::809e62693d0bdb14a0fb7d1ad662281f
https://doi.org/10.1080/15257779408013249
https://doi.org/10.1080/15257779408013249
Autor:
Kakarla Ramesh, Raymond P. Panzica, Jacqueline C. Bussolari, Shih Fong Chen, Johanna D. Stoeckler
Publikováno v:
ChemInform. 25
The chemical synthesis of certain N4-substituted imidazo[4,5-d]pyridazine and v-triazolo[4,5-d]-pyridazine nucleosides is described. In both series, the 4-chloro analogues, i.e., 4-chloro-1-(2,3,5-tri-O-acetyl-beta-D-ribofuranosyl)imidazo[4,5-d]pyr i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cdc00e6db29cc39544595cad760432dc
https://doi.org/10.1002/chin.199425220
https://doi.org/10.1002/chin.199425220
Publikováno v:
ChemInform. 25
The synthesis of the title compound (15) and its 1'-fluoro (12) and 1'-hydroxy (12) derivatives is described. Key intermediate 4-chloro- 1-[1,2-dihydroxy-1,2-O-(ethoxymethylene)-3-nonyl]imidazo[4,5-c]pyridine (10) was obtained by two routes through c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81a7f05830d8baaa7d932dbe37180146
https://doi.org/10.1002/chin.199420280
https://doi.org/10.1002/chin.199420280
Autor:
Johanna D. Stoeckler, Geraldine C. B. Harriman, Rose Marie Midgett, Anne F. Poirot, Elie Abushanab
Publikováno v:
Journal of Medicinal Chemistry. 35:4180-4184
The synthesis of various chiral derivatives of (+)-erythro-9-(2-hydroxy-3-nonyl)adenine, (+)-EHNA, from (2S,3R)-3-amino-1,2-O-isopropylidene-1,2-nonanediol by condensation with 5-amino-4,6-dichloropyrimidine is described. The compounds synthesized we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0d8a1b0b110bf18cd09f365ea43612a
https://doi.org/10.1021/jm00100a025
https://doi.org/10.1021/jm00100a025