Contribution of specific residues of the β-solenoid fold to HET-s prion function, amyloid structure and stability.

Autor: Asen Daskalov, Matthias Gantner, Marielle Aulikki Wälti, Thierry Schmidlin, Celestine N Chi, Christian Wasmer, Anne Schütz, Johanna Ceschin, Corinne Clavé, Sandra Cescau, Beat Meier, Roland Riek, Sven J Saupe

Publikováno v: PLoS Pathogens, Vol 10, Iss 6, p e1004158 (2014)

The [Het-s] prion of the fungus Podospora anserina represents a good model system for studying the structure-function relationship in amyloid proteins because a high resolution solid-state NMR structure of the amyloid prion form of the HET-s prion fo

Externí odkaz: https://doaj.org/article/809e9ec61a7d4cdf9fff4e06d3ad7584

Dual control of NAD + synthesis by purine metabolites in yeast

Autor: Johanna Ceschin, Benoît Pinson, Christelle Saint-Marc, Bertrand Daignan-Fornier

Publikováno v: eLife
eLife, eLife Sciences Publication, 2019, 8, ⟨10.7554/eLife.43808⟩
eLife, Vol 8 (2019)

International audience; Metabolism is a highly integrated process resulting in energy and biomass production. While individual metabolic routes are well characterized, the mechanisms ensuring crosstalk between pathways are poorly described, although

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b33e159749b37f92ab7be69d456a87d
https://hal.archives-ouvertes.fr/hal-02346546/document

Metabolomics and proteomics identify the toxic form and the associated cellular binding targets of the anti-proliferative drug AICAR

Autor: Delphine C, Douillet, Benoît, Pinson, Johanna, Ceschin, Hans C, Hürlimann, Christelle, Saint-Marc, Damien, Laporte, Stéphane, Claverol, Manfred, Konrad, Marc, Bonneu, Bertrand, Daignan-Fornier

Publikováno v: The Journal of biological chemistry. 294(3)

5-Aminoimidazole-4-carboxamide 1-β-d-ribofuranoside (AICAR, or acadesine) is a precursor of the monophosphate derivative 5-amino-4-imidazole carboxamide ribonucleoside 5′-phosphate (ZMP), an intermediate in de novo purine biosynthesis. AICAR prove

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ace5c414032fc143f3f909e3a9bbe8f5
https://pubmed.ncbi.nlm.nih.gov/30478173

An array of nuclear microtubules reorganizes the budding yeast nucleus during quiescence

Autor: Isabelle Sagot, Fabien Courtout, Bénédicte Salin, Damien Laporte, Johanna Ceschin

Publikováno v: The Journal of Cell Biology

A stable monopolar array of nuclear microtubules displaces the nucleolus and kinetochores during quiescence and is required for both quiescence survival and exit.
The microtubule cytoskeleton is a highly dynamic network. In dividing cells, its c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bd8b74c8403e2bff647954104f8fc3a
http://europepmc.org/articles/PMC3840927

Disruption of Nucleotide Homeostasis by the Antiproliferative Drug 5-Aminoimidazole-4-carboxamide-1-β-d-ribofuranoside Monophosphate (AICAR)

Autor: Hans Caspar Hürlimann, Typhaine Violo, Johanna Ceschin, Delphine Albrecht, Christelle Saint-Marc, Bertrand Daignan-Fornier, Michel Moenner, Benoît Pinson

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2015, 290 (39), pp.23947-23959. ⟨10.1074/jbc.M115.656017⟩

5-Aminoimidazole-4-carboxamide-1-β-d-ribofuranoside monophosphate (AICAR) is a natural metabolite with potent anti-proliferative and low energy mimetic properties. At high concentration, AICAR is toxic for yeast and mammalian cells, but the molecula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff6ff1cfc4a2f1727eee63afeb890c44
https://pubmed.ncbi.nlm.nih.gov/26283791