Extracellular vesicles in metabolic dysfunction associated fatty liver disease: mechanisms, diagnostic and therapeutic implications

Autor: Zongmei Wu, Mengmeng Xia, Sandra Serna Salas, Maria Camila Trillos-Almanza, Magnolia Martinez Aguilar, Johanna C. Arroyave-Ospina, Junyu Wang, Marco Arrese, Svenja Sydor, Lars P. Bechmann, Frederike GI van Vilsteren, Hans Blokzijl, Han Moshage

Publikováno v: Exploration of Digestive Diseases, Vol 1, Iss 1, Pp 4-20 (2022)

The prevalence of metabolic dysfunction-associated fatty liver disease (MAFLD) is increasing rapidly worldwide due to the obesity epidemic. Advanced stages of the MAFLD, such as non-alcoholic steatohepatitis (NASH) with advanced fibrosis or cirrhosis

Externí odkaz: https://doaj.org/article/ea74b7ba35244121ac69087233bb96a4

Modulation of Oxidative Stress-Induced Senescence during Non-Alcoholic Fatty Liver Disease

Autor: Johanna Pedroza-Diaz, Johanna C. Arroyave-Ospina, Sandra Serna Salas, Han Moshage

Publikováno v: Antioxidants, Vol 11, Iss 5, p 975 (2022)

Non-alcoholic fatty liver disease is characterized by disturbed lipid metabolism and increased oxidative stress. These conditions lead to the activation of different cellular response mechanisms, including senescence. Cellular senescence constitutes

Externí odkaz: https://doaj.org/article/b6c376ff4176480f9b73043e1b9e1620

Modulatory Effect of Chlorogenic Acid and Coffee Extracts on Wnt/β-Catenin Pathway in Colorectal Cancer Cells

Autor: Hernán Villota, Gloria A. Santa-González, Diego Uribe, Isabel Cristina Henao, Johanna C. Arroyave-Ospina, Carlos J. Barrera-Causil, Johanna Pedroza-Díaz

Publikováno v: Nutrients; Volume 14; Issue 22; Pages: 4880
Nutrients, 14(22):4880. MDPI AG

The Wnt/β-Catenin pathway alterations present in colorectal cancer (CRC) are of special interest in the development of new therapeutic strategies to impact carcinogenesis and the progression of CRC. In this context, different polyphenols present in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::493ae1b2bff43b9de545154659a41825
https://research.rug.nl/en/publications/f2c06e79-e62a-4474-a07e-3c61c82c1175

Metformin protects against diclofenac-induced toxicity in primary rat hepatocytes by preserving mitochondrial integrity via a pathway involving EPAC

Autor: Tatiana Alieva, Han Moshage, José Rodrigo, Yana Geng, Fabio Alejandro Aguilar Mora, Johanna C. Arroyave Ospina, Manon Buist-Homan, Juan M. Soto, Nshunge Musheshe, Xiaodong Cheng, Martina Schmidt, Frank Lezoualc'h

Publikováno v: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 143:112072. ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
Biomedicine & Pharmacotherapy, Vol 143, Iss, Pp 112072-(2021)
E-Prints Complutense. Archivo Institucional de la UCM
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Background and purpose: It has been shown that the antidiabetic drug metformin protects hepatocytes against toxicity by various stressors. Chronic or excessive consumption of diclofenac (DF) - a pain-relieving drug, leads to drug-induced liver injury

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7185ab4e03487345d9aa34794125fd4f
https://research.rug.nl/en/publications/024bf9d2-cd71-465b-9948-bd4b11544155

Chemopreventive effect of coffee against colorectal cancer and hepatocellular carcinoma

Autor: Johanna C. Arroyave, Fabián Cortés-Mancera, Sarah Röthlisberger, Manuel Moreno-Ceballos

Publikováno v: International Journal of Food Properties, Vol 22, Iss 1, Pp 536-555 (2019)

Cancer is a complex and evolving disease that is the leading cause of death in the twenty-first century, and colorectal and liver cancers specifically are in the top 10 cancer types in terms of incidence and mortality; therefore, there has been a shi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4eefe2760065cb324962b6902c63dc5c
https://doaj.org/article/545d663343c9460ea0a9fced849e1d55