Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Johanna Brodin"'
Autor:
Johanna Brodin, Fabio Zanini, Lina Thebo, Christa Lanz, Göran Bratt, Richard A Neher, Jan Albert
Publikováno v:
eLife, Vol 5 (2016)
HIV-1 infection cannot be cured because the virus persists as integrated proviral DNA in long-lived cells despite years of suppressive antiretroviral therapy (ART). In a previous paper (Zanini et al, 2015) we documented HIV-1 evolution in 10 untreate
Externí odkaz:
https://doaj.org/article/d4d3fe22014e42989b5a8ca6b8bd9e1c
Autor:
Fabio Zanini, Johanna Brodin, Lina Thebo, Christa Lanz, Göran Bratt, Jan Albert, Richard A Neher
Publikováno v:
eLife, Vol 4 (2015)
Many microbial populations rapidly adapt to changing environments with multiple variants competing for survival. To quantify such complex evolutionary dynamics in vivo, time resolved and genome wide data including rare variants are essential. We perf
Externí odkaz:
https://doaj.org/article/15f45297e4a04b2ba6ce3e27e31e83dc
Autor:
Johanna Brodin, Charlotte Hedskog, Alexander Heddini, Emmanuel Benard, Richard A Neher, Mattias Mild, Jan Albert
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0119123 (2015)
Next generation sequencing technologies, like ultra-deep pyrosequencing (UDPS), allows detailed investigation of complex populations, like RNA viruses, but its utility is limited by errors introduced during sample preparation and sequencing. By taggi
Externí odkaz:
https://doaj.org/article/c4f77cd85cf84f59a3c7ad9571923346
Autor:
Johanna Brodin, Mattias Mild, Charlotte Hedskog, Ellen Sherwood, Thomas Leitner, Björn Andersson, Jan Albert
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e70388 (2013)
Ultra-deep pyrosequencing (UDPS) is used to identify rare sequence variants. The sequence depth is influenced by several factors including the error frequency of PCR and UDPS. This study investigated the characteristics and source of errors in raw an
Externí odkaz:
https://doaj.org/article/4561f2c9454f42ecab7a2d083fc6ba89
Publikováno v:
Virus Evolution
Mutation rates and fitness costs of deleterious mutations are difficult to measure in vivo but essential for a quantitative understanding of evolution. Using whole genome deep sequencing data from longitudinal samples during untreated HIV-1 infection
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c91a5d8908f144c33402b07dc0cd5ff3
https://doi.org/10.1093/ve/vex003
https://doi.org/10.1093/ve/vex003
Deep sequencing is a powerful and cost-effective tool to characterize the genetic diversity and evolution of virus populations. While modern sequencing instruments readily cover viral genomes many thousand fold and very rare variants can in principle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43d4c9cac7c5e20d383e03e4abd3a746
https://doi.org/10.1101/077313
https://doi.org/10.1101/077313
Mutation rates and fitness costs of deleterious mutations are difficult to measurein vivobut essential for a quantitative understanding of evolution. Using whole genome deep sequencing data from longitudinal samples during untreated HIV-1 infection,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28da1f44780b1c6da6efd6184a1caeb4
Autor:
Jan L. Nouwen, Manfred Kayser, Susan Walsh, Johanna Brodin, Marieke Pingen, Birgitte B. Simen, Marchina E. van der Ende, Mattias Mild, Sander Dinant, Jan Albert, Martin Schutten, Charles A. Boucher
Publikováno v:
Antiviral Therapy, 17(8), 1621-1625. International Medical Press Ltd
Background HIV-1-infected patients can be superinfected with additional HIV-1 variants. Therapy failure can be the consequence of an infection with a resistant strain. Methods A patient was diagnosed with a recent HIV-1 infection in April 2005 and su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a8361f2aad4676522a633436269dd28
https://doi.org/10.3851/IMP2267
https://doi.org/10.3851/IMP2267