Výsledky vyhledávání - "Johanna Andrae"

Akademický článek

Severe cerebellar malformations in mutant mice demonstrate a role for PDGF-C/PDGFRα signalling in cerebellar development

Autor: Sara Gillnäs, Radiosa Gallini, Liqun He, Christer Betsholtz, Johanna Andrae

Publikováno v: Biology Open, Vol 11, Iss 8 (2022)

Formation of the mouse cerebellum is initiated in the embryo and continues for a few weeks after birth. Double-mutant mice lacking platelet-derived growth factor C (PDGF-C) and that are heterozygous for platelet-derived growth factor receptor alpha (

Externí odkaz: https://doaj.org/article/4836916f3e454fe592b89a0e41763efa

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Akademický článek

Pericytes Stimulate Oligodendrocyte Progenitor Cell Differentiation during CNS Remyelination

Publikováno v: Cell Reports, Vol 20, Iss 8, Pp 1755-1764 (2017)

The role of the neurovascular niche in CNS myelin regeneration is incompletely understood. Here, we show that, upon demyelination, CNS-resident pericytes (PCs) proliferate, and parenchymal non-vessel-associated PC-like cells (PLCs) rapidly develop. D

Externí odkaz: https://doaj.org/article/4a4c8209548f4d78bf8a35c0c107082d

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Akademický článek

A role for PDGF-C/PDGFRα signaling in the formation of the meningeal basement membranes surrounding the cerebral cortex

Autor: Johanna Andrae, Leonor Gouveia, Radiosa Gallini, Liqun He, Linda Fredriksson, Ingrid Nilsson, Bengt R. Johansson, Ulf Eriksson, Christer Betsholtz

Publikováno v: Biology Open, Vol 5, Iss 4, Pp 461-474 (2016)

Platelet-derived growth factor-C (PDGF-C) is one of three known ligands for the tyrosine kinase receptor PDGFRα. Analysis of Pdgfc null mice has demonstrated roles for PDGF-C in palate closure and the formation of cerebral ventricles, but redundancy

Externí odkaz: https://doaj.org/article/95e79d6dd6f84317a21580160c2d3d97

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Akademický článek

Isoform-Specific Modulation of Inflammation Induced by Adenoviral Mediated Delivery of Platelet-Derived Growth Factors in the Adult Mouse Heart.

Autor: Radiosa Gallini, Jenni Huusko, Seppo Ylä-Herttuala, Christer Betsholtz, Johanna Andrae

Publikováno v: PLoS ONE, Vol 11, Iss 8, p e0160930 (2016)

Platelet-derived growth factors (PDGFs) are key regulators of mesenchymal cells in vertebrate development. To what extent PDGFs also exert beneficial homeostatic or reparative roles in adult organs, as opposed to adverse fibrogenic responses in patho

Externí odkaz: https://doaj.org/article/88e300d7a6544478b3e88093e4260381

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Akademický článek

Characterization of platelet-derived growth factor-A expression in mouse tissues using a lacZ knock-in approach.

Autor: Johanna Andrae, Leonor Gouveia, Liqun He, Christer Betsholtz

Publikováno v: PLoS ONE, Vol 9, Iss 8, p e105477 (2014)

Expression of the platelet-derived growth factor A-chain gene (Pdgfa) occurs widely in the developing mouse, where it is mainly localized to various epithelial and neuronal structures. Until now, in situ mRNA hybridization (ISH) has been the only rel

Externí odkaz: https://doaj.org/article/603f877782b940bdabd69b06bb33492d

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Akademický článek

Brain abnormalities and glioma-like lesions in mice overexpressing the long isoform of PDGF-A in astrocytic cells.

Autor: Inga Nazarenko, Anna Hedrén, Hanna Sjödin, Abiel Orrego, Johanna Andrae, Gijs B Afink, Monica Nistér, Mikael S Lindström

Publikováno v: PLoS ONE, Vol 6, Iss 4, p e18303 (2011)

Deregulation of platelet-derived growth factor (PDGF) signaling is a hallmark of malignant glioma. Two alternatively spliced PDGF-A mRNAs have been described, corresponding to a long (L) and a short (S) isoform of PDGF-A. In contrast to PDGF-A(S), th

Externí odkaz: https://doaj.org/article/3b22392f33f847e0be39c527927e7767

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