Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Johanna A. Jorgensen"'
Autor:
Anne Gemmink, Sabine Daemen, Jakob Wefers, Jan Hansen, Dirk van Moorsel, Puji Astuti, Johanna A. Jorgensen, Esther Kornips, Gert Schaart, Joris Hoeks, Patrick Schrauwen, Matthijs K.C. Hesselink
Publikováno v:
Molecular Metabolism, Vol 72, Iss , Pp 101727- (2023)
Objective: Mitochondrial network dynamics may play role in metabolic homeostasis. Whether mitochondrial network dynamics are involved in adaptations to day–night fluctuations in energy supply and demand is unclear. Here we visualized and quantified
Externí odkaz:
https://doaj.org/article/ec9b4e2549404d0f8c96da16498adf41
Autor:
Yvo J.M. op den Kamp, Anne Gemmink, Marlies de Ligt, Bas Dautzenberg, Esther Kornips, Johanna A. Jorgensen, Gert Schaart, Russell Esterline, Diego A. Pava, Joris Hoeks, Vera B. Schrauwen-Hinderling, Sander Kersten, Bas Havekes, Timothy R. Koves, Deborah M. Muoio, Matthijs K.C. Hesselink, Jan Oscarsson, Esther Phielix, Patrick Schrauwen
Publikováno v:
Molecular Metabolism, Vol 66, Iss , Pp 101620- (2022)
Objective: SGLT2 inhibitors increase urinary glucose excretion and have beneficial effects on cardiovascular and renal outcomes; the underlying mechanism may be metabolic adaptations due to urinary glucose loss. Here, we investigated the cellular and
Externí odkaz:
https://doaj.org/article/ce94ee3f45bd45f3ad7d1120c2287583
Autor:
Vera H. W. de Wit-Verheggen, Vera B. Schrauwen-Hinderling, Kim Brouwers, Johanna A. Jörgensen, Gert Schaart, Anne Gemmink, Emmani B. M. Nascimento, Matthijs K. C. Hesselink, Joachim E. Wildberger, Patrique Segers, David Montaigne, Bart Staels, Patrick Schrauwen, Lucas Lindeboom, Joris Hoeks, Tineke van de Weijer
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Cardiac energy status, measured as phosphocreatine (PCr)/adenosine triphosphate (ATP) ratio with 31P-Magnetic Resonance Spectroscopy (31P-MRS) in vivo, is a prognostic factor in heart failure and is lowered in cardiometabolic disease. It has
Externí odkaz:
https://doaj.org/article/37b93e8a37d543e9a681f2a0a9782dad
Autor:
Sten M. M. van Beek, Yvonne M. H. Bruls, Froukje Vanweert, Ciarán E. Fealy, Niels J. Connell, Gert Schaart, Esther Moonen-Kornips, Johanna A. Jörgensen, Frédéric M. Vaz, Ellen T. H. C. Smeets, Peter J. Joris, Anne Gemmink, Riekelt H. Houtkooper, Matthijs K. C. Hesselink, Tore Bengtsson, Bas Havekes, Patrick Schrauwen, Joris Hoeks
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
β2-agonist treatment improves skeletal muscle glucose uptake and whole-body glucose homeostasis in rodents. Here the authors report that two-weeks of treatment with the β2-agonist clenbuterol improves insulin-stimulated glucose disposal in healthy
Externí odkaz:
https://doaj.org/article/c70a9895a6d34e0086372025f6878383
Autor:
Jakob Wefers, Niels J. Connell, Ciarán E. Fealy, Charlotte Andriessen, Vera de Wit, Dirk van Moorsel, Esther Moonen-Kornips, Johanna A. Jörgensen, Matthijs K.C. Hesselink, Bas Havekes, Joris Hoeks, Patrick Schrauwen
Publikováno v:
Molecular Metabolism, Vol 41, Iss , Pp 101050- (2020)
Objective: Skeletal muscle mitochondrial function and energy metabolism displays day-night rhythmicity in healthy, young individuals. Twenty-four-hour rhythmicity of metabolism has been implicated in the etiology of age-related metabolic disorders. W
Externí odkaz:
https://doaj.org/article/16214f05b5e94fd6a1d1cf4c4c2c0474
Autor:
Dennis Dahlmans, Alexandre Houzelle, Pénélope Andreux, Johanna A. Jörgensen, Xu Wang, Leon J. de Windt, Patrick Schrauwen, Johan Auwerx, Joris Hoeks
Publikováno v:
Molecular Metabolism, Vol 6, Iss 11, Pp 1429-1442 (2017)
Objective: Strategies improving skeletal muscle mitochondrial capacity are commonly paralleled by improvements in (metabolic) health. We and others previously identified microRNAs regulating mitochondrial oxidative capacity, but data in skeletal musc
Externí odkaz:
https://doaj.org/article/d32d600aa61b4cec93b38bbde9c340f4
Autor:
Dirk van Moorsel, Jan Hansen, Bas Havekes, Frank A.J.L. Scheer, Johanna A. Jörgensen, Joris Hoeks, Vera B. Schrauwen-Hinderling, Helene Duez, Philippe Lefebvre, Nicolaas C. Schaper, Matthijs K.C. Hesselink, Bart Staels, Patrick Schrauwen
Publikováno v:
Molecular Metabolism, Vol 5, Iss 8, Pp 635-645 (2016)
Objective: A disturbed day-night rhythm is associated with metabolic perturbations that can lead to obesity and type 2 diabetes mellitus (T2DM). In skeletal muscle, a reduced oxidative capacity is also associated with the development of T2DM. However
Externí odkaz:
https://doaj.org/article/9f303dfa6f434cfeb3d0dccd2ca4cb13
Autor:
Dennis Dahlmans, Alexandre Houzelle, Johanna A. Jörgensen, Esther Phielix, Lucas Lindeboom, Matthijs K. C. Hesselink, Patrick Schrauwen, Joris Hoeks
Publikováno v:
Frontiers in Physiology, Vol 8 (2017)
In recent years, several microRNAs (miRNAs)—post-transcriptional regulators of gene expression—have been linked to the regulation of peripheral insulin sensitivity. Many of these studies, however, have been conducted in cell or animal models and
Externí odkaz:
https://doaj.org/article/fb063f050d0b492bb36298f86cafb8fa