Zobrazeno 1 - 10
of 139
pro vyhledávání: '"Johanna A Joyce"'
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0184765 (2017)
Iron-deposition is a metabolic biomarker of macrophages in both normal and pathological situations, but the presence of iron in tumor and metastasis-associated macrophages is not known. Here we mapped and quantified hemosiderin-laden macrophage (HLM)
Externí odkaz:
https://doaj.org/article/244ef897c1cc4d759e6e0e76b1584aa3
Autor:
Spencer S. Watson, Benoit Duc, Ziqi Kang, Axel de Tonnac, Nils Eling, Laure Font, Tristan Whitmarsh, Matteo Massara, iMAXT Consortium, Bernd Bodenmiller, Jean Hausser, Johanna A. Joyce
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract The tumor microenvironment plays a crucial role in determining response to treatment. This involves a series of interconnected changes in the cellular landscape, spatial organization, and extracellular matrix composition. However, assessing
Externí odkaz:
https://doaj.org/article/eaf2eec4622b451e8d2ad39be042dd33
Publikováno v:
PLoS Pathogens, Vol 11, Iss 3, p e1004704 (2015)
The intracellular bacterial pathogen Legionella pneumophila provokes strong host responses and has proven to be a valuable model for the discovery of novel immunosurveillance pathways. Our previous work revealed that an environmental isolate of L. pn
Externí odkaz:
https://doaj.org/article/ff16dd8cfcb84c81a4dd203085f62d22
Autor:
Nicola R Brindle, Johanna A Joyce, Fanya Rostker, Elizabeth R Lawlor, Lamorna Swigart-Brown, Gerard Evan, Douglas Hanahan, Ksenya Shchors
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0120348 (2015)
Motivated by the recent implication of cysteine protease cathepsin L as a potential target for anti-cancer drug development, we used a conditional MycERTAM;Bcl-xL model of pancreatic neuroendocrine tumorigenesis (PNET) to assess the role of cathepsin
Externí odkaz:
https://doaj.org/article/da790047e19d4ab399aa84d387217271
Autor:
Peihong Dai, Weiyi Wang, Hua Cao, Francesca Avogadri, Lianpan Dai, Ingo Drexler, Johanna A Joyce, Xiao-Dong Li, Zhijian Chen, Taha Merghoub, Stewart Shuman, Liang Deng
Publikováno v:
PLoS Pathogens, Vol 10, Iss 4, p e1003989 (2014)
Modified vaccinia virus Ankara (MVA) is an attenuated poxvirus that has been engineered as a vaccine against infectious agents and cancers. Our goal is to understand how MVA modulates innate immunity in dendritic cells (DCs), which can provide insigh
Externí odkaz:
https://doaj.org/article/17de4a22ac0548bfa09a32d25f4bb012
Autor:
Matteo Massara, Bastien Dolfi, Vladimir Wischnewski, Emma Nolan, Werner Held, Ilaria Malanchi, Johanna A. Joyce
Publikováno v:
iScience, Vol 27, Iss 7, Pp 110284- (2024)
Summary: Brain metastases are the most common brain tumors in patients and are associated with poor prognosis. Investigating the colonization and outgrowth of brain metastases is challenging given the complexity of the organ, tissue sampling difficul
Externí odkaz:
https://doaj.org/article/da5428f9bf474c7dbe061ce7a1009de5
Autor:
Mabel Ryder, Matti Gild, Tobias M Hohl, Eric Pamer, Jeff Knauf, Ronald Ghossein, Johanna A Joyce, James A Fagin
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e54302 (2013)
Advanced human thyroid cancers are densely infiltrated with tumor-associated macrophages (TAMs) and this correlates with a poor prognosis. We used BRAF-induced papillary thyroid cancer (PTC) mouse models to examine the role of TAMs in PTC progression
Externí odkaz:
https://doaj.org/article/f76ca976c2404ff3973961c41de19d31
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e64472 (2013)
Pancreatic neuroendocrine tumors (PanNETs) are a relatively rare but clinically challenging tumor type. In particular, high grade, poorly-differentiated PanNETs have the worst patient prognosis, and the underlying mechanisms of disease are poorly und
Externí odkaz:
https://doaj.org/article/901060c9e8b44fdfb718adae66605319
Autor:
Elias Gounaris, Ching H Tung, Clifford Restaino, René Maehr, Rainer Kohler, Johanna A Joyce, Hidde L Ploegh, Terrence A Barrett, Ralph Weissleder, Khashayarsha Khazaie
Publikováno v:
PLoS ONE, Vol 3, Iss 8, p e2916 (2008)
It has been estimated that up to 30% of detectable polyps in patients regress spontaneously. One major challenge in the evaluation of effective therapy of cancer is the readout for tumor regression and favorable biological response to therapy. Induci
Externí odkaz:
https://doaj.org/article/0e7e97ea6d1c4877b8a9a8df4041f2e7
Publikováno v:
STAR Protocols, Vol 4, Iss 2, Pp 102197- (2023)
Summary: Intravital two-photon microscopy of the mouse brain requires visual access without affecting normal cognitive functions, which is crucial for longitudinal imaging studies that may last several months. In this protocol, we describe the surgic
Externí odkaz:
https://doaj.org/article/5473cab11ebb4ef2bc5e03a33d0eddc9