Výsledky vyhledávání - "Johanna, Viiri"

Pinosylvin Extract Retinari™ Sustains Electrophysiological Function, Prevents Thinning of Retina, and Enhances Cellular Response to Oxidative Stress in NFE2L2 Knockout Mice

Autor: Toni Tamminen, Ali Koskela, Elisa Toropainen, Iswariyaraja Sridevi Gurubaran, Mateusz Winiarczyk, Mikko Liukkonen, Jussi J. Paterno, Petri Lackman, Amir Sadeghi, Johanna Viiri, Juha M. T. Hyttinen, Ari Koskelainen, Kai Kaarniranta

Publikováno v: Oxidative Medicine and Cellular Longevity, Vol 2021 (2021)
Oxidative Medicine and Cellular Longevity

Publisher Copyright: © 2021 Toni Tamminen et al. Chronic oxidative stress eventually leads to protein aggregation in combination with impaired autophagy, which has been observed in age-related macular degeneration. We have previously shown an effect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab82c487c852ee58dd16b3c0f646a248
https://aaltodoc.aalto.fi/handle/123456789/112590

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Epithelial-Mesenchymal Transition and Senescence in the Retinal Pigment Epithelium of

Autor: Janusz, Blasiak, Ali, Koskela, Elzbieta, Pawlowska, Mikko, Liukkonen, Johanna, Ruuth, Elisa, Toropainen, Juha M T, Hyttinen, Johanna, Viiri, John E, Eriksson, Heping, Xu, Mei, Chen, Szabolcs, Felszeghy, Kai, Kaarniranta

Publikováno v: International Journal of Molecular Sciences

Age-related macular degeneration (AMD) is the most prevalent form of irreversible blindness worldwide in the elderly population. In our previous studies, we found that deficiencies in the nuclear factor, erythroid 2 like 2 (NFE2L2) and peroxisome pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bd000372a21fcbbe07f43e1202a56d96
https://pubmed.ncbi.nlm.nih.gov/33567500

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Akademický článek

Autophagy activation clears ELAVL1/HuR-mediated accumulation of SQSTM1/p62 during proteasomal inhibition in human retinal pigment epithelial cells.

Autor: Johanna Viiri, Marialaura Amadio, Nicoletta Marchesi, Juha M T Hyttinen, Niko Kivinen, Reijo Sironen, Kirsi Rilla, Saeed Akhtar, Alessandro Provenzani, Vito Giuseppe D'Agostino, Stefano Govoni, Alessia Pascale, Hansjurgen Agostini, Goran Petrovski, Antero Salminen, Kai Kaarniranta

Publikováno v: PLoS ONE, Vol 8, Iss 7, p e69563 (2013)

Age-related macular degeneration (AMD) is the most common reason of visual impairment in the elderly in the Western countries. The degeneration of retinal pigment epithelial cells (RPE) causes secondarily adverse effects on neural retina leading to v

Externí odkaz: https://doaj.org/article/d6824d07b1854c9eade85e2d16f9a8be

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Loss of NRF-2 and PGC-1α genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration

Publikováno v: Felszeghy, S, Viiri, J, Paterno, J J, Hyttinen, J M T, Koskela, A, Chen, M, Leinonen, H, Tanila, H, Kivinen, N, Koistinen, A, Toropainen, E, Amadio, M, Smedowski, A, Reinisalo, M, Winiarczyk, M, Mackiewicz, J, Mutikainen, M, Ruotsalainen, A K, Kettunen, M, Jokivarsi, K, Sinha, D, Kinnunen, K, Petrovski, G, Blasiak, J, Bjørkøy, G, Koskelainen, A, Skottman, H, Urtti, A, Salminen, A, Kannan, R, Ferrington, D A, Xu, H, Levonen, A L, Tavi, P, Kauppinen, A & Kaarniranta, K 2019, ' Loss of NRF-2 and PGC-1α genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration ', Redox Biology, vol. 20, pp. 1-12 . https://doi.org/10.1016/j.redox.2018.09.011
Felszeghy, Viiri, Paterno, Hyttinen, Koskela,, Chen, M, Leinonen, Tanila, Kivinen, Koistinen, Totopainen, Amadio, Smedowski, Reinisalo, Winiarczyk, Mackiewicz, Mutikainen,, Xu, H & Kaarniranta 2019, ' Loss of NRF-2 and PGC-1a genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration ' Redox Biology, vol. 20, pp. 1-12 . https://doi.org/10.1016/j.redox.2018.09.011
Redox Biology
Redox Biology, Vol 20, Iss, Pp 1-12 (2019)

Age-related macular degeneration (AMD) is a multi-factorial disease that is the leading cause of irreversible and severe vision loss in the developed countries. It has been suggested that the pathogenesis of dry AMD involves impaired protein degradat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1677e813524eb053eea0a201382fedab
https://doi.org/10.1016/j.redox.2018.09.011

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Topical cis-urocanic acid prevents ocular surface irritation in both IgE -independent and -mediated rat model

Autor: Reijo Sironen, Jarmo Laihia, Johanna Viiri, Hanna-Mari Jauhonen, Kai Kaarniranta, Päivi Alajuuma, Lasse Leino, Olli Oksala

Publikováno v: Graefe's Archive for Clinical and Experimental Ophthalmology. 255:2357-2362

Our purpose was to investigate the effect of locally administered cis-urocanic (cis-UCA) in two experimental models of allergic conjunctivitis. The compound 48/80 (C48/80)-induced ocular irritation model (IgE-independent) and the ovalbumin (OA)-induc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03f8bbb831c5d96d5b78ff9236d8e515
https://doi.org/10.1007/s00417-017-3781-z

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Loss of Nrf-2 and PGC1-alpha genes changes macromorphology of the eye and evokes microstructural and pigmentation pattern changes of the retinal pigmented epithelium

Autor: Kai Kaarniranta, Mikko I. Kettunen, Ali Koskela, Kimmo Jokivarsi, Jussi J. Paterno, Johanna Viiri, Szabolcs Felszeghy

Publikováno v: Acta Ophthalmologica. 95

Purpose Nrf2 (NF-E2-related factor 2) and PGC1- α (peroxisome proliferator-activated receptor-gamma coactivator 1-alpha) regulate oxidative stress response in cells. Nrf-2 and PGC1-alpha double-knock-out (dKO) mice were used to monitor macro and mor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d90cf71734d4abcb07748d54c44a03ad
https://doi.org/10.1111/j.1755-3768.2017.01375

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