Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Johanna, Michl"'
Autor:
Johanna Michl, Stefania Monterisi, Bobby White, Wiktoria Blaszczak, Alzbeta Hulikova, Gulnar Abdullayeva, Esther Bridges, Zinan Yin, Walter F. Bodmer, Pawel Swietach
Publikováno v:
Cell Reports, Vol 42, Iss 6, Pp 112601- (2023)
Summary: Acidic environments reduce the intracellular pH (pHi) of most cells to levels that are sub-optimal for growth and cellular functions. Yet, cancers maintain an alkaline cytoplasm despite low extracellular pH (pHe). Raised pHi is thought to be
Externí odkaz:
https://doaj.org/article/fa74c4cb09b5443a9fcec040cffeaf11
Autor:
Stefania Monterisi, Johanna Michl, Alzbeta Hulikova, Jana Koth, Esther M Bridges, Amaryllis E Hill, Gulnar Abdullayeva, Walter F Bodmer, Pawel Swietach
Publikováno v:
eLife, Vol 11 (2022)
Growth of cancer cells in vitro can be attenuated by genetically inactivating selected metabolic pathways. However, loss-of-function mutations in metabolic pathways are not negatively selected in human cancers, indicating that these genes are not ess
Externí odkaz:
https://doaj.org/article/6873e0339c734b01bab661f7fa921019
Autor:
Johanna Michl, Yunyi Wang, Stefania Monterisi, Wiktoria Blaszczak, Ryan Beveridge, Esther M. Bridges, Jana Koth, Walter F. Bodmer, Pawel Swietach
Publikováno v:
Cell Reports, Vol 38, Iss 10, Pp 110493- (2022)
Summary: Unlike most cell types, many cancer cells survive at low extracellular pH (pHe), a chemical signature of tumors. Genes that facilitate survival under acid stress are therefore potential targets for cancer therapies. We performed a genome-wid
Externí odkaz:
https://doaj.org/article/696d8f39d93a4311848ebb92e14a06d8
Autor:
Eliana MC Tacconi, Xianning Lai, Cecilia Folio, Manuela Porru, Gijs Zonderland, Sophie Badie, Johanna Michl, Irene Sechi, Mélanie Rogier, Verónica Matía García, Ankita Sati Batra, Oscar M Rueda, Peter Bouwman, Jos Jonkers, Anderson Ryan, Bernardo Reina‐San‐Martin, Joannie Hui, Nelson Tang, Alejandra Bruna, Annamaria Biroccio, Madalena Tarsounas
Publikováno v:
EMBO Molecular Medicine, Vol 9, Iss 10, Pp 1398-1414 (2017)
Abstract Maintenance of genome integrity requires the functional interplay between Fanconi anemia (FA) and homologous recombination (HR) repair pathways. Endogenous acetaldehyde, a product of cellular metabolism, is a potent source of DNA damage, par
Externí odkaz:
https://doaj.org/article/6bb88c58f3cf4cfc896831d828ae3700
Publikováno v:
Frontiers in Pharmacology, Vol 8 (2017)
Species of Asarum are used in traditional Chinese medicine and, similar to members of the genus Aristolochia, they contain aristolochic acid analogs (AAAs). These compounds are known for their nephrotoxic and carcinogenic effects. So far, the phytoch
Externí odkaz:
https://doaj.org/article/f69e5415119f43f7b734111f854666de
Autor:
Stefania Monterisi, Johanna Michl, Alzbeta Hulikova, Jana Koth, Esther M Bridges, Amaryllis E Hill, Gulnar Abdullayeva, Walter F Bodmer, Pawel Swietach
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::31f5e89ff04b27cea6702ec9f97ad706
https://doi.org/10.7554/elife.78425.sa2
https://doi.org/10.7554/elife.78425.sa2
Publikováno v:
Communications Biology, Vol 2, Iss 1, Pp 1-12 (2019)
Communications Biology
Communications Biology
A fundamental variable in culture medium is its pH, which must be controlled by an appropriately formulated buffering regime, since biological processes are exquisitely sensitive to acid–base chemistry. Although awareness of the importance of pH is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bd9afa386f40a5b10c099d20e391c0c
http://link.springer.com/article/10.1038/s42003-019-0393-7
http://link.springer.com/article/10.1038/s42003-019-0393-7
Autor:
Stefan Wanke, Monique S. J. Simmonds, G. Vollmer, Geoffrey C. Kite, Christoph Neinhuis, Johanna Michl, Michael Heinrich, Oliver Zierau
Publikováno v:
Journal of Natural Products. 79:30-37
Species of Aristolochia are used as herbal medicines worldwide. They cause aristolochic acid nephropathy (AAN), a devastating disease associated with kidney failure and renal cancer. Aristolochic acids I and II (1 and 2) are considered to be responsi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e86360941864b247a774d4f1eb288da
https://doi.org/10.1021/acs.jnatprod.5b00556
https://doi.org/10.1021/acs.jnatprod.5b00556
Autor:
Peter Bouwman, Alejandra Bruna, Sophie Badie, Verónica Matía García, Joannie Hui, Irene Sechi, Ankita Sati Batra, Nelson L.S. Tang, Xianning Lai, Mélanie Rogier, Manuela Porru, Cecilia Folio, Madalena Tarsounas, Annamaria Biroccio, Johanna Michl, Eliana M.C. Tacconi, Oscar M. Rueda, Gijs Zonderland, Jos Jonkers, Anderson J. Ryan, Bernardo Reina-San-Martin
Publikováno v:
EMBO Molecular Medicine
EMBO Molecular Medicine, 2017, 9 (10), pp.1398-1414. ⟨10.15252/emmm.201607446⟩
EMBO Molecular Medicine, 2017, 9 (10), pp.1398-1414. ⟨10.15252/emmm.201607446⟩
Maintenance of genome integrity requires the functional interplay between Fanconi anemia (FA) and homologous recombination (HR) repair pathways. Endogenous acetaldehyde, a product of cellular metabolism, is a potent source of DNA damage, particularly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c44e4a8aec1237d00414501e22a7ccce
http://ora.ox.ac.uk/objects/uuid:
http://ora.ox.ac.uk/objects/uuid:
Autor:
Johanna Michl, Michael Heinrich, Hannah Jennings, Martin Ingrouille, Geoffrey C. Kite, Monique S. J. Simmonds
Publikováno v:
Journal of Ethnopharmacology. 149(1):235-244
Species of Aristolochia are associated with aristolochic acid nephropathy (AAN), a renal interstitial fibrosis and upper urinary tract cancer (UUC). Aristolochic acid nephropathy has been reported in ten countries but its true incidence is unknown an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd03d1c51b4dad2323856c2d7dbbccd3