Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Johann Schredelseker"'
Autor:
Juan Sierra-Marquez, Lena Schaller, Lukas Sassenbach, Antonio Ramírez-Fernández, Philipp Alt, Björn Rissiek, Béla Zimmer, Johann Schredelseker, Julia Hector, Tobias Stähler, Friedrich Koch-Nolte, Claudia A. Staab-Weijnitz, Alexander Dietrich, Robin Kopp, Annette Nicke
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionP2X receptors are a family of homo- and heterotrimeric cation channels gated by extracellular ATP. The P2X4 and P2X7 subunits show overlapping expression patterns and have been involved in similar physiological processes, such as pain and
Externí odkaz:
https://doaj.org/article/b55a6bb7bcc24c3691c0c6357b0bf403
Autor:
Thirupura S. Shankar, Dinesh K. A. Ramadurai, Kira Steinhorst, Salah Sommakia, Rachit Badolia, Aspasia Thodou Krokidi, Dallen Calder, Sutip Navankasattusas, Paulina Sander, Oh Sung Kwon, Aishwarya Aravamudhan, Jing Ling, Andreas Dendorfer, Changmin Xie, Ohyun Kwon, Emily H. Y. Cheng, Kevin J. Whitehead, Thomas Gudermann, Russel S. Richardson, Frank B. Sachse, Johann Schredelseker, Kenneth W. Spitzer, Dipayan Chaudhuri, Stavros G. Drakos
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
The authors found that VDAC2 plays a crucial role in influencing mitochondrial calcium dynamics and cellular calcium signalling. A VDAC2 agonist, efsevin, rescued the heart failure phenotype, identifying a new potential therapeutic target for heart f
Externí odkaz:
https://doaj.org/article/5def0b8a41bf407088eed68a7df3942d
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 1, p 269 (2022)
The voltage-dependent anion channel (VDAC) is the main passageway for ions and metabolites over the outer mitochondrial membrane. It was associated with many physiological processes, including apoptosis and modulation of intracellular Ca2+ signaling.
Externí odkaz:
https://doaj.org/article/3d29d84f4f4d4dfe831d502ec4fac5c0
Autor:
Hirohito Shimizu, Simon Huber, Adam D. Langenbacher, Lauren Crisman, Jie Huang, Kevin Wang, Fabiola Wilting, Thomas Gudermann, Johann Schredelseker, Jau-Nian Chen
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Mitochondria critically regulate a range of cellular processes including bioenergetics, cellular metabolism, apoptosis, and cellular Ca2+ signaling. The voltage-dependent anion channel (VDAC) functions as a passageway for the exchange of ions, includ
Externí odkaz:
https://doaj.org/article/f1a4486601394aacbc108e43e8005254
Autor:
Jonas Weber, Suhasini Rajan, Christian Schremmer, Yu-Kai Chao, Gabriela Krasteva-Christ, Martina Kannler, Ali Önder Yildirim, Monika Brosien, Johann Schredelseker, Norbert Weissmann, Christian Grimm, Thomas Gudermann, Alexander Dietrich
Publikováno v:
JCI Insight, Vol 5, Iss 20 (2020)
Ischemia/reperfusion-induced edema (IRE), one of the most significant causes of mortality after lung transplantation, can be mimicked ex vivo in isolated perfused mouse lungs (IPL). Transient receptor potential vanilloid 4 (TRPV4) is a nonselective c
Externí odkaz:
https://doaj.org/article/d3fe98c2aa904e21a2c8a6614a7c1fee
Autor:
Susanne Gerndt, Cheng-Chang Chen, Yu-Kai Chao, Yu Yuan, Sandra Burgstaller, Anna Scotto Rosato, Einar Krogsaeter, Nicole Urban, Katharina Jacob, Ong Nam Phuong Nguyen, Meghan T Miller, Marco Keller, Angelika M Vollmar, Thomas Gudermann, Susanna Zierler, Johann Schredelseker, Michael Schaefer, Martin Biel, Roland Malli, Christian Wahl-Schott, Franz Bracher, Sandip Patel, Christian Grimm
Publikováno v:
eLife, Vol 9 (2020)
Ion selectivity is a defining feature of a given ion channel and is considered immutable. Here we show that ion selectivity of the lysosomal ion channel TPC2, which is hotly debated (Calcraft et al., 2009; Guo et al., 2017; Jha et al., 2014; Ruas et
Externí odkaz:
https://doaj.org/article/64c41b16eef7442a8eaf94088d92df5d
Autor:
Maria K. Schweitzer, MSc, Fabiola Wilting, MSc, Simon Sedej, PhD, Lisa Dreizehnter, PhD, Nathan J. Dupper, BSc, Qinghai Tian, PhD, Alessandra Moretti, PhD, Ilaria My, MD, Ohyun Kwon, PhD, Silvia G. Priori, MD, PhD, Karl-Ludwig Laugwitz, MD, Ursula Storch, PhD, Peter Lipp, PhD, Andreas Breit, PhD, Michael Mederos y Schnitzler, PhD, Thomas Gudermann, MD, Johann Schredelseker, PhD
Publikováno v:
JACC: Basic to Translational Science, Vol 2, Iss 6, Pp 737-747 (2017)
Cardiovascular disease-related deaths frequently arise from arrhythmias, but treatment options are limited due to perilous side effects of commonly used antiarrhythmic drugs. Cardiac rhythmicity strongly depends on cardiomyocyte Ca2+ handling and pre
Externí odkaz:
https://doaj.org/article/a17d99e526834f97a47d3d5c80e71635
Autor:
Silvia Ferioli, Susanna Zierler, Joanna Zaißerer, Johann Schredelseker, Thomas Gudermann, Vladimir Chubanov
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-19 (2017)
Abstract TRPM6 and its homologue TRPM7 are α-kinase-coupled divalent cation-selective channels activated upon reduction of cytosolic levels of Mg2+ and Mg·ATP. TRPM6 is vital for organismal Mg2+ balance. However, mechanistically the cellular role a
Externí odkaz:
https://doaj.org/article/ed61a16c849844f1ac78a313b8afcf6c
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 2, p 946 (2021)
Already in the early 1960s, researchers noted the potential of mitochondria to take up large amounts of Ca2+. However, the physiological role and the molecular identity of the mitochondrial Ca2+ uptake mechanisms remained elusive for a long time. The
Externí odkaz:
https://doaj.org/article/54d9953a9c0046b3856b4a4c1863c7d8
Autor:
Hirohito Shimizu, Johann Schredelseker, Jie Huang, Kui Lu, Shamim Naghdi, Fei Lu, Sarah Franklin, Hannah DG Fiji, Kevin Wang, Huanqi Zhu, Cheng Tian, Billy Lin, Haruko Nakano, Amy Ehrlich, Junichi Nakai, Adam Z Stieg, James K Gimzewski, Atsushi Nakano, Joshua I Goldhaber, Thomas M Vondriska, György Hajnóczky, Ohyun Kwon, Jau-Nian Chen
Publikováno v:
eLife, Vol 4 (2015)
Tightly regulated Ca2+ homeostasis is a prerequisite for proper cardiac function. To dissect the regulatory network of cardiac Ca2+ handling, we performed a chemical suppressor screen on zebrafish tremblor embryos, which suffer from Ca2+ extrusion de
Externí odkaz:
https://doaj.org/article/2f19b0f5e68e46e088b8efd2e64e693f