Use of Viral Load as a Surrogate Marker in Clinical Studies of Cytomegalovirus in Solid Organ Transplantation: A Systematic Review and Meta-analysis

Autor: Gary Fahle, Robin K. Avery, Debra Birnkrant, Jeffrey C. Murray, Yoshihiko Murata, Mary Singer, Randi Y. Leavitt, Hans H. Hirsch, Lynn Fallon, Francisco Martinez-Murillo, John E. McKinnon, Gavin Cloherty, Randall Lanier, Rekha Abichandani, Philip R. Krause, Sally Mossman, M Michelle Berrey, Wael Saber, Ali Alghamdi, John A. D. Leake, Raymund R. Razonable, Takashi E. Komatsu, Emily A. Blumberg, Mahmood Tazari, Kurt Gunter, Thomas Mertens, Jens D Lundgren, Yoichiro Natori, Sunwen Chou, Kevin Modarress, Jay Erdman, Li Li, Terry Bowlin, Peter W. Hunt, William Cruikshank, Anna Wijatyk, Frank Kuhr, Garrett Nichols, Aimee Hodowanec, Marcie L. Riches, Shahid Husain, Karl S. Peggs, Jules O'Rear, Johann Mols, Filip Josephson, Christopher Lademacher, Paul Baum, Bernhardt Zeiher, Paul D. Griffiths, Susan Barnett, Mark N. Prichard, Michael Boeckh, Roy F. Chemaly, Megan McCutcheon, Thomas Stamminger, Fausto Baldanti, Chalom Sayada, Veronica Miller, Andreas Pikis, Atul Humar, Dimitri Gonzalez, Barbara D. Alexander, Jennifer Brooks, Jeff Roberts, Camille N. Kotton, Hermann Einsele, Tadd Lazarus, David Boutolleau, Deepali Kumar, Sandra Nusinoff Lehrman, Ani Orchanian-Cheff, Howard Mayer, Heather Gillis, Dong Yu, David Murawski, Per Ljungman, Paula Isabelle Lodding, Lesia K. Dropulic

Publikováno v: Clinical Infectious Diseases. 66:617-631

Symptomatic cytomegalovirus (CMV) disease has been the standard endpoint for clinical trials in organ transplant recipients. Viral load may be a more relevant endpoint due to low frequency of disease. We performed a meta-analysis and systematic revie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad9869816a9bd64d42d0d7ab0a61e725
https://doi.org/10.1093/cid/cix793

Toxicology, biodistribution and shedding profile of a recombinant measles vaccine vector expressing HIV-1 antigens, in cynomolgus macaques

Autor: Gerald Voss, Nicolas Dumey, Johann Mols, Olga Rovira, Clarisse Lorin, Frédérick Le Goff, Patricia Bourguignon, Pascal Mettens, Frédéric Tangy, Jérémy Silvano, Lawrence Segal, Marguerite Koutsoukos, Danielle Morelle

Publikováno v: Naunyn-Schmiedeberg's Archives of Pharmacology

As a new human immunodeficiency virus type 1 (HIV-1) vaccine approach, the live-attenuated measles virus (MV) Schwarz vaccine strain was genetically engineered to express the F4 antigen (MV1-F4). F4 is a fusion protein comprising HIV-1 antigens p17 a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a175799767cd4316d5942ae3fc71817c

TNF-α stimulation inhibits siRNA-mediated RNA interference through a mechanism involving poly-(A) tail stabilization

Autor: Jianming Chen, Motoyuki Otsuka, Jiahuai Han, Johann Mols, Arjen van den Berg, Min Zheng

Publikováno v: Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 1779:712-719

The control of mRNA stability is a complex biological process that involves numerous factors, including microRNA (miRNA) and short interfering RNA (siRNA). Here, we show that short interfering RNA (siRNA) and microRNA share some similarities in their

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41fe8c6623f341193b6a6f2da0be0303
https://doi.org/10.1016/j.bbagrm.2008.03.007

Vesicular stomatitis virus glycoprotein G activates a specific antiviral Toll-like receptor 4-dependent pathway

Autor: Zhengfan Jiang, Philippe Georgel, Siamak Bahram, Stefan Kunz, Edith M. Janssen, Kasper Hoebe, Michael B. A. Oldstone, Bruce Beutler, Johann Mols

Publikováno v: Virology. 362:304-313

We have previously shown that mutations of CD14 or TLR4 impair type I interferon (IFN) production and macrophage survival during infection with vesicular stomatitis virus (VSV). We now report that VSV glycoprotein G (gpG) is essential for the inducti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::813b242c36b8e5c3301d177fac48bcb4
https://doi.org/10.1016/j.virol.2006.12.032

Origin of rice protein hydrolysates added to protein-free media alters secretion and extracellular proteolysis of recombinant interferon-γ as well as CHO-320 cell growth

Autor: Yves-Jacques Schneider, Chantal Peeters-Joris, Johann Mols, Spiros N. Agathos

Publikováno v: Biotechnology Letters. 26:1043-1046

CHO-320 cells, cultivated in suspension in a protein-free medium supplemented with rice protein hydrolysates (peptones), secrete recombinant interferon-gamma (IFN-gamma) that undergo will or will not proteolysis, depending on the origin of the pepton

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbcb0d79a99aa3fbc45ed08233d3ce78
https://doi.org/10.1023/b:bile.0000032960.06112.31