Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Johann Leban"'
Autor:
Eduardo R. Perez Gonzalez, Bernhard Reck, Predrag Kalaba, Thierry Langer, Johann Leban, Gert Lubec
Publikováno v:
ACS Omega, Vol 9, Iss 11, Pp 12976-12983 (2024)
Externí odkaz:
https://doaj.org/article/da11b6c4b27740f188034b91c23b8dd8
Autor:
Friederike Schmidt, Michael Weller, Johann Leban, Günter Eisele, Caroline Herrmann, Maria Kissel, Patrick Roth
Supplementary Data from SC68896, a Novel Small Molecule Proteasome Inhibitor, Exerts Antiglioma Activity In vitro and In vivo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f89c3e912b03b35c970f5afbec63483
https://doi.org/10.1158/1078-0432.22440580.v1
https://doi.org/10.1158/1078-0432.22440580.v1
Autor:
Friederike Schmidt, Michael Weller, Johann Leban, Günter Eisele, Caroline Herrmann, Maria Kissel, Patrick Roth
Purpose: Glioblastomas are among the most lethal neoplasms, with a median survival of Experimental Design: Different tumor cell lines were tested by crystal violet staining for sensitivity to SC68896, given alone or in combination with death ligands.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::051f70e6337bc9a3686825ba225d8043
https://doi.org/10.1158/1078-0432.c.6517885
https://doi.org/10.1158/1078-0432.c.6517885
Autor:
Johann Leban
Publikováno v:
Biomedical Journal of Scientific & Technical Research. 47
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2be65661d0bce1b3eb74e335960d30aa
https://doi.org/10.26717/bjstr.2022.47.007542
https://doi.org/10.26717/bjstr.2022.47.007542
Autor:
Marija Ilic, Jana Lubec, Alexander Roller, Vladimir Dragačević, Jovana Malikovic, Shima Kouhnavardi, Johann Leban, Roberto Plasenzotti, Simone B. Sartori, Thierry Langer, Predrag Kalaba, Marco Pistis, Judith Wackerlig, Christian Pifl, Daniel Daba Feyissa, Martin Zehl, Karl Ebner, Nicolas Singewald, Ernst Urban, Claudia Sagheddu, Arthur Garon, Mohamed H. Kotob, Ahmed M. Hussein, Rasha Refaat Mahmmoud, Francisco J. Monje, Natalie Gajic, Anita Cybulska-Klosowicz, Oliver Wieder, Gert Lubec, Harald H. Sitte, Volker Korz
Publikováno v:
Molecular Psychiatry. 26:7076-7090
Aging-related neurological deficits negatively impact mental health, productivity, and social interactions leading to a pronounced socioeconomic burden. Since declining brain dopamine signaling during aging is associated with the onset of neurologica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d36e133840b3bd448c5a3aff8da2b66
https://doi.org/10.1038/s41380-021-01214-x
https://doi.org/10.1038/s41380-021-01214-x
Autor:
Predrag Kalaba, Steffen Hering, Vladimir Dragačević, Eduardo René Pérez González, Marija Ilic, Philip John Neill, Jawad Akbar Khan, Tetyana Beryozkina, Karl Ebner, Nilima Y. Aher, Alexander Roller, Martin Zehl, Johann Leban, Thierry Langer, Simone B. Sartori, Harald H. Sitte, Marcus Wieder, Gert Lubec, Natalie Lukic, Christian Pifl, Nicolas Singewald, Jana Lubec, Stanislav Beyl, Vasiliy A. Bakulev, Judith Wackerlig, Ernst Urban
Publikováno v:
Journal of medicinal chemistry. 63(1)
Atypical dopamine reuptake inhibitors, such as modafinil, are used for the treatment of sleeping disorders and investigated as potential therapeutics against cocaine addiction and for cognitive enhancement. Our continuous effort to find modafinil ana
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79bce31f07f75eed1e9e8b5a07a6c8f8
https://pubmed.ncbi.nlm.nih.gov/31841637
https://pubmed.ncbi.nlm.nih.gov/31841637
Autor:
Vasiliy A. Bakulev, Thierry Langer, Harald H. Sitte, Gerhard F. Ecker, Johann Leban, Minu Karthika Ganesan, Ajinkya Sase, Harald Höger, Sivaprakasam R. Saroja, Yogesh D. Aher, Marion Holy, Gert Lubec, Sunetra Sase
Publikováno v:
Neuropharmacology. 102:186-196
A series of compounds have been reported to enhance memory via the DA system and herein a heterocyclic compound was tested for working memory (WM) enhancement. 2-((benzhydrylsulfinyl)methyl)thiazole (CE-103) was synthesized in a six-step synthesis. B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c97d4806815ec3ef0fcfdaba8acdb266
https://doi.org/10.1016/j.neuropharm.2015.07.039
https://doi.org/10.1016/j.neuropharm.2015.07.039
Autor:
Vera S. Berseneva, Gert Lubec, Predrag Kalaba, Tetyana Beryozkina, Lidia Dianova, Pavel A. Slepukhin, Johann Leban, Vasiliy A. Bakulev, Harald H. Sitte, Marija Ilic, Nilima Y. Aher
Publikováno v:
Synthesis. 48:1046-1054
A design and a convenient approach for the synthesis of novel N-sulfonyl-2-diphenylmethylsulfinylacetamidines have been demonstrated by starting from benzhydrylsulfanylacetic (BSA) acid. This approach involves a sequential amidation with amines, thio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e5958e3bd51e44fc3051d1ea5acb0501
https://doi.org/10.1055/s-0035-1561350
https://doi.org/10.1055/s-0035-1561350
Autor:
Fabian Wesseler, Uwe Knippschild, Dennis Schade, Balbina García-Reyes, Bernd Rathmer, Elena Brunstein, Christian Pichlo, Doris Henne-Bruns, Björn Jansen, Tanja Gehring, Ebru Karasu, Lydia Witt, Ulrich Baumann, Christian Peifer, Johann Leban
Publikováno v:
Journal of medicinal chemistry. 61(9)
Inhibitors of Wnt production (IWPs) are known antagonists of the Wnt pathway, targeting the membrane-bound O-acyltransferase porcupine (Porcn) and thus preventing a crucial Wnt ligand palmitoylation. Since IWPs show structural similarities to benzimi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93411feea3b63a252c669e04fefebccf
https://pubmed.ncbi.nlm.nih.gov/29630366
https://pubmed.ncbi.nlm.nih.gov/29630366
Autor:
Yogesh D. Aher, Vladimir Dragačević, Marcus Wieder, Harald Hoeger, Predrag Kalaba, Lisa Zanon, Marija Ilic, Winfried Neuhaus, Jana Aradska, Martina Kristofova, Gert Lubec, Nilima Y. Aher, Volker Korz, Ernst Urban, Johann Leban, Harald H. Sitte, Thierry Langer, Bojana Radoman
Publikováno v:
Behavioural brain research. 343
Dopamine reuptake inhibitors have been shown to improve cognitive parameters in various tasks and animal models. We recently reported a series of modafinil analogues, of which the most promising, 5-((benzhydrylsulfinyl)methyl) thiazole (CE-123), was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a32f0f43327dfb176200dd631ca80bba
https://pubmed.ncbi.nlm.nih.gov/29410048
https://pubmed.ncbi.nlm.nih.gov/29410048