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Akademický článek

Suitability of Ex Vivo-Expanded Microtic Perichondrocytes for Auricular Reconstruction

Autor: Yvonne Jakob, Johann Kern, David Gvaramia, Philipp Fisch, Ralph Magritz, Sven Reutter, Nicole Rotter

Publikováno v: Cells, Vol 13, Iss 2, p 141 (2024)

Tissue engineering (TE) techniques offer solutions for tissue regeneration but require large quantities of cells. For microtia patients, TE methods represent a unique opportunity for therapies with low donor-site morbidity and reliance on the surgeon

Externí odkaz: https://doaj.org/article/1a8904bfcd3f4d96a6508283ae1e853f

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Akademický článek

Characterization of Distinct Chondrogenic Cell Populations of Patients Suffering from Microtia Using Single-Cell Micro-Raman Spectroscopy

Autor: Dominika Zielinska, Hesham K. Yosef, Tilo Zollitsch, Johann Kern, Yvonne Jakob, David Gvaramia, Nicole Rotter, Luca Pontiggia, Ueli Moehrlen, Thomas Biedermann, Agnes S. Klar

Publikováno v: Biomedicines, Vol 11, Iss 9, p 2588 (2023)

Microtia is a congenital condition of abnormal development of the outer ear. Tissue engineering of the ear is an alternative treatment option for microtia patients. However, for this approach, the identification of high regenerative cartilage progeni

Externí odkaz: https://doaj.org/article/6897733ed6f14453b28e383b284355c1

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Akademický článek

In situ regeneration of nasal septal defects using acellular cartilage enhanced with platelet-derived growth factor

Autor: Lena Huber, David Gvaramia, Johann Kern, Yvonne Jakob, Frank G Zoellner, Daniela Hirsch, Roman Breiter, Rolf E Brenner, Nicole Rotter

Publikováno v: Journal of Tissue Engineering, Vol 13 (2022)

Nasal septum defects can currently only be reconstructed using autologous cartilage grafts. In this study, we examine the reconstruction of septal cartilage defects in a rabbit model using porcine decellularized nasal septal cartilage (DNSC) function

Externí odkaz: https://doaj.org/article/4a8fc47ffff9419b87b1c18355b5d13a

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Akademický článek

Precision Medicine Gains Momentum: Novel 3D Models and Stem Cell-Based Approaches in Head and Neck Cancer

Autor: Annette Affolter, Anne Lammert, Johann Kern, Claudia Scherl, Nicole Rotter

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 9 (2021)

Despite the current progress in the development of new concepts of precision medicine for head and neck squamous cell carcinoma (HNSCC), in particular targeted therapies and immune checkpoint inhibition (CPI), overall survival rates have not improved

Externí odkaz: https://doaj.org/article/cb5998898dd744e497fcf52530672159

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Akademický článek

Spliced XBP1 Levels Determine Sensitivity of Multiple Myeloma Cells to Proteasome Inhibitor Bortezomib Independent of the Unfolded Protein Response Mediator GRP78

Autor: Bojana Borjan, Johann Kern, Normann Steiner, Eberhard Gunsilius, Dominik Wolf, Gerold Untergasser

Publikováno v: Frontiers in Oncology, Vol 9 (2020)

Background: Mechanisms mediating resistance against the proteasome inhibition by bortezomib (BTZ) in multiple myeloma (MM) cells are still unclear. We analyzed the activation of the unfolded protein response (UPR), induction of prosurvival, and apopt

Externí odkaz: https://doaj.org/article/42c479e5f68944c3aa57c4fcfeab2822

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Akademický článek

Development of a 3D angiogenesis model to study tumour – endothelial cell interactions and the effects of anti-angiogenic drugs

Autor: Arno Amann, Marit Zwierzina, Stefan Koeck, Gabriele Gamerith, Elisabeth Pechriggl, Julia M. Huber, Edith Lorenz, Jens M. Kelm, Wolfgang Hilbe, Heinz Zwierzina, Johann Kern

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)

Abstract The tumour microenvironment and tumour angiogenesis play a critical role in the development and therapy of many cancers, but in vitro models reflecting these circumstances are rare. In this study, we describe the development of a novel tri-c

Externí odkaz: https://doaj.org/article/1ee938a72b3246ccbd4db879b442a84b

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Akademický článek

5-Methoxyleoligin, a lignan from Edelweiss, stimulates CYP26B1-dependent angiogenesis in vitro and induces arteriogenesis in infarcted rat hearts in vivo.

Autor: Barbara Messner, Johann Kern, Dominik Wiedemann, Stefan Schwaiger, Adrian Türkcan, Christian Ploner, Alexander Trockenbacher, Klaus Aumayr, Nikolaos Bonaros, Günther Laufer, Hermann Stuppner, Gerold Untergasser, David Bernhard

Publikováno v: PLoS ONE, Vol 8, Iss 3, p e58342 (2013)

Insufficient angiogenesis and arteriogenesis in cardiac tissue after myocardial infarction (MI) is a significant factor hampering the functional recovery of the heart. To overcome this problem we screened for compounds capable of stimulating angiogen

Externí odkaz: https://doaj.org/article/8573bf8bd857429fb69ad860de8328c9

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Optimisation of Conditions for the Formation of Spheroids of Head and Neck Squamous Cell Carcinoma Cell Lines for Use as Animal Alternatives

Autor: Esther Tenschert, Johann Kern, Annette Affolter, Nicole Rotter, Anne Lammert

Publikováno v: Alternatives to laboratory animals : ATLA. 50(6)

The use of in vitro 3-D cell culture models in cancer research has yielded substantial gains in knowledge on various aspects of tumour biology. Such cell culture models could be useful in the study of head and neck squamous cell carcinoma (HNSCC), wh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38792395202d983ee7fcfcf769cd2bde
https://pubmed.ncbi.nlm.nih.gov/36263982

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