Výsledky vyhledávání - "Johann K. Scicluna"

Lipopolysaccharide alters vasodilation to atrial natriuretic peptide via nitric oxide and endothelin-1: Time-dependent effects

Autor: Arnaud Mansart, Charles S. Reilly, Jonathan J. Ross, Johann K. Scicluna, Zoë L. S. Brookes, Nicola J. Brown

Publikováno v: European Journal of Pharmacology. 621:67-70

Nitric oxide (NO) induces vascular relaxation via cGMP in vascular smooth muscle (VSM) and is an important mediator of vascular tone during sepsis, as endothelial NO synthase (eNOS) may be upregulated during the early stages. Atrial natriuretic pepti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::666ec2d3942e1dfa956e3c33189e5ce4
https://doi.org/10.1016/j.ejphar.2009.08.029

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Reduced vascular response to phenylephrine during exposure to lipopolysaccharide in vitro involves nitric oxide and endothelin 1

Autor: Charles S. Reilly, Arnaud Mansart, Zoë L. S. Brookes, Nicola J. Brown, Johann K. Scicluna, Jonathan J. Ross

Publikováno v: Shock (Augusta, Ga.). 29(3)

Nitric oxide (NO) and endothelin 1 (ET-1) increase significantly during the first 4 h of Escherichia coli lipopolysaccharide (LPS) exposure. The aim of this study was to investigate the role of these mediators in the reduced response to phenylephrine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86ed4dbe225e8ddfd7e6560ed2b1e831
https://pubmed.ncbi.nlm.nih.gov/18437715

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