Triterpene Acids from Frankincense and Semi-Synthetic Derivatives That Inhibit 5-Lipoxygenase and Cathepsin G

Autor: Andreas Koeberle, Arne Henkel, Moritz Verhoff, Lars Tausch, Stefanie König, Dagmar Fischer, Nicole Kather, Stefanie Seitz, Michael Paul, Johann Jauch, Oliver Werz

Publikováno v: Molecules, Vol 23, Iss 2, p 506 (2018)

Age-related diseases, such as osteoarthritis, Alzheimer’s disease, diabetes, and cardiovascular disease, are often associated with chronic unresolved inflammation. Neutrophils play central roles in this process by releasing tissue-degenerative prot

Externí odkaz: https://doaj.org/article/611756a5272a4152a328d9b7e7c8b1d0

Metal catalysed versus organocatalysed stereoselective synthesis: The concrete case of myrtucommulones

Autor: Johann Jauch, Maël Charpentier

Publikováno v: Tetrahedron. 73:6614-6623

Myrtucommulones belong to a class of pharmacologically active natural compounds which offer various alternatives to the treatment of pain, inflammation and cancer. Their stereoselective synthesis remains therefore a key-challenge towards its use in t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::07a4235f2ffae1e50431382b22e9a46d
https://doi.org/10.1016/j.tet.2017.10.011

Triterpene Acids from Frankincense and Semi-Synthetic Derivatives That Inhibit 5-Lipoxygenase and Cathepsin G

Autor: Johann Jauch, Nicole Kather, Stefanie Seitz, Michael Paul, Dagmar Fischer, Moritz Verhoff, Arne Henkel, Oliver Werz, Andreas Koeberle, Stefanie König, Lars Tausch

Publikováno v: Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
Molecules; Volume 23; Issue 2; Pages: 506
Molecules, Vol 23, Iss 2, p 506 (2018)

Age-related diseases, such as osteoarthritis, Alzheimer’s disease, diabetes, and cardiovascular disease, are often associated with chronic unresolved inflammation. Neutrophils play central roles in this process by releasing tissue-degenerative prot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e20c4dfc2821cebac014271b19862214
https://pubmed.ncbi.nlm.nih.gov/29495286

Stereoisomeric Composition of Natural Myrtucommulone A

Autor: Gerhard Bringmann, Maël Charpentier, Torsten Bruhn, Marcus Hans, Volker Huch, Dietmar Quandt, Johann Jauch

Publikováno v: Journal of Natural Products. 78:2381-2389

Myrtucommulone A (MC A) (1), isolated from Myrtus communis (myrtle), shows the same pharmacological activity for inhibition of inflammation and induction of apoptosis as synthetic MC A, which consists of three stereoisomers, i.e., two enantiomers and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e121c29ea9edb0a2ff4cfed9be110937
https://doi.org/10.1021/acs.jnatprod.5b00358

Synthesis and biological evaluation of novel myrtucommulones and structural analogues that target mPGES-1 and 5-lipoxygenase

Autor: Katja Wiechmann, Volker Huch, Oliver Werz, David Hartmann, Hans Müller, Johann Jauch

Publikováno v: European Journal of Medicinal Chemistry. 101:133-149

The natural acylphloroglucinol myrtucommulone A (1) inhibits microsomal prostaglandin E2 synthase (mPGES)-1 and 5-lipoxygenase (5-LO), and induces apoptosis of cancer cells. Starting from 1 as lead, 28 analogues were synthesized following a straightf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::092654d52d7af52a958af9d4cda58fda
https://doi.org/10.1016/j.ejmech.2015.06.001