Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Johann Holzmann"'
Autor:
Therese Wohlschlager, Kai Scheffler, Ines C. Forstenlehner, Wolfgang Skala, Stefan Senn, Eugen Damoc, Johann Holzmann, Christian G. Huber
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
The specific glycosylation patterns of biological drugs often impact the efficacy and safety of the therapeutic product. Here the authors describe a native mass spectrometry approach that allows the resolution of highly complex glycosylation patterns
Externí odkaz:
https://doaj.org/article/652a3252f9884ca095fe82ff547d3b84
Autor:
William C. Lamanna, Robert Ernst Mayer, Alfred Rupprechter, Michael Fuchs, Fabian Higel, Cornelius Fritsch, Cornelia Vogelsang, Andreas Seidl, Hansjoerg Toll, Martin Schiestl, Johann Holzmann
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
Abstract Etanercept is a TNFα receptor Fc fusion protein used for the treatment of rheumatic disease and psoriasis. Physicochemical and functional investigation of process fractions during development of the etanercept biosimilar GP2015 (Erelzi®) r
Externí odkaz:
https://doaj.org/article/c7209dcd6ffd42fea8b0b256f819198c
Autor:
Johann Holzmann, Antonio Z Politi, Kota Nagasaka, Merle Hantsche-Grininger, Nike Walther, Birgit Koch, Johannes Fuchs, Gerhard Dürnberger, Wen Tang, Rene Ladurner, Roman R Stocsits, Georg A Busslinger, Béla Novák, Karl Mechtler, Iain Finley Davidson, Jan Ellenberg, Jan-Michael Peters
Publikováno v:
eLife, Vol 8 (2019)
The organisation of mammalian genomes into loops and topologically associating domains (TADs) contributes to chromatin structure, gene expression and recombination. TADs and many loops are formed by cohesin and positioned by CTCF. In proliferating ce
Externí odkaz:
https://doaj.org/article/b4dd695cfba54d39a1aacd86fcfa079a
Autor:
Veronika Reisinger, Marius Segl, Wolfgang Esser-Skala, Therese Wohlschlager, Christian G. Huber, Johann Holzmann
Publikováno v:
Analytical and Bioanalytical Chemistry
Manufacturing of biopharmaceuticals involves recombinant protein expression in host cells followed by extensive purification of the target protein. Yet, host cell proteins (HCPs) may persist in the final drug product, potentially reducing its quality
Autor:
Monika Schweigler, Xinghua Guo, Andreas Seidl, Martin Schiestl, Johann Holzmann, Thomas Stangler, William C. Lamanna, Hillel P. Cohen
Publikováno v:
Expert Opinion on Biological Therapy. 18:369-379
Introduction: Biopharmaceuticals are large protein based drugs which are heterogeneous by nature due to post translational modifications resulting from cellular production, processing and storage. Changes in the abundance of different variants over t
Autor:
Bela Novak, Antonio Z. Politi, Iain F. Davidson, Jan-Michael Peters, Wen Tang, Johann Holzmann, Gerhard Dürnberger, Georg A. Busslinger, Birgit Koch, Jan Ellenberg, Kota Nagasaka, Rene Ladurner, Nike Walther, Merle Hantsche-Grininger, Johannes Fuchs, Karl Mechtler, Roman R. Stocsits
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b25d294a3a2b79852a7eb980c6a02964
https://doi.org/10.7554/elife.46269.033
https://doi.org/10.7554/elife.46269.033
Autor:
Jan Ellenberg, Jan-Michael Peters, Nike Walther, Wen Tang, Johann Holzmann, Antonio Z. Politi, Kota Nagasaka, Gerhard Dürnberger, Merle Hantsche-Grininger, Bela Novak, Iain F. Davidson, Birgit Koch, Karl Mechtler, Rene Ladurner, Roman R. Stocsits, Georg A. Busslinger, Johannes Fuchs
Publikováno v:
eLife
eLife, Vol 8 (2019)
eLife, Vol 8 (2019)
The organisation of mammalian genomes into loops and topologically associating domains (TADs) contributes to chromatin structure, gene expression and recombination. Loops and TADs are formed by cohesin and positioned by CTCF. In proliferating cells,
Autor:
Christian G. Huber, Johann Holzmann, Wolfgang Esser-Skala, Martin Samonig, Iris Wagner, Christof Regl, Therese Wohlschlager
Publikováno v:
mAbs
Monoclonal antibodies (mAbs) are widely applied as highly specific and efficient therapeutic agents for various medical conditions, including cancer, inflammatory and autoimmune diseases. As protein production in cellular systems inherently generates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59d77195ad8257d51f6244f15c74ba0c
https://eplus.uni-salzburg.at/doi/10.1080/19420862.2018.1563034
https://eplus.uni-salzburg.at/doi/10.1080/19420862.2018.1563034
Autor:
Elisa Vilardo, Christa Nachbagauer, Aurélie Buzet, Andreas Taschner, Johann Holzmann, Walter Rossmanith
Publikováno v:
Nucleic Acids Research
Transfer RNAs (tRNAs) reach their mature functional form through several steps of processing and modification. Some nucleotide modifications affect the proper folding of tRNAs, and they are crucial in case of the non-canonically structured animal mit
Autor:
William C. Lamanna, Andreas Seidl, Johann Holzmann, Hansjoerg Toll, Martin Hartinger, Anna Hausberger
Publikováno v:
BioDrugs. 30:233-242
Filgrastim is a recombinant, non-glycosylated form of human granulocyte colony-stimulating factor, used to stimulate leukocyte proliferation in patients suffering from neutropenia. Since the expiration of patents associated with Amgen’s filgrastim