Výsledky vyhledávání - "Johann H. Sattler"

Introducing an In Situ Capping Strategy in Systems Biocatalysis To Access 6-Aminohexanoic acid

Autor: Philip Engel, Francesco G. Mutti, John M. Woodley, Johann H. Sattler, Jan Pfeffer, Michael Fuchs, Barbara Grischek, Wolfgang Kroutil

Publikováno v: Angewandte Chemie International Edition. 53:14153-14157

The combination of two cofactor self-sufficient biocatalytic cascade modules allowed the successful transformation of cyclohexanol into the nylon-6 monomer 6-aminohexanoic acid at the expense of only oxygen and ammonia. A hitherto unprecedented carbo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f5f622e1e27443ff026d8ee5d1813d3
https://doi.org/10.1002/anie.201409227

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Deracemisierung durch simultane bio-oxidative Racematspaltung und Stereoinversion

Autor: Joerg H. Schrittwieser, Eva-Maria Fischereder, Nicholas J. Turner, Peter Macheroux, Wolfgang Kroutil, Elisabeth Fuchs, Bas Groenendaal, Diego Ghislieri, Barbara Grischek, Silvia Wallner, Johann H. Sattler, Verena Resch

Publikováno v: Angewandte Chemie. 126:3805-3809

Deracemisierung, also die Umwandlung eines Racemats in ein enantiomerenreines Produkt mit theoretisch 100 % Ausbeute und 100 % ee, stellt eine attraktive, aber auch anspruchsvolle Option fur die asymmetrische Synthese dar. Hier beschreiben wir ein ne

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https://doi.org/10.1002/ange.201400027

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Enzymatic asymmetric synthesis of the silodosin amine intermediate

Autor: Johann H. Sattler, Ferdinand Zepeck, Nina Richter, Wolfgang Kroutil, Judith E. Farnberger, Christine S. Fuchs, Robert C. Simon

Publikováno v: Tetrahedron: Asymmetry. 25:284-288

Various enantiocomplementary ω-transaminases (ωTAs) were investigated in kinetic resolution and asymmetric reductive amination reactions to prepare silodosin amine. Whilst the enzymatic kinetic resolution gave moderate to good results with respect

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https://doi.org/10.1016/j.tetasy.2013.12.012

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Deracemisation of benzylisoquinoline alkaloids employing monoamine oxidase variants

Autor: Verena Resch, Simon C. Willies, Bas Groenendaal, Barbara Grischek, Johann H. Sattler, Joerg H. Schrittwieser, Diego Ghislieri, Ian Rowles, Wolf-Dieter Lienhart, Nicholas J. Turner, Wolfgang Kroutil, Eva-Maria Fischereder

Publikováno v: Catal. Sci. Technol.. 4:3657-3664

Chemo-enzymatic deracemisation was applied to obtain the (S)-enantiomer of 1-benzylisoquinolines from the racemate in high isolated yield (up to 85%) and excellent optical purity (ee > 97%). The one-pot deracemisation protocol encompassed enantiosele

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https://doi.org/10.1039/c4cy00642a

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Asymmetric Amination of Tetralone and Chromanone Derivatives Employing ω-Transaminases

Autor: Wolfgang Kroutil, Tanja Knaus, Desiree Pressnitz, Johann H. Sattler, Francesco G. Mutti, Peter Macheroux, Christine S. Fuchs

Publikováno v: ACS Catalysis

Various (S)-selective and (R)-selective ω-transaminases were investigated for the amination of 1- and 2-tetralone and derivatives as well as of 3- and 4-chromanone. All ketones tested were aminated to give the corresponding enantiopure amines (ee >

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https://doi.org/10.1021/cs400002d

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Artificial Multi-Enzyme Networks for the Asymmetric Amination ofsec-Alcohols

Autor: Johann H. Sattler, Katharina Tauber, Thomas Dr. Haas, Wolfgang Kroutil, Dominik Koszelewski, Kurt Faber, Jan Pfeffer, Michael Fuchs, Julia Pitzer, Desiree Pressnitz

Publikováno v: Chemistry-A European Journal

Various artificial network designs that involve biocatalysts were tested for the asymmetric amination of sec-alcohols to the corresponding α-chiral primary amines. The artificial systems tested involved three to five redox enzymes and were exemplary

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Improved chemoenzymatic asymmetric synthesis of (S)-Rivastigmine

Autor: Johann H. Sattler, Mathias Pickl, Wilfried Banko, Wolfgang Kroutil, Dominik Koszelewski, Katharina Tauber, Kurt Faber, Michael Fuchs, Anja K. Holzer

Publikováno v: Tetrahedron. 68:7691-7694

(S)-Rivastigmine [(S)-1] was obtained via a four-step synthesis using an asymmetric enzymatic transamination protocol as the key step. An early introduction of the carbamate pharmacophore side chain avoided the use of protective group strategies and

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https://doi.org/10.1016/j.tet.2012.06.031

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