Výsledky vyhledávání - "Johann H, Sattler"

Introducing an In Situ Capping Strategy in Systems Biocatalysis To Access 6-Aminohexanoic acid

Autor: Philip Engel, Francesco G. Mutti, John M. Woodley, Johann H. Sattler, Jan Pfeffer, Michael Fuchs, Barbara Grischek, Wolfgang Kroutil

Publikováno v: Angewandte Chemie International Edition. 53:14153-14157

The combination of two cofactor self-sufficient biocatalytic cascade modules allowed the successful transformation of cyclohexanol into the nylon-6 monomer 6-aminohexanoic acid at the expense of only oxygen and ammonia. A hitherto unprecedented carbo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f5f622e1e27443ff026d8ee5d1813d3
https://doi.org/10.1002/anie.201409227

Zobrazit plný text záznamu

Deracemisierung durch simultane bio-oxidative Racematspaltung und Stereoinversion

Autor: Joerg H. Schrittwieser, Eva-Maria Fischereder, Nicholas J. Turner, Peter Macheroux, Wolfgang Kroutil, Elisabeth Fuchs, Bas Groenendaal, Diego Ghislieri, Barbara Grischek, Silvia Wallner, Johann H. Sattler, Verena Resch

Publikováno v: Angewandte Chemie. 126:3805-3809

Deracemisierung, also die Umwandlung eines Racemats in ein enantiomerenreines Produkt mit theoretisch 100 % Ausbeute und 100 % ee, stellt eine attraktive, aber auch anspruchsvolle Option fur die asymmetrische Synthese dar. Hier beschreiben wir ein ne

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::120d57b9a9692147f189759ed205ad18
https://doi.org/10.1002/ange.201400027

Zobrazit plný text záznamu

Plný text ve formátu HTML

Enzymatic asymmetric synthesis of the silodosin amine intermediate

Autor: Johann H. Sattler, Ferdinand Zepeck, Nina Richter, Wolfgang Kroutil, Judith E. Farnberger, Christine S. Fuchs, Robert C. Simon

Publikováno v: Tetrahedron: Asymmetry. 25:284-288

Various enantiocomplementary ω-transaminases (ωTAs) were investigated in kinetic resolution and asymmetric reductive amination reactions to prepare silodosin amine. Whilst the enzymatic kinetic resolution gave moderate to good results with respect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bbb5d7f485713fcb0c3bb5eab7c36d3c
https://doi.org/10.1016/j.tetasy.2013.12.012

Zobrazit plný text záznamu

Deracemisation of benzylisoquinoline alkaloids employing monoamine oxidase variants

Autor: Verena Resch, Simon C. Willies, Bas Groenendaal, Barbara Grischek, Johann H. Sattler, Joerg H. Schrittwieser, Diego Ghislieri, Ian Rowles, Wolf-Dieter Lienhart, Nicholas J. Turner, Wolfgang Kroutil, Eva-Maria Fischereder

Publikováno v: Catal. Sci. Technol.. 4:3657-3664

Chemo-enzymatic deracemisation was applied to obtain the (S)-enantiomer of 1-benzylisoquinolines from the racemate in high isolated yield (up to 85%) and excellent optical purity (ee > 97%). The one-pot deracemisation protocol encompassed enantiosele

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f8c166c256f956cd7de35eaac48988db
https://doi.org/10.1039/c4cy00642a

Zobrazit plný text záznamu

Asymmetric Amination of Tetralone and Chromanone Derivatives Employing ω-Transaminases

Autor: Wolfgang Kroutil, Tanja Knaus, Desiree Pressnitz, Johann H. Sattler, Francesco G. Mutti, Peter Macheroux, Christine S. Fuchs

Publikováno v: ACS Catalysis

Various (S)-selective and (R)-selective ω-transaminases were investigated for the amination of 1- and 2-tetralone and derivatives as well as of 3- and 4-chromanone. All ketones tested were aminated to give the corresponding enantiopure amines (ee >

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86aa04cdf8ca409b1f3d8df11651ba6c
https://doi.org/10.1021/cs400002d

Zobrazit plný text záznamu

Artificial Multi-Enzyme Networks for the Asymmetric Amination ofsec-Alcohols

Autor: Johann H. Sattler, Katharina Tauber, Thomas Dr. Haas, Wolfgang Kroutil, Dominik Koszelewski, Kurt Faber, Jan Pfeffer, Michael Fuchs, Julia Pitzer, Desiree Pressnitz

Publikováno v: Chemistry-A European Journal

Various artificial network designs that involve biocatalysts were tested for the asymmetric amination of sec-alcohols to the corresponding α-chiral primary amines. The artificial systems tested involved three to five redox enzymes and were exemplary

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9a88390a3fff50b5513d837bc82ba8b

Zobrazit plný text záznamu

Plný text ve formátu HTML

Improved chemoenzymatic asymmetric synthesis of (S)-Rivastigmine

Autor: Johann H. Sattler, Mathias Pickl, Wilfried Banko, Wolfgang Kroutil, Dominik Koszelewski, Katharina Tauber, Kurt Faber, Michael Fuchs, Anja K. Holzer

Publikováno v: Tetrahedron. 68:7691-7694

(S)-Rivastigmine [(S)-1] was obtained via a four-step synthesis using an asymmetric enzymatic transamination protocol as the key step. An early introduction of the carbamate pharmacophore side chain avoided the use of protective group strategies and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0b879914ee87df2c9a980f46e380adb7
https://doi.org/10.1016/j.tet.2012.06.031

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání