Movie S5 from Cytoplasmic Localization of Prostate-Specific Membrane Antigen Inhibitors May Confer Advantages for Targeted Cancer Therapies

Autor: Ann-Christin Eder, Stefan W. Hell, Klaus Kopka, Matthias Eder, Uwe Haberkorn, Philipp T. Meyer, Ulrike Bauder-Wüst, Martin Schäfer, Johann Engelhardt, Jessica Matthias

STED LNCaP PSMA-STAR 600 LysoTracker Green DND-26 and STED LNCaP PSMA-STAR 600 SiR-lysosome 5um

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::401a6d67d86151bf4c5b4c4b2d1c53cc
https://doi.org/10.1158/0008-5472.22430310.v1

Data from Cytoplasmic Localization of Prostate-Specific Membrane Antigen Inhibitors May Confer Advantages for Targeted Cancer Therapies

Autor: Ann-Christin Eder, Stefan W. Hell, Klaus Kopka, Matthias Eder, Uwe Haberkorn, Philipp T. Meyer, Ulrike Bauder-Wüst, Martin Schäfer, Johann Engelhardt, Jessica Matthias

Targeted imaging and therapy approaches based on novel prostate-specific membrane antigen (PSMA) inhibitors have fundamentally changed the treatment regimen of prostate cancer. However, the exact mechanism of PSMA inhibitor internalization has not ye

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5fb254899b8c5300ca67b4619a85d563
https://doi.org/10.1158/0008-5472.c.6513591.v1

MINFLUX dissects the unimpeded walking of kinesin-1

Autor: Jan O. Wolff, Lukas Scheiderer, Tobias Engelhardt, Johann Engelhardt, Jessica Matthias, Stefan W. Hell

Publikováno v: Science

We report on an interferometric MINFLUX microscope that records protein movements with down to 1.7 nm precision within less than 1 ms. While such spatio-temporal resolution has so far required linking a strongly scattering 30-500 nm diameter bead to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04e1a7347ca6365b2a29f82ef84b6f92
https://doi.org/10.1101/2022.07.25.501426

Fluorescent-protein stabilization and high-resolution imaging of cleared, intact mouse brains.

Autor: Martin K Schwarz, Annemarie Scherbarth, Rolf Sprengel, Johann Engelhardt, Patrick Theer, Guenter Giese

Publikováno v: PLoS ONE, Vol 10, Iss 5, p e0124650 (2015)

In order to observe and quantify long-range neuronal connections in intact mouse brain by light microscopy, it is first necessary to clear the brain, thus suppressing refractive-index variations. Here we describe a method that clears the brain and pr

Externí odkaz: https://doaj.org/article/02b22ab34ad042fea247e183048e19fb

Mouse Heterochromatin Adopts Digital Compaction States without Showing Hallmarks of HP1-Driven Liquid-Liquid Phase Separation

Autor: Ahmad Al Alwash, Caroline Bauer, Johann Engelhardt, Jana Tünnermann, Elisabeth Schweigert, Rifka Vlijm, Lukas Frank, Fabian Erdel, Christophe Normand, Klaus Yserentant, Anne Rademacher, Karsten Rippe, Robin Weinmann, Sabrina Schumacher, Dirk-Peter Herten, Johan Hummert

Publikováno v: Molecular Cell, 78(2), 236-249.e7. CELL PRESS
Molecular Cell
Molecular Cell, Elsevier, 2020, 78 (2), pp.236-249.e7. ⟨10.1016/j.molcel.2020.02.005⟩

The formation of silenced and condensed heterochromatin foci involves enrichment of heterochromatin protein 1 (HP1). HP1 can bridge chromatin segments and form liquid droplets, but the biophysical principles underlying heterochromatin compartmentaliz

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5d8e9e7ec73de04bbc961601f9473bf
https://research.rug.nl/en/publications/d8049ffa-ba8d-4a0f-8bf7-8ee9d40f3c77