Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Johann E. Kufs"'
Autor:
Slavica Janevska, Sophie Weiser, Ying Huang, Jun Lin, Sandra Hoefgen, Katarina Jojić, Amelia E. Barber, Tim Schäfer, Janis Fricke, Dirk Hoffmeister, Lars Regestein, Vito Valiante, Johann E. Kufs
Publikováno v:
Microbial Biotechnology, Vol 17, Iss 11, Pp n/a-n/a (2024)
Abstract The high therapeutic potential of psilocybin, a prodrug of the psychotropic psilocin, holds great promise for the treatment of mental disorders such as therapy‐refractory depression, alcohol use disorder and anorexia nervosa. Psilocybin ha
Externí odkaz:
https://doaj.org/article/53d44d76fc64408d9d6a7f5b39599526
Publikováno v:
mBio, Vol 15, Iss 6 (2024)
ABSTRACT Amoebae are environmental predators feeding on bacteria, fungi, and other eukaryotic microbes. Predatory interactions alter microbial communities and impose selective pressure toward phagocytic resistance or escape which may, in turn, foster
Externí odkaz:
https://doaj.org/article/fb0460f5674644b1bda92205b53df368
Publikováno v:
Microbial Cell Factories, Vol 21, Iss 1, Pp 1-10 (2022)
Abstract Background The availability of new biological platform organisms to get access to innovative products and processes is fundamental for the progress in biotechnology and bioeconomy. The amoeba Dictyostelium discoideum represents a novel host
Externí odkaz:
https://doaj.org/article/961d335ecf9d4f7a8669ac1f2ea71b74
Autor:
Alexander U. Bissell, Julia Rautschek, Sandra Hoefgen, Luka Raguž, Derek J. Mattern, Nauman Saeed, Slavica Janevska, Katarina Jojić, Ying Huang, Johann E. Kufs, Barbara Herboeck, Huijuan Guo, Falk Hillmann, Christine Beemelmanns, Vito Valiante
Publikováno v:
ACS Chem Biol
Sphingofungins belong to a group of structurally related sphingolipid inhibitors produced by fungi, which specifically inhibit serine palmitoyl transferases, enzymes catalyzing the initial step during sphingolipid biosynthesis. Sphingolipids are inte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94e19c2f19eac7bad1e98affc3aca96a
https://doi.org/10.1021/acschembio.1c00839
https://doi.org/10.1021/acschembio.1c00839
Autor:
Christin Reimer, Johann E. Kufs, Julia Rautschek, Lars Regestein, Vito Valiante, Falk Hillmann
Publikováno v:
Nature Biotechnology. 40:751-758
Aromatic polyketides are natural polyphenolic compounds with a broad spectrum of pharmacological activities. Production of those metabolites in the model organisms Escherichia coli and Saccharomyces cerevisiae has been limited by the extensive cellul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0b1cf1bbcc9d70d3d1016f825ef2cce
https://doi.org/10.1038/s41587-021-01143-8
https://doi.org/10.1038/s41587-021-01143-8
Autor:
Markus Günther, Christin Reimer, Rosa Herbst, Johann E. Kufs, Julia Rautschek, Nico Ueberschaar, Shuaibing Zhang, Gundela Peschel, Lisa Reimer, Lars Regestein, Vito Valiante, Falk Hillmann, Pierre Stallforth
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Low-molecular-weight natural products from microbes are indispensable in the development of potent drugs. However, their biological roles within an ecological context often remain elusive. Here, we shed light on natural products from eukaryotic micro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5890e5b53d770eca49eb00e0a4843dfb
https://doi.org/10.1073/pnas.2116122119
https://doi.org/10.1073/pnas.2116122119
Publikováno v:
Current Opinion in Biotechnology. 77:102766
The identification of novel platform organisms for the production and discovery of small molecules is of high interest for the pharmaceutical industry. In particular, the structural complexity of most natural products with therapeutic potential restr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4feb2e55f023ca78767770ad4c4dd6aa
https://doi.org/10.1016/j.copbio.2022.102766
https://doi.org/10.1016/j.copbio.2022.102766
Autor:
Vito Valiante, Sandra Hoefgen, Daniel F.O. Braga, Miriam A. Rosenbaum, Johann E Kufs, Julia Rautschek, Julian Thiele, Alexander U Bissell, Lars Regestein, Jonas Fiedler, Carola Graf
Publikováno v:
ACS synthetic biology. 9(7)
Combinatorial biosynthesis has great potential for designing synthetic circuits and amplifying the production of new active compounds. Studies on multienzyme cascades are extremely useful for improving our knowledge on enzymatic catalysis. In particu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07e3db721096b8fd98dc524b5fee1ee8
https://pubmed.ncbi.nlm.nih.gov/32525654
https://pubmed.ncbi.nlm.nih.gov/32525654
Autor:
Derek J. Mattern, Axel A. Brakhage, Sandra Hoefgen, Maria C. Stroe, Johann E. Kufs, Janis Fricke, Peter Hortschansky, Vito Valiante, Jun Lin, Dirk Hoffmeister
Publikováno v:
Metabolic Engineering. 48:44-51
Heterologous expression of multi-gene biosynthetic pathways in eukaryotic hosts is limited by highly regulated individual monocistrons. Dissimilar to prokaryotes, each eukaryotic gene is strictly controlled by its own regulatory elements, such as pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7702e41ce6e128f56cea5d2ece2f11c6
https://doi.org/10.1016/j.ymben.2018.05.014
https://doi.org/10.1016/j.ymben.2018.05.014