Zobrazeno 1 - 10
of 393
pro vyhledávání: '"Johann E Gudjonsson"'
Autor:
Lam C Tsoi, Allison C Billi, Rachael Wasikowski, Johann E Gudjonsson, Feiyang Ma, Olesya Plazyo, Mehrnaz Gharaee-Kermani, Amy Hurst, Craig J Dobry, J Michelle Kahlenberg
Publikováno v:
Lupus Science and Medicine, Vol 8, Iss Suppl 2 (2021)
Externí odkaz:
https://doaj.org/article/bb91a219ba984f30aa738dc5923f089d
Autor:
Sirisha Sirobhushanam, Allison C Billi, Celine C Berthier, Lam C Tsoi, Johann E Gudjonsson, J Michelle Kahlenberg
Publikováno v:
Journal of Clinical and Translational Science, Vol 4, Pp 131-131 (2020)
OBJECTIVES/GOALS: Lupus lesional skin has elevated interferon expression, is highly colonized with Staphylococcus aureus (50%) and has no FDA-approved treatment options. We decided to investigate the effect of topical antibiotics on lupus lesional sk
Externí odkaz:
https://doaj.org/article/50425e7a9c0449e1ba9bb1ccee1b8251
Autor:
Rachel Herndon Klein, Ziguang Lin, Amelia Soto Hopkin, William Gordon, Lam C Tsoi, Yun Liang, Johann E Gudjonsson, Bogi Andersen
Publikováno v:
PLoS Genetics, Vol 13, Iss 4, p e1006745 (2017)
Transcription factor binding, chromatin modifications and large scale chromatin re-organization underlie progressive, irreversible cell lineage commitments and differentiation. We know little, however, about chromatin changes as cells enter transient
Externí odkaz:
https://doaj.org/article/012d7b192ad54856915a7da3bbff9844
Autor:
Junyan Duan, Michelle N. Ngo, Satya Swaroop Karri, Lam C. Tsoi, Johann E. Gudjonsson, Babak Shahbaba, John Lowengrub, Bogi Andersen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract As the circadian clock regulates fundamental biological processes, disrupted clocks are often observed in patients and diseased tissues. Determining the circadian time of the patient or the tissue of focus is essential in circadian medicine
Externí odkaz:
https://doaj.org/article/4081073e60234614bf817f5fce0ddaca
Autor:
William R Swindell, Mrinal K Sarkar, Philip E Stuart, John J Voorhees, James T Elder, Andrew Johnston, Johann E Gudjonsson
Publikováno v:
Clinical and Translational Medicine, Vol 4, Iss 1, Pp n/a-n/a (2015)
Abstract BackgroundPsoriasis is a cytokine‐mediated skin disease that can be treated effectively with immunosuppressive biologic agents. These medications, however, are not equally effective in all patients and are poorly suited for treating mild p
Externí odkaz:
https://doaj.org/article/701228f45ce24c008a69346110a2e7f4
Autor:
Evgeniya Petrova, Jesús María López-Gay, Matthias Fahrner, Florent Leturcq, Jean-Pierre de Villartay, Claire Barbieux, Patrick Gonschorek, Lam C. Tsoi, Johann E. Gudjonsson, Oliver Schilling, Alain Hovnanian
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-24 (2024)
Abstract Netherton syndrome (NS) is a rare skin disease caused by loss-of-function mutations in the serine peptidase inhibitor Kazal type 5 (SPINK5) gene. Disease severity and the lack of efficacious treatments call for a better understanding of NS m
Externí odkaz:
https://doaj.org/article/a4b9cbf4d219401da0ec2c2e31fec3de
Autor:
Rachana Haliyur, MD, PhD, David H. Parkinson, MS, Feiyang Ma, PhD, Jing Xu, PhD, Qiang Li, MD, PhD, Yuanhao Huang, Lam C. Tsoi, PhD, Rachael Bogle, MS, Jie Liu, PhD, Johann E. Gudjonsson, MD, Rajesh C. Rao, MD
Publikováno v:
Ophthalmology Science, Vol 4, Iss 6, Pp 100539- (2024)
Purpose: Current therapies for proliferative diabetic retinopathy (PDR) do not specifically target VEGF-independent, cell-type–specific processes that lead to vision loss, such as inflammatory pathways. This study aimed to identify targetable cell
Externí odkaz:
https://doaj.org/article/f4ad998418104f48bf24a27ebc226ad3
Autor:
Feiyang Ma, Pei-Suen Tsou, Mehrnaz Gharaee-Kermani, Olesya Plazyo, Xianying Xing, Joseph Kirma, Rachael Wasikowski, Grace A. Hile, Paul W. Harms, Yanyun Jiang, Enze Xing, Mio Nakamura, Danielle Ochocki, William D. Brodie, Shiv Pillai, Emanual Maverakis, Matteo Pellegrini, Robert L. Modlin, John Varga, Lam C. Tsoi, Robert Lafyatis, J. Michelle Kahlenberg, Allison C. Billi, Dinesh Khanna, Johann E. Gudjonsson
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Systemic sclerosis (SSc) is a devastating autoimmune disease characterized by excessive production and accumulation of extracellular matrix, leading to fibrosis of skin and other internal organs. However, the main cellular participants in SS
Externí odkaz:
https://doaj.org/article/3b5a5e9a32fc4187b638ed4405b8d22c
Autor:
William R Swindell, Andrew Johnston, Xianying Xing, John J Voorhees, James T Elder, Johann E Gudjonsson
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e79253 (2013)
Whole-genome expression profiling has been used to characterize molecular-level differences between psoriasis lesions and normal skin. Pathway analysis, however, is complicated by the fact that expression profiles have been derived from bulk skin bio
Externí odkaz:
https://doaj.org/article/153bf196dbb6472eaf1289346efeebb2
Autor:
William R Swindell, Xianying Xing, Philip E Stuart, Cynthia S Chen, Abhishek Aphale, Rajan P Nair, John J Voorhees, James T Elder, Andrew Johnston, Johann E Gudjonsson
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e34594 (2012)
The clinical features of psoriasis, characterized by sharply demarcated scaly erythematous plaques, are typically so distinctive that a diagnosis can easily be made on these grounds alone. However, there is great variability in treatment response bet
Externí odkaz:
https://doaj.org/article/c9c6ca80713f49babc4b79fdb00daf63