Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Johann Chan"'
Autor:
Daniel F. A. R. Dourado, Balamurali Kannan, Darren Gray, Johann Chan, Michael J. Geier, Aliaksei Pukin, Stefan Mix, Mark E. Scott, Luke D. Humphreys, Xiaotian Wang, Gareth Brown
Publikováno v:
Organic Process Research & Development. 26:849-858
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ee50c6dbd1532716851cf61efb2ee47
https://doi.org/10.1021/acs.oprd.1c00250
https://doi.org/10.1021/acs.oprd.1c00250
Autor:
Jack Hung-Chang Liu, Petar A. Duspara, Chris Walpole, Johann Chan, Ernest E. Lee, Robert A. Batey, Hua Yang, Craig M. Bryant, Ziping Liu, Edward Roberts, David A. Powell
Publikováno v:
Tetrahedron Letters. 53:2971-2975
The fluorination of ketones, ketals, and enamides has been achieved using the electrophilic fluorinating reagent Selectfluor™ (F-TEDA-BF 4 ). For the reactions of ketones and ketals the use of sulfuric acid (0.1 equiv) as an additive was found to f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa15d36345dd7e898b3aa57afb3d2a72
https://doi.org/10.1016/j.tetlet.2012.03.074
https://doi.org/10.1016/j.tetlet.2012.03.074
Publikováno v:
Tetrahedron Letters. 53:3237-3241
A highly efficient and regioselective Friedlander reaction of unsymmetrical 1,3-diketones with 2-aminoaryl aldehydes (ketones) is described. The methodology leads to the synthesis of a broad scope of substituted quinolines in high yield and excellent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::73517d88f12350ac6576ac81f07a8934
https://doi.org/10.1016/j.tetlet.2012.04.038
https://doi.org/10.1016/j.tetlet.2012.04.038
Autor:
Jason Duquette, Johann Chan, Darin J. Gustin, An-Rong Li, Xiaoqi Chen, Jeff Deignan, Julio C. Medina, Xiaohui Du, George Tonn, Tim Sullivan, Jeffrey T. Mihalic, Bryan Lemon, Kirk Henne, Shichang Miao, Michael Johnson, Zice Fu, Ji Ma, Tassie L. Collins
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:357-362
The optimization of a series of 8-aza-quinazolinone analogs for antagonist activity against the CXCR3 receptor is reported. Compounds were optimized to avoid the formation of active metabolites and time-dependent-inhibitors of CYP3A4. In addition, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::339aed731e6cb3461777050b365762b1
https://doi.org/10.1016/j.bmcl.2011.10.120
https://doi.org/10.1016/j.bmcl.2011.10.120
Autor:
Vivian K. Robertson, Henry Morrison, Johann Chan, Brenda J. Burke, Jonan Jona, Jan Fang, Dennis Lei, Anu Gore, Karthik Nagapudi
Publikováno v:
Organic Process Research & Development. 15:1336-1343
AMG 369 (1), a novel S1P1 agonist, was selected for clinical development for the treatment of multiple sclerosis. Form B of the zwitterionic molecule was initially identified as a potential development form. However, because of the instability of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c173b5f0d1e13c17960199fe7b748839
https://doi.org/10.1021/op200192n
https://doi.org/10.1021/op200192n
Publikováno v:
Synlett. 2011:1419-1422
An efficient and mild copper-catalyzed ether formation from aryl halides and aliphatic alcohols has been developed. The key to the successful coupling is the use of lithium alkoxide, directly or in situ generated by lithium tert-butoxide, and the cor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::068eb6297d1829bdb118da5e61dc0484
https://doi.org/10.1055/s-0030-1260761
https://doi.org/10.1055/s-0030-1260761
Autor:
Jerry A. Murry, Brenda J. Burke, Matthew M. Bio, Margaret M. Faul, Karl B. Hansen, Evan DiVirgilio, Johann Chan, Kyle D. Baucom
Publikováno v:
The Journal of Organic Chemistry. 76:1767-1774
Two new, reliable syntheses of a pyrido[2,3-d]-pyrimidine inhibitor of the CXCR3 receptor are described. A nine-step synthesis of the CXCR3 inhibitor (1) from 2-aminonicotinic acid was demonstrated on a multikilogram scale and incorporates a classic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c87e5f31297cd989041fb52b9baa24bc
https://doi.org/10.1021/jo102399a
https://doi.org/10.1021/jo102399a
Publikováno v:
Synlett. 2009:3139-3142
O-Ethyl thioformate has been synthesized from triethylorthoformate and hydrogen sulfide gas using a Bronstead acid catalyst. The product can be isolated as a neat liquid in 83% overall yield. Both the crude and purified thiolate can be used to thiofo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c67c01bef5b0341d6b517e3af7a0a38
https://doi.org/10.1055/s-0029-1218343
https://doi.org/10.1055/s-0029-1218343
Publikováno v:
Synthesis. 2007:3678-3682
Substituted pyrido[2,3-d]pyrimidines are synthesized in good to excellent yields by treatment of various 2-aminonicotin-amides with triethyl orthopropionate or triethyl orthoacetate in the presence of acetic acid.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d707b6f8f88f7bdf4a15ebc88f89d96
https://doi.org/10.1055/s-2007-990878
https://doi.org/10.1055/s-2007-990878
Publikováno v:
Tetrahedron Letters. 48:4825-4829
Several synthetic strategies to diamines 1 – 3 are described. The optimum approach via opening of aziridine afforded 1 – 3 in 29–60% yield over 3–5 steps. A study on formation of the benzylic stereocenter using Toste’s rhenium-catalyzed asy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6e5e70a3bd6d8d1d64d09cdf18401ce9
https://doi.org/10.1016/j.tetlet.2007.05.073
https://doi.org/10.1016/j.tetlet.2007.05.073