Molecular recognition of a membrane-anchored HIV-1 pan-neutralizing epitope

Autor: Johana Torralba, Igor de la Arada, Angélica Partida-Hanon, Edurne Rujas, Madalen Arribas, Sara Insausti, Claire Valotteau, Javier Valle, David Andreu, José M. M. Caaveiro, María Angeles Jiménez, Beatriz Apellániz, Lorena Redondo-Morata, José L. Nieva

Publikováno v: Communications Biology, Vol 5, Iss 1, Pp 1-14 (2022)

The molecular recognition of the carboxy-terminal section of the membrane-proximal external region (C-MPER) of the HIV-1 envelope glycoprotein in membrane mimetics is characterised to help shape continued development of more efficient and stable anti

Externí odkaz: https://doaj.org/article/45ecf657a3324b21b3025d23f9342963

Structure of HIV-1 gp41 with its membrane anchors targeted by neutralizing antibodies

Autor: Christophe Caillat, Delphine Guilligay, Johana Torralba, Nikolas Friedrich, Jose L Nieva, Alexandra Trkola, Christophe J Chipot, François L Dehez, Winfried Weissenhorn

Publikováno v: eLife, Vol 10 (2021)

The HIV-1 gp120/gp41 trimer undergoes a series of conformational changes in order to catalyze gp41-induced fusion of viral and cellular membranes. Here, we present the crystal structure of gp41 locked in a fusion intermediate state by an MPER-specifi

Externí odkaz: https://doaj.org/article/c1f8eb01d322414cb7d10e348e2d38dc

Functional Delineation of a Protein–Membrane Interaction Hotspot Site on the HIV-1 Neutralizing Antibody 10E8

Autor: Sara Insausti, Miguel Garcia-Porras, Johana Torralba, Izaskun Morillo, Ander Ramos-Caballero, Igor de la Arada, Beatriz Apellaniz, Jose M. M. Caaveiro, Pablo Carravilla, Christian Eggeling, Edurne Rujas, Jose L. Nieva

Publikováno v: International Journal of Molecular Sciences
Addi. Archivo Digital para la Docencia y la Investigación
instname
International Journal of Molecular Sciences; Volume 23; Issue 18; Pages: 10767

Antibody engagement with the membrane-proximal external region (MPER) of the envelope glycoprotein (Env) of HIV-1 constitutes a distinctive molecular recognition phenomenon, the full appreciation of which is crucial for understanding the mechanisms t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c3e062fad316f3395ede6e8e6582388

Conformational Plasticity Underlies Membrane Fusion Induced by an HIV Sequence Juxtaposed to the Lipid Envelope

Autor: José L. Nieva, Beatriz Apellaniz, Adai Colom, Igor de la Arada, Igor Tascón, José Luis R. Arrondo, Iban Ubarretxena-Belandia, Johana Torralba

Publikováno v: Addi. Archivo Digital para la Docencia y la Investigación
instname
Scientific Reports
Addi: Archivo Digital para la Docencia y la Investigación
Universidad del País Vasco
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)

Envelope glycoproteins from genetically-divergent virus families comprise fusion peptides (FPs) that have been posited to insert and perturb the membranes of target cells upon activation of the virus-cell fusion reaction. Conserved sequences rich in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c70637740b00901a49f8f672503f4327
http://hdl.handle.net/10810/50573

Antibody-epitope interactions mediated by lipid membranes in HIV: a study using FCS and single molecule tracking

Autor: Arturo G. Vesga, Cintia Vequi-Suplicy, Johana Torralba, Miguel Garcia-Porras, Pablo Carravilla, Jose L. Nieva, Jose Requejo-Isidro

Publikováno v: Biophysical Journal. 121:405a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8be5d33e1c3e6fbaeb1ca10566dc6891
https://doi.org/10.1016/j.bpj.2021.11.746