Zobrazeno 1 - 10 of 33 pro vyhledávání: '"Johan. G. C. van Hasselt"'
1
Akademický článek
Evaluation of a Cardiovascular Systems Model for Design and Analysis of Hemodynamic Safety Studies
Autor: Yu Fu, Nelleke Snelder, Tingjie Guo, Piet H. van der Graaf, Johan. G. C. van Hasselt
Publikováno v: Pharmaceutics, Vol 15, Iss 4, p 1175 (2023)
Early prediction, quantification and translation of cardiovascular hemodynamic drug effects is essential in pre-clinical drug development. In this study, a novel hemodynamic cardiovascular systems (CVS) model was developed to support these goals. The
Externí odkaz: https://doaj.org/article/cc5700369e59410fb74eaf1d2540d02e
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2
Akademický článek
Anti-cancer treatment schedule optimization based on tumor dynamics modelling incorporating evolving resistance
Autor: Anyue Yin, Johan G. C. van Hasselt, Henk-Jan Guchelaar, Lena E. Friberg, Dirk Jan A. R. Moes
Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Quantitative characterization of evolving tumor resistance under targeted treatment could help identify novel treatment schedules, which may improve the outcome of anti-cancer treatment. In this study, a mathematical model which considers va
Externí odkaz: https://doaj.org/article/1ee39881ae464dc7bfd80c8292074cc0
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4
Modelling inflammatory biomarker dynamics in a human lipopolysaccharide (LPS) challenge study using delay differential equations
Autor: Feiyan Liu, Linda B. S. Aulin, Tingjie Guo, Elke H. J. Krekels, Matthijs Moerland, Piet H. van der Graaf, Johan G. C. van Hasselt
Publikováno v: British Journal of Clinical Pharmacology, 88(12), 5420-5427. WILEY
Clinical studies in healthy volunteers challenged with lipopolysaccharide (LPS), a constituent of the cell wall of Gram-negative bacteria, represent a key model to characterize the Toll-like receptor 4 (TLR4)-mediated inflammatory response. Here, we
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::876f10c699b57e7f3bf4c27b458a72f5
https://doi.org/10.1111/bcp.15476
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5
Nonlinear blood-brain barrier transport and dosing strategies influence receptor occupancy ratios of morphine and its metabolites in pain matrix
Autor: Divakar Budda, Berfin Gülave, Johan G. C. van Hasselt, Elizabeth De Lange
Background & purpose Morphine is important for treatment of acute and chronic pain. However, there is high interpatient variability and often inadequate pain relief and adverse effects. To better understand variability in the dose effect relationship
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a32c97265bee61bd221a32e71142d212
https://doi.org/10.22541/au.168551715.56337335/v1
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6
Akademický článek
Mechanistic Systems Modeling to Improve Understanding and Prediction of Cardiotoxicity Caused by Targeted Cancer Therapeutics
Autor: Jaehee V. Shim, Bryan Chun, Johan G. C. van Hasselt, Marc R. Birtwistle, Jeffrey J. Saucerman, Eric A. Sobie
Publikováno v: Frontiers in Physiology, Vol 8 (2017)
Tyrosine kinase inhibitors (TKIs) are highly potent cancer therapeutics that have been linked with serious cardiotoxicity, including left ventricular dysfunction, heart failure, and QT prolongation. TKI-induced cardiotoxicity is thought to result fro
Externí odkaz: https://doaj.org/article/019bbcf38428463cbc966650fe5fb2dc
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7
A system pharmacology Boolean network model for the TLR4-mediated inflammatory response in early sepsis
Autor: Feiyan Liu, Linda B. S. Aulin, Sebastiaan S. A. Kossen, Julius Cathalina, Marlotte Bremmer, Amanda C. Foks, Piet H. van der Graaf, Matthijs Moerland, Johan G. C. van Hasselt
Publikováno v: Journal of Pharmacokinetics and Pharmacodynamics, 49(6), 645-655
Sepsis is a life-threatening condition driven by the dysregulation of the host immune response to an infection. The complex and interacting mechanisms underlying sepsis remain not fully understood. By integrating prior knowledge from literature using
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9089e834131675be66c066a2367c569e
https://pubmed.ncbi.nlm.nih.gov/36261775
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8
Pooled Population Pharmacokinetic Analysis for Exploring Ciprofloxacin Pharmacokinetic Variability in Intensive Care Patients
Autor: Tingjie, Guo, Alan, Abdulla, Birgit C P, Koch, Johan G C, van Hasselt, Henrik, Endeman, Jeroen A, Schouten, Paul W G, Elbers, Roger J M, Brüggemann, Reinier M, van Hest, Jaap, Ten Oever
Publikováno v: Clinical pharmacokinetics. 61(6)
Previous pharmacokinetic (PK) studies of ciprofloxacin in intensive care (ICU) patients have shown large differences in estimated PK parameters, suggesting that further investigation is needed for this population. Hence, we performed a pooled populat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0df40be8f499763987e51af0a556bb00
https://pubmed.ncbi.nlm.nih.gov/35262847
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9
Zebrafish larvae as experimental model to expedite the search for new biomarkers and treatments for neonatal sepsis
Autor: Sinno H.P. Simons, H. Rob Taal, C. A. J. Knibbe, Fleur M Keij, Bjørn E. V. Koch, Irwin K M Reiss, Fernando Lozano Vigario, Herman P. Spaink, Johan G. C. van Hasselt, Elke H. J. Krekels
Publikováno v: Journal of Clinical and Translational Science, 5(1)
Journal of Clinical and Translational Science
Neonatal sepsis is a major cause of death and disability in newborns. Commonly used biomarkers for diagnosis and evaluation of treatment response lack sufficient sensitivity or specificity. Additionally, new targets to treat the dysregulated immune r
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7516b79374815d4adb61d220426c7837
https://doi.org/10.1017/cts.2021.803
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10
Why we should sample sparsely and aim for a higher target: Lessons from model-based therapeutic drug monitoring of vancomycin in intensive care patients
Autor: Ron A. A. Mathôt, Reinier M. van Hest, Armand R. J. Girbes, Rob J. Bosman, Johan G. C. van Hasselt, Lucas M. Fleuren, Luca F. Roggeveen, Peter H. J. van der Voort, Tingjie Guo, Paul W. G. Elbers
Publikováno v: Guo, T, van Hest, R M, Fleuren, L M, Roggeveen, L F, Bosman, R J, van der Voort, P H J, Girbes, A R J, Mathot, R A A, van Hasselt, J G C & Elbers, P W G 2021, ' Why we should sample sparsely and aim for a higher target: Lessons from model-based therapeutic drug monitoring of vancomycin in intensive care patients ', British Journal of Clinical Pharmacology, vol. 87, no. 3, pp. 1234-1242 . https://doi.org/10.1111/bcp.14498
British journal of clinical pharmacology, 87(3), 1234-1242. Wiley-Blackwell
British Journal of Clinical Pharmacology, 87(3), 1234-1242. WILEY
British Journal of Clinical Pharmacology, 87(3), 1234-1242. Wiley-Blackwell
Aims To explore the optimal data sampling scheme and the pharmacokinetic (PK) target exposure on which dose computation is based in the model-based therapeutic drug monitoring (TDM) practice of vancomycin in intensive care (ICU) patients. Methods We
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c8d8c522974b4522c3281dd3e510423
https://research.vumc.nl/en/publications/e1ce522f-1646-4d31-a6b1-2e3ca7428784
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