Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Johan Weigelt"'
Autor:
Johan Weigelt, Anna Linusson, Tobias Karlberg, Urszula Uciechowska, Herwig Schüler, C. David Andersson, Mikael Elofsson, Anders E. G. Lindgren, T. Ekblad, Ann-Gerd Thorsell, Sara Spjut, Pernilla Wittung-Stafshede, Moritz S. Niemiec
Publikováno v:
Journal of Medicinal Chemistry. 55:7706-7718
The diphtheria toxin-like ADP-ribosyltransferases (ARTDs) are an enzyme family that catalyzes the transfer of ADP-ribose units onto substrate proteins by using nicotinamide adenine dinucleotide (NAD(+)) as a cosubstrate. They have a documented role i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45d9d3b12591daa0208e59e92f9a9387
https://doi.org/10.1021/jm300746d
https://doi.org/10.1021/jm300746d
Autor:
Agneta Tjernberg, Johan Weigelt, Johan Schultz, Stephen James, Kurt Benkestock, Styrbjörn Byström, Dan Hallén
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:891-895
The inhibitory effect on PTP1B caused by the addition of pyridazine analogues has been investigated. Biophysical techniques, that is, mass spectrometry (MS), nuclear magnetic resonance (NMR), and isothermal titration calorimetry (ITC) were used for t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd45db5c29530619c882d705259aa50b
https://doi.org/10.1016/j.bmcl.2003.12.014
https://doi.org/10.1016/j.bmcl.2003.12.014
Publikováno v:
Drug Discovery Today. 7:471-478
Structure-based screening represents an integrated approach for the identification and optimization of hits by the combined use of nuclear magnetic resonance (NMR) spectroscopy, homology modeling and X-ray crystallography. A general feature of the me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a80e679a15e5f77c7c0614158ed2a0d2
https://doi.org/10.1016/s1359-6446(02)02233-x
https://doi.org/10.1016/s1359-6446(02)02233-x
Autor:
Gottfried Otting, Mária Trexler, Johan Weigelt, László Bányai, Edvards Liepinsh, László Patthy, Andrei Kaikkonen
Publikováno v:
The EMBO Journal. 20:5347-5353
The LCCL domain is a recently discovered, conserved protein module named after its presence in Limulus factor C, cochlear protein Coch-5b2 and late gestation lung protein Lgl1. The LCCL domain plays a key role in the autosomal dominant human deafness
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a237cadb6fee20ab2fa2acd0c823ebb8
https://doi.org/10.1093/emboj/20.19.5347
https://doi.org/10.1093/emboj/20.19.5347
Publikováno v:
Structure. 7:681-690
Background: DnaB is the primary replicative helicase in Escherichia coli . Native DnaB is a hexamer of identical subunits, each consisting of a larger C-terminal domain and a smaller N-terminal domain. Electron-microscopy data show hexamers with C 6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8152cfb22232690c8d1bde1d641c35b
https://doi.org/10.1016/s0969-2126(99)80089-6
https://doi.org/10.1016/s0969-2126(99)80089-6
Autor:
Maria Dolores Herman, Masoud Vedadi, Jinrong Min, Slav Dimov, Hui Ouyang, Ida Johansson, Aiping Dong, Haizhong Zhu, Rosa Di Leo, Tatiana Skarina, Susanne Flodin, Alexei Savchenko, Ting Xiao, Changsoo Chang, Raymond Hui, Aled M. Edwards, Hee-Won Park, Masato Akutsu, George V. Avvakumov, Elena Evdokimova, Martin Welin, P. Nordlund, Maksymilian Chruszcz, Natalie R Klostermann, Yufeng Tong, Cheryl H. Arrowsmith, Ekaterina V. Filippova, Wolfram Tempel, Lars Göran Dahlgren, Andrzej Joachimiak, Marianne Cuff, Ludmila Dombrovski, Qiuni Que, Olga Egorova, Tomas Nyman, Xiaohui Xu, Jennifer L. Guthrie, Alexander F. Yakunin, Rongguang Zhang, Adelinda Yee, Alexandr Ignatchenko, Jun Gu, John R. Walker, Johan Weigelt, Hong Zeng, Yang Shen, Wael M. Rabeh, Sirano Dhe-Paganon, Kemin Tan, Yongson Liu, Alexey Bochkarev, Wladek Minor, Deepthi Sukumard, Lionel Tresagues, Hong Wu, Youngchang Kim, Hong Zheng, Bum Soo Hong, Martina Nilsson, Marcin Cymborowski, Chao Qi, P.J. Finerty, Veronica Yim, Martin Hammerström, Limin Shen, Yuri Korniyenko, Lyudmila Nedyalkova, A. Flores, Susanne Gräslund
Publikováno v:
Nature Methods. 4:1019-1021
We tested the general applicability of in situ proteolysis to form protein crystals suitable for structure determination by adding a protease (chymotrypsin or trypsin) digestion step to crystallization trials of 55 bacterial and 14 human proteins tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d384f298d521962cc871f139ce3a129a
https://doi.org/10.1038/nmeth1118
https://doi.org/10.1038/nmeth1118
Publikováno v:
Journal of Biomolecular NMR. 12:435-441
Novel α/β-half-filter elements are proposed for the separation of the high-field and low-field component of 1 J HC and 1 J HN splittings into different subspectra. The α/β-half-filter elements are of the same duration as the S3CT pulse sequence e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9850c3464379ec5b7596ae514e7aed4c
https://doi.org/10.1023/a:1008239027287
https://doi.org/10.1023/a:1008239027287
Autor:
Caroline S. Miles, Nicholas E. Dixon, Gottfried Otting, N. Patrick J. Stamford, Nada Dammerova, Johan Weigelt
Publikováno v:
Biochemical and Biophysical Research Communications. 231:126-130
Two separate N-terminal fragments of the 470-amino-acid Escherichia coli DnaB helicase, comprising residues 1-142 and 1-161, were expressed in E. coli. The proteins were extracted in a soluble fraction, purified, and characterised physically. In cont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10012530b1b183a4f0ee0db2a39bc9ad
https://doi.org/10.1006/bbrc.1997.6059
https://doi.org/10.1006/bbrc.1997.6059
Autor:
Tobias Karlberg, T. Ekblad, Sara Spjut, Mikael Elofsson, Ton Tong Nhan, Ann-Gerd Thorsell, Anders E. G. Lindgren, Herwig Schüler, Victor Hellsten, Johan Weigelt, Anna Linusson, C. David Andersson
Publikováno v:
Journal of medicinal chemistry. 56(23)
The racemic 3-(4-oxo-3,4-dihydroquinazolin-2-yl)-N-[1-(pyridin-2-yl)ethyl]propanamide, 1, has previously been identified as a potent but unselective inhibitor of diphtheria toxin-like ADP-ribosyltransferase 3 (ARTD3). Herein we describe synthesis and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f79356d99b7fd9ab888a1f4ea089eb61
https://pubmed.ncbi.nlm.nih.gov/24188023
https://pubmed.ncbi.nlm.nih.gov/24188023
Autor:
Sara Spjut, Johan Weigelt, Anna Linusson, Michael O. Hottiger, T. Ekblad, Herwig Schüler, A.F. Pinto, Anders E. G. Lindgren, Mareike Hesse, C.D. Andersson, Tobias Karlberg, Mikael Elofsson, Ann-Gerd Thorsell
Publikováno v:
ACS chemical biology
Inhibiting ADP-ribosyl transferases with PARP-inhibitors is considered a promising strategy for the treatment of many cancers and ischemia, but most of the cellular targets are poorly characterized. Here, we describe an inhibitor of ADP-ribosyltransf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4c6c24aababd8021f6ab74c119ea533
https://www.zora.uzh.ch/id/eprint/88986/
https://www.zora.uzh.ch/id/eprint/88986/
