Inhibition of Rho - ROCK signaling induces apoptotic and non-apoptotic PS exposure in cardiomyocytes via inhibition of flippase

Autor: Walter Paulus, Hans W.M. Niessen, Alice Muller, Victor W.M. van Hinsbergh, Arthur J. Verhoeven, C. Erik Hack, Paul A.J. Krijnen, Johan W. Molling, Jessica A. Sipkens, Geerten P. van Nieuw Amerongen, Jan A. Rauwerda, Coen D.A. Stehouwer

Publikováno v: Journal of Molecular and Cellular Cardiology, 49(5), 781-790. Academic Press Inc.
Journal of molecular and cellular cardiology, 49(5), 781-790. Academic Press Inc.
Krijnen, P A J, Sipkens, J A, Molling, J W, Rauwerda, J A, Stehouwer, C D A, Muller, A, Paulus, W J, van Nieuw Amerongen, G P, Hack, C E, Verhoeven, A J, van Hinsbergh, V W M & Niessen, H W M 2010, ' Inhibition of Rho-ROCK signaling induces apoptotic and non-apoptotic PS exposure in cardiomyocytes via inhibition of flippase ', Journal of Molecular and Cellular Cardiology, vol. 49, no. 5, pp. 781-790 . https://doi.org/10.1016/j.yjmcc.2010.07.017
Journal of Molecular and Cellular Cardiology, 49(5), 781-790. ELSEVIER SCI LTD

Subsequent to myocardial infarction, cardiomyocytes within the infarcted areas and border zones expose phosphatidylserine (PS) in the outer plasma membrane leaflet (flip-flop). We showed earlier that in addition to apoptosis, this flip-flop can be re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83ef9bb47890a08edcefab3a3da97f18
https://doi.org/10.1016/j.yjmcc.2010.07.017

Circulating Vα24+Vβ11+ NKT cell numbers and dendritic cell CD1d expression in hepatitis C virus infected patients

Autor: Wendy Kölgen, Anita G.M. Stam, Johan W. Molling, Chris J. J. Mulder, Alfons J.M. van den Eertwegh, Tanja D. de Gruijl, Rik J. Scheper, Nobusuke Nishi, Carin J.M. van Nieuwkerk, Hans van Vliet, Harry L.A. Janssen, B. Mary E. von Blomberg

Publikováno v: Clinical Immunology, 114(2), 183-189. Academic Press Inc.
van der Vliet, H J J, Molling, J W, von Blomberg, B M E, Kölgen, W, Stam, A G, de Gruijl, T D, Mulder, C J, Janssen, H L A, Nishi, N, van den Eertwegh, A J M, Scheper, R J & van Nieuwkerk, C J M 2005, ' Circulating Valpha24+Vbeta11+ NKT cell numbers and dendritic cell CD1d expression in hepatitis C virus infected patients ', Clinical Immunology, vol. 114, no. 2, pp. 183-189 . https://doi.org/10.1016/j.clim.2004.10.001
Clinical Immunology, 114(2), 183-189. Academic Press

CD1d-restricted natural killer T (NKT) cells are involved in the regulation of various immune responses, and have been shown to inhibit viral replication in animal hepatitis models when activated by the glycolipid alpha-galactosylceramide (alpha-GalC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46bf867e28f736a005005917947dee9d
https://doi.org/10.1016/j.clim.2004.10.001

The immunoregulatory role of CD1d-restricted natural killer T cells in disease

Autor: Hans van Vliet, Alfons J.M. van den Eertwegh, Nobusuke Nishi, Johan W. Molling, Giuseppe Giaccone, B. Mary E. von Blomberg, Wendy Kölgen, Rik J. Scheper, Herbert M. Pinedo

Publikováno v: van der Vliet, H J J, Molling, J W, von Blomberg, B M E, Nishi, N, Kölgen, W, van den Eertwegh, A J M, Pinedo, H M, Giaccone, G & Scheper, R J 2004, ' The immunoregulatory role of CD1d-restricted natural killer T cells in disease ', Clinical Immunology, vol. 112, no. 1, pp. 8-23 . https://doi.org/10.1016/j.clim.2004.03.003

Natural killer T (NKT) cells constitute a T cell subpopulation that shares several characteristics with NK cells. NKT cells are characterized by a narrow T cell antigen receptor (TCR) repertoire, recognize glycolipid antigen in the context of the mon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c81f253f119f526d2fc976c0d67ac10
https://hdl.handle.net/1871/26199

IFN-gamma-producing human invariant NKT cells promote tumor-associated antigen-specific cytotoxic T cell responses

Autor: Duco Kramer, Anneke W. Reurs, Johan W. Molling, Rik J. Scheper, René H.M. Verheijen, B. Mary E. von Blomberg, Hetty J. Bontkes, Silvia von Mensdorff-Pouilly, María Moreno, Alfons J.M. van den Eertwegh, Erik Hooijberg

Publikováno v: Journal of Immunology, 181, 4, pp. 2446-54
Journal of Immunology, 181(4), 2446-2454. American Association of Immunologists
Journal of Immunology, 181, 2446-54
Moreno, M, Molling, J W, von Mensdorff-Pouilly, S, Verheijen, R H M, Hooijberg, E, Kramer, D, Reurs, A W, van den Eertwegh, A J M, von Blomberg, B M E, Scheper, R J & Bontkes, H J 2008, ' IFN-gamma-producing human invariant NKT cells promote tumor-associated antigen-specific cytotoxic T cell responses ', Journal of Immunology, vol. 181, no. 4, pp. 2446-2454 . https://doi.org/10.4049/jimmunol.181.4.2446

Contains fulltext : 69909.pdf (Publisher’s version ) (Closed access) CD1d-restricted invariant NKT (iNKT) cells can enhance immunity to cancer or prevent autoimmunity, depending on the cytokine profile secreted. Antitumor effects of the iNKT cell l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de17da8fd229a7aba843ad9aab8c42b9
https://hdl.handle.net/2066/69909

TLR ligands in the local treatment of established intracerebral murine gliomas

Autor: Erik Bennink, Roger P.M. Sutmuller, Johan W. Molling, Gosse J. Adema, Stefan Nierkens, Liza W.J. Toonen, Oliver Grauer

Publikováno v: Journal of Immunology, 181, 6720-9
Journal of Immunology, 181, 10, pp. 6720-9

Contains fulltext : 70899.pdf (Publisher’s version ) (Closed access) Local TLR stimulation is an attractive approach to induce antitumor immunity. In this study, we compared various TLR ligands for their ability to affect murine GL261 cells in vitr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa51b80ed73764786bb64be99340f058
https://doi.org/10.4049/jimmunol.181.10.6720