Zobrazeno 1 - 10
of 150
pro vyhledávání: '"Johan W, Jonker"'
Autor:
Matilda E. Arvidsson Kvissberg, Guanlan Hu, Lijun Chi, Celine Bourdon, Cino Ling, YueYing ChenMi, Kyla Germain, Ivo P. van Peppel, Linnea Weise, Ling Zhang, Valeria Di Giovanni, Nathan Swain, Johan W. Jonker, Peter Kim, Robert Bandsma
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Severe malnutrition accounts for half-a-million deaths annually in children under the age of five. Despite improved WHO guidelines, inpatient mortality remains high and is associated with metabolic dysfunction. Previous studies suggest a cor
Externí odkaz:
https://doaj.org/article/bd8a9c46adfc408580b180d25e839e27
Autor:
Catriona Ling, Christian J. Versloot, Matilda E. Arvidsson Kvissberg, Guanlan Hu, Nathan Swain, José M. Horcas-Nieto, Emily Miraglia, Mehakpreet K. Thind, Amber Farooqui, Albert Gerding, Karen van Eunen, Mirjam H. Koster, Niels J. Kloosterhuis, Lijun Chi, YueYing ChenMi, Miriam Langelaar-Makkinje, Celine Bourdon, Jonathan Swann, Marieke Smit, Alain de Bruin, Sameh A. Youssef, Marjon Feenstra, Theo H. van Dijk, Kathrin Thedieck, Johan W. Jonker, Peter K. Kim, Barbara M. Bakker, Robert H.J. Bandsma
Publikováno v:
EBioMedicine, Vol 96, Iss , Pp 104809- (2023)
Summary: Background: The intestine of children with severe malnutrition (SM) shows structural and functional changes that are linked to increased infection and mortality. SM dysregulates the tryptophan-kynurenine pathway, which may impact processes s
Externí odkaz:
https://doaj.org/article/030dcd61c99342418554af2a1f59e28d
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
Beta klotho (KLB) is a fundamental component in fibroblast growth factor receptor (FGFR) signaling as it serves as an obligatory coreceptor for the endocrine hormones fibroblast growth factor 19 (FGF19) and fibroblast growth factor 21 (FGF21). Throug
Externí odkaz:
https://doaj.org/article/e9988dd8d39a4488a1bd44ac227a3006
Autor:
Maaike Blankestijn, Vincent W. Bloks, Dicky Struik, Nicolette Huijkman, Niels Kloosterhuis, Justina C. Wolters, Ronald J. A. Wanders, Frédéric M. Vaz, Markus Islinger, Folkert Kuipers, Bart van de Sluis, Albert K. Groen, Henkjan J. Verkade, Johan W. Jonker
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Peroxisomes play an important role in the metabolism of a variety of biomolecules, including lipids and bile acids. Peroxisomal Membrane Protein 4 (PXMP4) is a ubiquitously expressed peroxisomal membrane protein that is transcriptionally reg
Externí odkaz:
https://doaj.org/article/4641e716dcdd48d6b1399eb16d2429df
Autor:
Lars E. Larsen, Marjolein A.W. van den Boogert, Wilson A. Rios-Ocampo, Jos C. Jansen, Donna Conlon, Patrick L.E. Chong, J. Han M. Levels, Roos E. Eilers, Vinay V. Sachdev, Noam Zelcer, Tobias Raabe, Miao He, Nicholas J. Hand, Joost P.H. Drenth, David J. Rader, Eric S.G. Stroes, Dirk J. Lefeber, Johan W. Jonker, Adriaan G. Holleboom
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 2, Pp 583-597 (2022)
Background & Aims: Recently, novel inborn errors of metabolism were identified because of mutations in V-ATPase assembly factors TMEM199 and CCDC115. Patients are characterized by generalized protein glycosylation defects, hypercholesterolemia, and f
Externí odkaz:
https://doaj.org/article/f83a6ee89be64fb6964bdd0493f8352e
Autor:
Marcel A. Vieira-Lara, Marleen B. Dommerholt, Wenxuan Zhang, Maaike Blankestijn, Justina C. Wolters, Fentaw Abegaz, Albert Gerding, Ydwine T. van der Veen, Rachel Thomas, Ronald P. van Os, Dirk-Jan Reijngoud, Johan W. Jonker, Janine K. Kruit, Barbara M. Bakker
Publikováno v:
BMC Biology, Vol 19, Iss 1, Pp 1-18 (2021)
Abstract Background The skeletal muscle plays a central role in glucose homeostasis through the uptake of glucose from the extracellular medium in response to insulin. A number of factors are known to disrupt the normal response to insulin leading to
Externí odkaz:
https://doaj.org/article/a9716da0b74d420cb0e3c1ac024d69e9
Autor:
Lori W. E. van der Schoor, Henkjan J. Verkade, Anna Bertolini, Sanne de Wit, Elvira Mennillo, Eva Rettenmeier, André A. Weber, Rick Havinga, Petra Valášková, Jana Jašprová, Dicky Struik, Vincent W. Bloks, Shujuan Chen, Andrea B. Schreuder, Libor Vítek, Robert H. Tukey, Johan W. Jonker
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Neonatal hyperbilirubinemia or jaundice is associated with kernicterus, resulting in permanent neurological damage or even death. Conventional phototherapy does not prevent hyperbilirubinemia or eliminate the need for exchange transfusion. H
Externí odkaz:
https://doaj.org/article/59f5708413df43f992dcb9093f632208
Autor:
Cristy R.C. Verzijl, Federico Oldoni, Natalia Loaiza, Justina C. Wolters, Antoine Rimbert, E. Tian, Weiming Yang, Dicky Struik, Marieke Smit, Niels J. Kloosterhuis, Amy J. Fernandez, Nadine L. Samara, Kelly G. Ten Hagen, Kruti Dalal, Aliona Chernish, Peggy McCluggage, Lawrence A. Tabak, Johan W. Jonker, Jan Albert Kuivenhoven
Publikováno v:
Molecular Metabolism, Vol 60, Iss , Pp 101472- (2022)
Objective: GALNT2, encoding polypeptide N-acetylgalactosaminyltransferase 2 (GalNAc-T2), was initially discovered as a regulator of high-density lipoprotein metabolism. GalNAc-T2 is known to exert these effects through post-translational modification
Externí odkaz:
https://doaj.org/article/ed1b5a2f73a641f4a58ccdb15e609510
Autor:
Pauline T. Ikpa, Marcela Doktorova, Kelly F. Meijsen, Natascha D.A. Nieuwenhuijze, Henkjan J. Verkade, Johan W. Jonker, Hugo R. de Jonge, Marcel J.C. Bijvelds
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 9, Iss 1, Pp 47-60 (2020)
Background & Aims: The bile acid (BA)-activated farnesoid X receptor (FXR) controls hepatic BA synthesis and cell proliferation via the intestinal hormone fibroblast growth factor 19. Because cystic fibrosis (CF) is associated with intestinal dysbios
Externí odkaz:
https://doaj.org/article/0a415309b75c4917861654a9a812df3d
Autor:
Ivo P. van de Peppel, Anna Bertolini, Theo H. van Dijk, Albert K. Groen, Johan W. Jonker, Henkjan J. Verkade
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 9, Pp 1562-1572 (2019)
Transintestinal cholesterol excretion (TICE) is a major route for eliminating cholesterol from the body and a potential therapeutic target for hypercholesterolemia. The underlying mechanism, however, is largely unclear, and its contribution to choles
Externí odkaz:
https://doaj.org/article/981e13cd35934e3b9f41e82dcafc4319