Zobrazeno 1 - 10
of 230
pro vyhledávání: '"Johan Van der Vlag"'
Autor:
Anouk I. M. van der Velden, Daphne H. T. IJpelaar, Prataap K. Chandie Shaw, Hanno Pijl, Hans Vink, Johan van der Vlag, Ton J. Rabelink, Bernard M. van den Berg
Publikováno v:
Nutrition & Diabetes, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Background/objectives We investigated whether dietary interventions, i.e. a fasting mimicking diet (FMD, Prolon®) or glycocalyx mimetic supplementation (EndocalyxTM) could stabilize microvascular function in Surinamese South-Asian patients
Externí odkaz:
https://doaj.org/article/373be25e13e74799b7e09d41ab453eda
Autor:
Maaike M.E. Jacobs, Rianne J.F. Maas, Inge Jonkman, Yutaka Negishi, Willem Tielemans Zamora, Cansu Yanginlar, Julia van Heck, Vasiliki Matzaraki, Joost H.A. Martens, Marijke Baltissen, Michiel Vermeulen, Judit Morla-Folch, Anna Ranzenigo, William Wang, Martin Umali, Jordi Ochando, Johan van der Vlag, Luuk B. Hilbrands, Leo A.B. Joosten, Mihai G. Netea, Willem J.M. Mulder, Mandy M.T. van Leent, Musa M. Mhlanga, Abraham J.P. Teunissen, Nils Rother, Raphaël Duivenvoorden
Publikováno v:
Cell Reports, Vol 43, Iss 9, Pp 114664- (2024)
Summary: Trained immunity is characterized by histone modifications and metabolic changes in innate immune cells following exposure to inflammatory signals, leading to heightened responsiveness to secondary stimuli. Although our understanding of the
Externí odkaz:
https://doaj.org/article/ad03aab3985e4aec8f638ad9ab1291e2
Autor:
Rosalie G. J. Rietjens, Gangqi Wang, Anouk I. M. van der Velden, Angela Koudijs, M. Cristina Avramut, Sander Kooijman, Patrick C. N. Rensen, Johan van der Vlag, Ton J. Rabelink, Bram Heijs, Bernard M. van den Berg
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Diabetes is a main risk factor for kidney disease, causing diabetic nephropathy in close to half of all patients with diabetes. Metabolism has recently been identified to be decisive in cell fate decisions and repair. Here we used mass spect
Externí odkaz:
https://doaj.org/article/b63da834cde7487bb1afc2fd5be2ce99
Autor:
Nils Rother, Cansu Yanginlar, Geoffrey Prévot, Inge Jonkman, Maaike Jacobs, Mandy M.T. van Leent, Julia van Heck, Vasiliki Matzaraki, Anthony Azzun, Judit Morla-Folch, Anna Ranzenigo, William Wang, Roy van der Meel, Zahi A. Fayad, Niels P. Riksen, Luuk B. Hilbrands, Rik G.H. Lindeboom, Joost H.A. Martens, Michiel Vermeulen, Leo A.B. Joosten, Mihai G. Netea, Willem J.M. Mulder, Johan van der Vlag, Abraham J.P. Teunissen, Raphaël Duivenvoorden
Publikováno v:
Cell Reports, Vol 42, Iss 12, Pp 113458- (2023)
Summary: Innate immune memory, also called ''trained immunity,'' is a functional state of myeloid cells enabling enhanced immune responses. This phenomenon is important for host defense, but also plays a role in various immune-mediated conditions. We
Externí odkaz:
https://doaj.org/article/dff74b8c0faf4120b0eff5cf97c0a2a4
Autor:
Baranca Buijsers, Marissa Maciej-Hulme, Maaike Jacobs, Marinka Bakker-van Bebber, Mark de Graaf, Rustem Salmenov, Naomi Parr, Ton J. Rabelink, Tom Nijenhuis, Johan van der Vlag
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Background: The glomerular endothelial glycocalyx is degraded during inflammation. The glycocalyx plays a pivotal role in endothelial function and is involved in many processes including binding of chemokines and cytokines, leukocyte trafficking, and
Externí odkaz:
https://doaj.org/article/e7f447c01fb342f88f0e14da9da33b64
Autor:
Marissa L. Maciej-Hulme, Jasper J. Van Gemst, Patience Sanderson, Angelique L. W. M. M. Rops, Jo H. Berden, Bart Smeets, I. Jonathan Amster, Ton J. Rabelink, Johan Van Der Vlag
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Proliferative forms of glomerulonephritis are characterized by the influx of leukocytes, albuminuria, and loss of kidney function. The glomerular endothelial glycocalyx is a thick carbohydrate layer that covers the endothelium and is comprised of hep
Externí odkaz:
https://doaj.org/article/5060c46b8253413ba7b4953347efe22b
Autor:
Baranca Buijsers, Marjolein Garsen, Mark de Graaf, Marinka Bakker-van Bebber, Chunming Guo, Xue Li, Johan van der Vlag
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Introduction: The endothelial glycocalyx degrading enzyme heparanase-1 (HPSE1) is a major contributor to kidney diseases, such as glomerulonephritis and diabetic nephropathy. Therefore, inhibition of HPSE1 could be an interesting therapeutic strategy
Externí odkaz:
https://doaj.org/article/a7517a03f86d40e8a0e1cafc4440f22e
Autor:
Marjolein Garsen, Baranca Buijsers, Marloes Sol, Lena Gockeln, Ramon Sonneveld, Toin H. van Kuppevelt, Mark de Graaf, Jacob van den Born, Jan A.A.M. Kamps, Daniël H. van Raalte, Rutger W. van der Meer, Hildo J. Lamb, Jan-Luuk Hillebrands, Ton J. Rabelink, Marissa L. Maciej-Hulme, Guido Krenning, Tom Nijenhuis, Johan van der Vlag
Publikováno v:
EBioMedicine, Vol 90, Iss , Pp 104506- (2023)
Summary: Background: Proteinuria is associated with many glomerular diseases and a risk factor for the progression to renal failure. We previously showed that heparanase (HPSE) is essential for the development of proteinuria, whereas peroxisome proli
Externí odkaz:
https://doaj.org/article/13deeeb23f314fa5bfa8672de7b2f11d
Autor:
Rachel P. L. van Swelm, Sanne Beurskens, Henry Dijkman, Erwin T. G. Wiegerinck, Rian Roelofs, Frank Thévenod, Johan van der Vlag, Jack F. M. Wetzels, Dorine W. Swinkels, Bart Smeets
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Kidney iron deposition may play a role in the progression of tubulointerstitial injury during chronic kidney disease. Here, we studied the molecular mechanisms of kidney iron loading in experimental focal segmental glomerulosclerosis (FSGS)
Externí odkaz:
https://doaj.org/article/aa89f4d3a9384e2299ca2096925f5c50
Autor:
Carolin Christina Drost, Alexandros Rovas, Irina Osiaevi, Matthias Rauen, Johan van der Vlag, Baranca Buijsers, Rustem Salmenov, Alexander Lukasz, Hermann Pavenstädt, Wolfgang A. Linke, Philipp Kümpers
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Coronavirus disease 2019 (COVID-19) is a systemic disease associated with injury (thinning) of the endothelial glycocalyx (eGC), a protective layer on the vascular endothelium. The aim of this translational study was to investigate the role of the eG
Externí odkaz:
https://doaj.org/article/b9670e766de24508a8ffda2591dc44df