Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Johan Van Lint"'
Autor:
Dries Bauters, Mathias Cobbaut, Lotte Geys, Johan Van Lint, Bianca Hemmeryckx, H. Roger Lijnen
Publikováno v:
Molecular Metabolism, Vol 6, Iss 7, Pp 715-724 (2017)
Objective: A potential strategy to treat obesity – and the associated metabolic consequences – is to increase energy expenditure. This could be achieved by stimulating thermogenesis through activation of brown adipose tissue (BAT) and/or the indu
Externí odkaz:
https://doaj.org/article/2e8a1e71b15a490785e407281c9b81b0
Autor:
Mathias Cobbaut, Rita Derua, Heike Döppler, Hua Jane Lou, Sandy Vandoninck, Peter Storz, Benjamin E. Turk, Thomas Seufferlein, Etienne Waelkens, Veerle Janssens, Johan Van Lint
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-17 (2017)
Abstract Protein kinases are essential molecules in life and their crucial function requires tight regulation. Many kinases are regulated via phosphorylation within their activation loop. This loop is embedded in the activation segment, which additio
Externí odkaz:
https://doaj.org/article/896f3c5473c54c7cb5cb393a684923cf
Autor:
Thomas Seufferlein, Claudia Scholl, Stefan Fröhling, John Koren, Gabriela Chiosis, Johan van Lint, Hans Kestler, Alexander Becher, Felicitas Genze, Arefeh Rouhi, Cornelia Brunner, Kristina Diepold, Ninel Azoitei
Supplementary Figure S4. HSP90 inhibition impairs tumor growth in vivo in a PRKD2-dependent manner.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45e7472c2655a483e5d4463c06336d14
https://doi.org/10.1158/0008-5472.22405673
https://doi.org/10.1158/0008-5472.22405673
Autor:
Thomas Seufferlein, Claudia Scholl, Stefan Fröhling, John Koren, Gabriela Chiosis, Johan van Lint, Hans Kestler, Alexander Becher, Felicitas Genze, Arefeh Rouhi, Cornelia Brunner, Kristina Diepold, Ninel Azoitei
Supplementary Figure Legend. Legend for Supplementary Figures S1-S7.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e158f575db770e38a67cfab73a0bb07
https://doi.org/10.1158/0008-5472.22405685.v1
https://doi.org/10.1158/0008-5472.22405685.v1
Publikováno v:
ChemMedChem. 16:2158-2171
Protein kinase D (PKD) is a serine/threonine kinase family belonging to the Ca2+/calmodulin-dependent protein kinase group. Since its discovery two decades ago, many efforts have been put in elucidating PKD's structure, cellular role and functioning.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9f34b334b6ee2d5456a87d393ab9d43
https://doi.org/10.1002/cmdc.202100110
https://doi.org/10.1002/cmdc.202100110
Autor:
Maria João Freitas, Steven De Jonghe, Sam Ceusters, Arnout Voet, Mathias Cobbaut, Dirk Daelemans, Koen Van Asch, Johan Van Lint, Rudra Kashyap, Anke Janssens, Philippe Gilles, Leentje Persoons, Wim M. De Borggraeve
The multiple roles of protein kinase D (PKD) in various cancer hallmarks have been repeatedly reported. Therefore, the search for novel PKD inhibitors and their evaluation as antitumor agents has gained considerable attention. In this work, novel pyr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d10f8fc9d70fc54d72e8ca4755001d2a
https://lirias.kuleuven.be/handle/123456789/659296
https://lirias.kuleuven.be/handle/123456789/659296
Autor:
Peter J. Parker, Johan Van Lint, Mathias Cobbaut, Veerle Janssens, Rita Derua, Etienne Waelkens
Publikováno v:
Febs Letters
The protein kinase D (PKD) family is regulated through multi-site phosphorylation, including autophosphorylation. For example, PKD displays in vivo autophosphorylation on Ser-742 (and Ser-738 in vitro) in the activation loop and Ser-910 in the C-tail
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e2ae121d55a52df200f9381bc6ab608
https://doi.org/10.1002/1873-3468.13171
https://doi.org/10.1002/1873-3468.13171
Autor:
Rudra Kashyap, Johan Van Lint, Olivia Appelmans, Arnout Voet, Wim M. De Borggraeve, Philippe Gilles
Publikováno v:
Analytical Biochemistry. 630:114313
Radiometric assays have widely been used for measuring protein kinase activity for decades. In addition, several non-radiometric kinase assay formats have been developed over the years, including luciferase-based and fluorescence-based assays. Howeve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80906c37870ebe8af1fe19d56c320eb5
https://doi.org/10.1016/j.ab.2021.114313
https://doi.org/10.1016/j.ab.2021.114313
Autor:
Johan Van Lint, Lotte Geys, Mathias Cobbaut, Dries Bauters, H. Roger Lijnen, Bianca Hemmeryckx
Publikováno v:
Molecular Metabolism, Vol 6, Iss 7, Pp 715-724 (2017)
Molecular Metabolism
Molecular Metabolism
Objective A potential strategy to treat obesity – and the associated metabolic consequences – is to increase energy expenditure. This could be achieved by stimulating thermogenesis through activation of brown adipose tissue (BAT) and/or the induc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2d92e3dc50d40e06aca840114cb1b9c
http://www.sciencedirect.com/science/article/pii/S2212877817302818
http://www.sciencedirect.com/science/article/pii/S2212877817302818
Autor:
Wim M. De Borggraeve, Lina Saadah, Johan Van Lint, Mathias Cobbaut, Arnout Voet, Klaas Verschueren, Joachim Demaerel
Publikováno v:
MedChemComm. 8:640-646
In this study, we set out to rationally optimize PKD inhibitors based on the pyrazolo[3,4-d]pyrimidine scaffold. The lead compound for this study was 1-NM-PP1, which was previously found by us and others to inhibit PKD. In our screening we identified
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c2c31f72905cc507c48809f53a82c24
https://doi.org/10.1039/c6md00675b
https://doi.org/10.1039/c6md00675b