Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Johan Van Es"'
Autor:
Martina Celotti, Lucca L.M. Derks, Johan van Es, Ruben van Boxtel, Hans Clevers, Maarten H. Geurts
Publikováno v:
STAR Protocols, Vol 5, Iss 3, Pp 103189- (2024)
Summary: Isogenic disease models, such as genetically engineered organoids, provide insight into the impact of genetic variants on organ function. Here, we present a protocol to create isogenic disease models from adult stem cell-derived organoids us
Externí odkaz:
https://doaj.org/article/4aa9ad949e6c44b6be56e5953d17244b
Autor:
Felix Broghammer, Irina Korovina, Mahesh Gouda, Martina Celotti, Johan van Es, Inga Lange, Cornelia Brunner, Jovan Mircetic, Robert P. Coppes, Olivier Gires, Andreas Dahl, Michael Seifert, Nils Cordes
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-25 (2024)
Abstract Background Focal adhesion signaling involving receptor tyrosine kinases (RTK) and integrins co-controls cancer cell survival and therapy resistance. However, co-dependencies between these receptors and therapeutically exploitable vulnerabili
Externí odkaz:
https://doaj.org/article/ded1a485f83747baa803adfa3ea0b8c8
Autor:
Marco Calafiore, Ya-Yuan Fu, Paola Vinci, Viktor Arnhold, Winston Y. Chang, Suze A. Jansen, Anastasiya Egorova, Shuichiro Takashima, Jason Kuttiyara, Takahiro Ito, Jonathan Serody, Susumu Nakae, Heth Turnquist, Johan van Es, Hans Clevers, Caroline A. Lindemans, Bruce R. Blazar, Alan M. Hanash
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Intestinal stem cells (ISCs) maintain the epithelial lining of the intestines, but mechanisms regulating ISCs and their niche after damage remain poorly understood. Utilizing radiation injury to model intestinal pathology, we report here tha
Externí odkaz:
https://doaj.org/article/9b625ca7598346a7aef6d804ad1b9d63
Publikováno v:
Stem Cell Reports, Vol 3, Iss 2, Pp 234-241 (2014)
The epithelium of the small intestine is the most rapidly self-renewing tissue in mammals. We previously demonstrated the existence of a long-lived pool of cycling stem cells defined by Lgr5 expression at the bottom of intestinal crypts. An Lgr5-eGFP
Externí odkaz:
https://doaj.org/article/14816697cf94499b965e9956184987f9
Autor:
Merixtell Huch, Paola Bonfanti, Sylvia Boj, Toshiro Sato, Cindy Loomans, Marc van de Wetering, Mozhdeh Sojoodi, Vivian Li, Jurian Schuijers, Ana Gracanin, Femke Ringnalda, Harry Begthel, Karien Hamer, Joyce Mulder, Johan Van Es, Eelco De Koning, Robert Vries, Harry Heimberg, Hans Clevers
Publikováno v:
Vrije Universiteit Brussel
Lgr5 marks adult stem cells in multiple adult organs and is a receptor for the Wnt-agonistic R-spondins (RSPOs). Intestinal, stomach and liver Lgr5(+) stem cells grow in 3D cultures to form ever-expanding organoids, which resemble the tissues of orig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::6f96173044cb4b1c2bf97d7051e156a7
https://researchportal.vub.be/en/publications/79e9299f-d0e3-4cc7-9136-a920a0cde5b0
https://researchportal.vub.be/en/publications/79e9299f-d0e3-4cc7-9136-a920a0cde5b0
Autor:
Klijs Jacob de Koning, Jan Willem Dankbaar, Bart de Keizer, Koen Willemsen, Annette van der Toorn, Gerben Eise Breimer, Robert Jelle Johan van Es, Remco de Bree, Rob Noorlag, Marielle Emile Petronella Philippens
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
ObjectiveThis study explores the feasibility of ex-vivo high-field magnetic resonance (MR) imaging to create digital a three-dimensional (3D) representations of tongue cancer specimens, referred to as the “MR-based digital specimen” (MR-DS). The
Externí odkaz:
https://doaj.org/article/9ff3fbff0b344cacb310589dde759321