Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Johan Teleman"'
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Protein structure determination in complex biological samples is still challenging. Here, the authors develop a computational modeling-guided cross-linking mass spectrometry method, obtaining a high-resolution model of a 1.8 MDa protein assembly from
Externí odkaz:
https://doaj.org/article/c4ea55d53e294d409643497524b1ae3d
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Nature Communications
Nature Communications
The understanding of complex biological systems is still hampered by limited knowledge of biologically relevant quaternary protein structures. Here, we demonstrate quaternary structure determination in biological samples using a combination of chemic
Publikováno v:
Journal of Proteome Research. 14:676-687
High-throughput multiplexed protein quantification using mass spectrometry is steadily increasing in popularity, with the two major techniques being data-dependent acquisition (DDA) and targeted acquisition using selected reaction monitoring (SRM). H
Autor:
Johan Teleman, Hannes L. Röst, Johan Malmström, George Rosenberger, Lars Malmström, Fredrik Levander, Uwe Schmitt
Publikováno v:
Bioinformatics; 31(4), pp 555-562 (2015)
Motivation: Data independent acquisition mass spectrometry has emerged as a reproducible and sensitive alternative in quantitative proteomics, where parsing the highly complex tandem mass spectra requires dedicated algorithms. Recently, targeted data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6f97b99875458f88a9cde2b7215ef43
http://doc.rero.ch/record/293223/files/btu686.pdf
http://doc.rero.ch/record/293223/files/btu686.pdf
Publikováno v:
Journal of proteome research. 16(7)
In data-independent acquisition mass spectrometry (DIA-MS), targeted extraction of peptide signals in silico using mass spectrometry assay libraries is a successful method for the identification and quantification of proteins. However, it remains unc
Autor:
Lotta Happonen, Johan Teleman, Lars Malmström, Ola Kilsgård, Kristoffer Sjöholm, Johan Malmström
Sepsis is a systemic immune response responsible for considerable morbidity and mortality. Molecular modeling of host-pathogen interactions in the disease state represents a promising strategy to define molecular events of importance for the transiti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3586e7e5d785f0f84bfbf3c828d91c25
https://europepmc.org/articles/PMC5393399/
https://europepmc.org/articles/PMC5393399/
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1535
Host-pathogen protein-protein interaction networks are highly complex and dynamic. In this experimental protocol we describe a method to isolate host proteins attached to the bacterial surface followed by quantitative mass spectrometry based proteomi
Publikováno v:
Journal of Proteome Research
ResearcherID
ResearcherID
In bottom-up mass spectrometry (MS)-based proteomics, peptide isotopic and chromatographic traces (features) are frequently used for label-free quantification in data-dependent acquisition MS but can also be used for the improved identification of ch
Autor:
Karin M Hansson, Johan Teleman, Peter James, Christofer Karlsson, Fredrik Levander, Johan Malmström, Sofia Waldemarson
Publikováno v:
Journal of Proteome Research
Selected reaction monitoring (SRM) is a mass spectrometry method with documented ability to quantify proteins accurately and reproducibly using labeled reference peptides. However, the use of labeled reference peptides becomes impractical if large nu
Autor:
Gabriel Grubb, Johan Malmström, Johan Teleman, Martin Sjöström, Erik Malmström, Markus Stenemo, Emma Niméus
Publikováno v:
Proteomics. 16(13)
Protein biomarkers have the potential to improve diagnosis, stratification of patients into treatment cohorts, follow disease progression and treatment response. One distinct group of potential biomarkers comprises proteins which have been linked to