Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Johan Riesenfeld"'
Publikováno v:
Journal of Biomedical Materials Research Part B: Applied Biomaterials. 102:1817-1824
Immobilization of heparin to surfaces has been used for decades to reduce the thrombogenicity of blood contacting devices. This study evaluates how the mode of covalent heparin bonding affects the hemocompatibility and uptake of antithrombin on surfa
Autor:
Anne Pharo, Dorte Christiansen, Johan Riesenfeld, Tom Eirik Mollnes, Michael Fung, Hilde Fure, Ole-Lars Brekke
Publikováno v:
Molecular Immunology. 45:3804-3813
The relative role of complement and CD14 in E. coli-induced cytokine synthesis in an in vitro human whole blood model of sepsis was examined. Fresh lepirudin-anticoagulated whole blood was incubated with E. coli for 2h. Monoclonal antibodies or a C5a
Autor:
Grethe Bergseth, John D. Lambris, Ole-Lars Brekke, Johan Riesenfeld, Tom Eirik Mollnes, Knut Tore Lappegård
Publikováno v:
The Annals of Thoracic Surgery. 79:917-923
Background Contact between blood and artificial surfaces induces an inflammatory response including activation of leukocytes and platelets, as well as complement and other plasma cascade systems. In the present study we investigated the roles of comp
Publikováno v:
Journal of Biomedical Materials Research Part A. :230-236
In an in vitro whole blood model of artificial surface-induced inflammation, we have studied the contribution of leukocyte populations in the synthesis of inflammatory mediators. This was done by depleting the blood of specific cell types using magne
Publikováno v:
The Annals of Thoracic Surgery. 78:38-44
Background Contact between blood and artificial surfaces induces an inflammatory response including activation of leukocytes and platelets, as well as complement and other plasma cascade systems. In the present study we investigated the roles of comp
Autor:
Grethe Bergseth, Johan Riesenfeld, Vibeke Videm, Michael Fung, Knut Tore Lappegård, John D. Lambris, Tom Eirik Mollnes
Publikováno v:
The Annals of Thoracic Surgery. 77:932-941
Background Exposure of blood to artificial surfaces, as in cardiopulmonary bypass, induces an inflammatory response involving complement, leukocyte and platelet activation. To elucidate the specific role of complement in this process, studies were pe
Publikováno v:
Thrombosis Research. 89:41-50
The aim of the present investigation was to clarify whether immobilized heparin does, as previously suggested, prevent triggering of the plasma contact activation system. Purified FXII in the absence or presence of antithrombin and/or C1 esterase inh
Publikováno v:
Journal of Biomedical Materials Research. 37:37-42
End-point immobilization of heparin to artificial materials gives rise to a surface that prevents triggering of the plasma contact activation system and, presumably as a result thereof, generally has thrombo-resistant properties. The present investig
Publikováno v:
Journal of biomedical materials research. Part B, Applied biomaterials. 102(8)
Immobilization of heparin to surfaces has been used for decades to reduce the thrombogenicity of blood contacting devices. This study evaluates how the mode of covalent heparin bonding affects the hemocompatibility and uptake of antithrombin on surfa
Autor:
Johan Riesenfeld, Campbell Rogers, Jonathon Z Zhao, Theodore L. Parker, Yan Cheng, Thai Minh Nguyen, Vipul Dave, Robert Falotico
Publikováno v:
Journal of biomedical materials research. Part B, Applied biomaterials. 100(5)
Low-molecular weight heparin (LMWH) has been widely used as a systemic anticoagulant during percutaneous coronary intervention. In this study, LMWH was covalently immobilized to the surface of a cobalt chromium reservoir-based sirolimus-eluting stent