Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Johan Renes"'
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 16, p 4055 (2019)
Adipose tissue is a major endocrine organ capable of secreting adipokines with a role in whole-body metabolism. Changes in the secretome profile during the development of obesity is suspected to contribute to the risk of health complications such as
Externí odkaz:
https://doaj.org/article/75a831b7aa2f496b959e580fa3b233ab
Autor:
Yuan Tian, Aize Kijlstra, Johan Renes, Martin Wabitsch, Carroll A. B. Webers, Tos T. J. M. Berendschot
Publikováno v:
Journal of Ophthalmology, Vol 2015 (2015)
Purpose. Complement plays an important role in the pathogenesis of age related macular degeneration (AMD) and trials are currently being conducted to investigate the effect of complement inhibition on AMD progression. We previously found that the pla
Externí odkaz:
https://doaj.org/article/f00d4f8617df4b2594097fb15d47447b
Publikováno v:
Journal of Cellular and Molecular Medicine
Journal of Cellular and Molecular Medicine, 24(15), 8662-8673. Wiley-Blackwell
Journal of Cellular and Molecular Medicine, 24(15), 8662-8673. Wiley-Blackwell
Obesity is the consequence of a positive energy balance and characterized by enlargement of the adipose tissue, which in part is due to hyperplasia and hypertrophy of the adipocytes. Not much is known about the transition of normal mature adipocytes
Autor:
Susan L. Coort, Nadia J. T. Roumans, Qi Qiao, Johan Renes, Edwin C. M. Mariman, Roel G. Vink, Freek G. Bouwman, Marleen A. van Baak
Publikováno v:
Adipocyte, Vol 8, Iss 1, Pp 190-200 (2019)
Adipocyte
Adipocyte, 8(1), 190-200. Routledge/Taylor & Francis Group
Adipocyte
Adipocyte, 8(1), 190-200. Routledge/Taylor & Francis Group
Long-term weight loss maintenance is a problem of overweight and obesity. Changes of gene expression during weight loss (WL) by calorie restriction (CR) are linked to the risk of weight regain (WR). However, detailed information on genes/proteins inv
Publikováno v:
International journal of molecular sciences, 20(16):4055. Multidisciplinary Digital Publishing Institute (MDPI)
International Journal of Molecular Sciences
Volume 20
Issue 16
International Journal of Molecular Sciences, Vol 20, Iss 16, p 4055 (2019)
International Journal of Molecular Sciences
Volume 20
Issue 16
International Journal of Molecular Sciences, Vol 20, Iss 16, p 4055 (2019)
Adipose tissue is a major endocrine organ capable of secreting adipokines with a role in whole-body metabolism. Changes in the secretome profile during the development of obesity is suspected to contribute to the risk of health complications such as
A comparison between the abdominal and femoral adipose tissue proteome of overweight and obese women
Autor:
Edwin C. M. Mariman, Johan Renes, Gijs H. Goossens, Freek G. Bouwman, Ellen E. Blaak, Ping Wang, M. A. A. Vogel, Nicole Hoebers
Publikováno v:
Scientific Reports, 9:4202, 1-9. Nature Publishing Group
Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
Scientific Reports
Body fat distribution is an important determinant of cardiometabolic health. Lower-body adipose tissue (AT) has protective characteristics as compared to upper-body fat, but the underlying depot-differences remain to be elucidated. Here, we compared
Autor:
Edwin C. M. Mariman, Klaas R. Westerterp, Nadia J. T. Roumans, Stefan G J A Camps, Johan Renes, Freek G. Bouwman
Publikováno v:
British Journal of Nutrition, 115(5), 913-920. Cambridge University Press
Initial successful weight loss is often followed by weight regain after the dietary intervention. Compared with lean people, cellular stress in adipose tissue is increased in obese subjects. However, the relation between cellular stress and the risk
Publikováno v:
Biochimica et Biophysica Acta-Proteins and Proteomics, 1844(9), 1511-1522. Elsevier Science
Obesity is characterized by dysfunctional white adipose tissue (WAT) that ultimately may lead to metabolic diseases. Calorie restriction (CR) reduces the risk for age and obesity-associated complications. The impact of CR on obesity has been examined
Publikováno v:
Biochimica et Biophysica Acta-Proteins and Proteomics, 1834(12), 2761-2771. Elsevier Science
White adipose tissue (WAT) regulates energy metabolism by secretion of proteins with endocrine and paracrine effects. Dysregulation of the secretome of obesity-associated enlarged WAT may lead to obesity-related disorders. This can be caused by hypox
Autor:
Freek G. Bouwman, Jos C. S. Kleinjans, Edwin C. M. Mariman, Daneida Lizarraga, Johan Renes, Joost H.M. van Delft, Jean-Paul Noben, Anke Van Summeren
Publikováno v:
OMICS-a journal of Integrative Biology, 17(2), 71-83. Mary Ann Liebert Inc.
Drug-induced hepatotoxicity is a leading cause of attrition for candidate pharmaceuticals in development. New preclinical screening methods are crucial to predict drug toxicity prior to human studies. Of all in vitro hepatotoxicity models, primary hu