Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Johan Remmelgas"'
Autor:
Liang Li, Johan Remmelgas, Berend G.M. van Wachem, Christian von Corswant, Staffan Folestad, Mats Johansson, Anders Rasmuson
Publikováno v:
KONA Powder and Particle Journal, Vol 33, Iss 0, Pp 264-277 (2015)
Fluidized bed coating has been used to coat pellets or tablets with functional substances for a number of purposes. In this coating process, particle wetting, drying and film formation are coupled to particle motion. It is therefore of interest to st
Externí odkaz:
https://doaj.org/article/2e8f3c54919f4bb1bff239ff24c2c907
Autor:
Anthony Grelier, Matej Zadravec, Johan Remmelgas, Thomas Forgber, Franco Colacino, Gabrielle Pilcer, Fanny Stauffer, Theresa Hörmann-Kincses
Publikováno v:
Pharmaceutical Research. 39:2005-2016
With an increased adoption of continuous manufacturing for pharmaceutical production, the ConsiGma® CTL25 wet granulation and tableting line has reached widespread use. In addition to the continuous granulation step, the semi-continuous six-segmente
Autor:
Andrew Megarry, Håkan Wikström, Frida Bilén, Johan Remmelgas, Alexander Liljeblad, Pirjo Tajarobi
Publikováno v:
International Journal of Pharmaceutics. 635:122765
Autor:
Dario Maggiolo, Johan Malmqvist, Diana Bernin, Maria Daniela Irene Siiskonen, Susanna Abrahmsén-Alami, Povilas Vaitukaitis, Gaetano Sardina, Srdjan Sasic, Johan Remmelgas
Publikováno v:
Meccanica. 55:421-433
The quality of a coated pharmaceutical tablet can be strongly affected by the interactions of water droplets with the porous substrate during processes such as coating process. Three different mechanisms co-exist in the coating process: water spreadi
Autor:
Håkan Wikström, Sara Solin, Johan Remmelgas, Mariagrazia Marucci, Pirjo Tajarobi, Catherine Boissier, Niklas Sandler
Publikováno v:
International journal of pharmaceutics. 597
Powders are usually dispensed, blended, and transferred between different manufacturing steps in so-called Intermediate Bulk Containers (IBCs), and discharge from an IBC plays a critical role in the ability to manufacture high-quality tablets. To bet
Publikováno v:
International Journal of Pharmaceutics. 547:31-43
This work demonstrates the use of multi-scale simulations coupled with experiments to build a quantitative prediction tool for the performance of adhesive mixtures in a dry powder inhaler (DPI). Using discrete element model (DEM), the behaviour of fi
Autor:
Håkan Wikström, Srdjan Sasic, Mariagrazia Marucci, Johan Remmelgas, Henrik Ström, Catherine Boissier, Abdoulaye Fall, Pirjo Tajarobi
Publikováno v:
European Journal of Pharmaceutical Sciences
European Journal of Pharmaceutical Sciences, Elsevier, 2019, pp.105085. ⟨10.1016/j.ejps.2019.105085⟩
European Journal of Pharmaceutical Sciences, Elsevier, 2019, pp.105085. ⟨10.1016/j.ejps.2019.105085⟩
International audience; The objective of this study was to characterize the rheology of a pharmaceutical material in the context of the µ(I)-rheology model and to use this model to predict powder flow in a manufacturing operation that is relevant to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a132fea8682782660e4620c368d8c534
https://hal.archives-ouvertes.fr/hal-02346496
https://hal.archives-ouvertes.fr/hal-02346496
Publikováno v:
AIChE Journal. 63:501-516
The flow of carrier particles, coated with active drug particles, is studied in a prototype dry powder inhaler. A novel, multiscale approach consisting of a discrete element model (DEM) to describe the particles coupled with a dynamic large eddy simu
Autor:
Johan Remmelgas, Anssi-Pekka Karttunen, Anders Sparén, Pirjo Tajarobi, W-K. Hsiao, Staffan Folestad, L. Martin De Juan, Stephan Sacher, Susanna Abrahmsén-Alami, Håkan Wikström, Johannes Poms, Ossi Korhonen, C. Ruiz Samblás, Magnus Fransson
Publikováno v:
International Journal of Pharmaceutics. 574:118882
The aim of the current study was to characterize the robustness of an integrated continuous direct compression (CDC) line against disturbances from feeding, i.e. impulses of API and short step disturbances. These disturbances mimicked typical variati
Autor:
Liang Li, Christian von Corswant, Johan Remmelgas, Berend van Wachem, Staffan Folestad, Mats Johansson, Anders Rasmuson
Publikováno v:
Powder Technology. 280:124-134
Particle cycle and residence time distributions in different regions, particularly in the spray zone, play an important role in fluid bed coating. In this study, a DEM-CFD (discrete element method, computational fluid dynamics) model is employed to d