Protein C/S ratio, an accurate and simple tool to identify carriers of a protein C gene mutation

Autor: Pieter-Jan De Kam, E.J. Libourel, Johan R. Meinardi, Jan van der Meer, Wim van der Schaaf, Marcel H. J. Ruiters, R. Veenstra

Publikováno v: British Journal of Haematology. 118:615-618

Hereditary protein C deficiency is demonstrated by lowered protein C plasma levels in a patient and at least one first-degree relative. This approach is insufficient in some cases owing to overlapping protein C levels in carriers and non-carriers of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::66b2fb85eb0a21844c63c5f8572dee41
https://doi.org/10.1046/j.1365-2141.2002.03597.x

Risk of venous thromboembolism in carriers of factor V Leiden with a concomitant inherited thrombophilic defect: a retrospective analysis

Autor: H. R. Büller, Saskia Middeldorp, Johan R. Meinardi, J van der Meer, E. C. M. Van Pampus, Martin H. Prins, Karly Hamulyák, Mmw Koopman, PJ de Kam

Publikováno v: Blood coagulation & fibrinolysis, 12(8), 713-720. Lippincott Williams and Wilkins
Blood Coagulation & Fibrinolysis, 12(8), 713-720

Factor V Leiden is the most common genetic defect associated with venous thromboembolism. Its clinical expression is limited and shows a wide intrafamilial and interfamilial variation, which might be explained by the influence of other genetic risk f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26e10123e79080537ea0a3860b09903c
https://doi.org/10.1097/00001721-200112000-00014

[Severe vitamin D deficiency and hypocalcaemia after bariatric surgery]

Autor: Harmke W, Korpershoek, Ellen M, Witteman, Johan R, Meinardi, E J Hans, Vollaard

Publikováno v: Nederlands tijdschrift voor geneeskunde. 154

A 60-year-old man was referred to the accident and emergency department because of muscle cramps and retrosternal pain. Laboratory tests revealed severe vitamin D deficiency and hypocalcaemia. The patient had undergone bariatric surgery several years

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8c0d061e086b5a0bcae30e417d2c3809
https://pubmed.ncbi.nlm.nih.gov/20132568

The incidence of recurrent venous thromboembolism in carriers of factor V Leiden is related to concomitant thrombophilic disorders

Autor: Johan R, Meinardi, Saskia, Middeldorp, Pieter J, de Kam, Maria M W, Koopman, Elisabeth C M, van Pampus, Karly, Hamulyák, Martin H, Prins, Harry R, Büller, Jan, van der Meer

Publikováno v: British journal of haematology. 116(3)

The duration of anticoagulant treatment after a first episode of venous thromboembolism primarily depends on the risk of recurrence. Variability of recurrence rates in factor (F) V Leiden carriers may be due to concomitant thrombophilic disorders. A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2d7db1fe414bcbd4cc70ac76e4a2782b
https://pubmed.ncbi.nlm.nih.gov/11849222

A Prospective Study of Asymptomatic Carriers of the Factor V Leiden Mutation To Determine the Incidence of Venous Thromboembolism

Autor: Johan R. Meinardi, Elisabeth C. M. Van Pampus, Martin H. Prins, Maria M. W. Koopman, Karly Hamulyák, Saskia Middeldorp, Harry R. Büller, Jan van der Meer

Publikováno v: Annals of Internal Medicine, 135(5), 322-327. AMER COLL PHYSICIANS
Annals of internal medicine, 135(5), 322-327. American College of Physicians

Background: The factor V Leiden mutation is a common genetic defect associated with an increased risk for venous thromboembolism. The clinical implications for asymptomatic carriers of this mutation and, consequently, the usefulness of screening fami

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84d50977f83298177955eae4d7d93355
https://doi.org/10.7326/0003-4819-135-5-200109040-00008