Zobrazeno 1 - 10
of 117
pro vyhledávání: '"Johan P, Turkenburg"'
Autor:
Rhianna J. Rowland, Svitlana Korolchuk, Marco Salamina, Natalie J. Tatum, James R. Ault, Sam Hart, Johan P. Turkenburg, James N. Blaza, Martin E. M. Noble, Jane A. Endicott
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract The cell division cycle 25 phosphatases CDC25A, B and C regulate cell cycle transitions by dephosphorylating residues in the conserved glycine-rich loop of CDKs to activate their activity. Here, we present the cryo-EM structure of CDK2-cycli
Externí odkaz:
https://doaj.org/article/7f9036edb0fb4c63978dfd51fe5e5873
Autor:
Olga V Moroz, Elena Blagova, Edward Taylor, Johan P Turkenburg, Lars K Skov, Garry P Gippert, Kirk M Schnorr, Li Ming, Liu Ye, Mikkel Klausen, Marianne T Cohn, Esben G W Schmidt, Søren Nymand-Grarup, Gideon J Davies, Keith S Wilson
Publikováno v:
PLoS ONE, Vol 16, Iss 3, p e0248190 (2021)
Muramidases/lysozymes hydrolyse the peptidoglycan component of the bacterial cell wall. They are found in many of the glycoside hydrolase (GH) families. Family GH25 contains muramidases/lysozymes, known as CH type lysozymes, as they were initially di
Externí odkaz:
https://doaj.org/article/d3c1f6391cf842f98c1cc16537ed4d9e
Autor:
Petra Dzianová, Seiya Asai, Martina Chrudinová, Lucie Kosinová, Pavlo Potalitsyn, Pavel Šácha, Romana Hadravová, Irena Selicharová, Jan Kříž, Johan P. Turkenburg, Andrzej Marek Brzozowski, Jiří Jiráček, Lenka Žáková
Publikováno v:
Open Biology, Vol 10, Iss 10 (2020)
Insulin is produced and stored inside the pancreatic β-cell secretory granules, where it is assumed to form Zn2+-stabilized oligomers. However, the actual storage forms of this hormone and the impact of zinc ions on insulin production in vivo are no
Externí odkaz:
https://doaj.org/article/cd3027437e574e159af8775f069f9003
Autor:
Shanshan Wu, Tam T.T.N. Nguyen, Olga V. Moroz, Johan P. Turkenburg, Jens E. Nielsen, Keith S. Wilson, Kasper D. Rand, Kaare Teilum
Publikováno v:
PeerJ, Vol 8, p e9408 (2020)
Background Several examples have emerged of enzymes where slow conformational changes are of key importance for function and where low populated conformations in the resting enzyme resemble the conformations of intermediate states in the catalytic pr
Externí odkaz:
https://doaj.org/article/38349b60495a4b6a9910ff94e5a0810f
Autor:
Nikolaj Kulahin Roed, Cristina M. Viola, Ole Kristensen, Gerd Schluckebier, Mathias Norrman, Waseem Sajid, John D. Wade, Asser Sloth Andersen, Claus Kristensen, Timothy R. Ganderton, Johan P. Turkenburg, Pierre De Meyts, Andrzej M. Brzozowski
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Insulin-like polypeptide binding proteins (IBPs) from insects can bind diverse insulin-like proteins (ILPs) including human insulin and IGFs. Here, the authors present structures of a Drosophila IBP in its free and ILP-bound forms, providing insights
Externí odkaz:
https://doaj.org/article/ab49da7df68b46db823e2dfac264e41c
Autor:
Laura C. Clark, Kate E. Atkin, Fiona Whelan, Andrew S. Brentnall, Gemma Harris, Aisling M. Towell, Johan P. Turkenburg, Yan Liu, Ten Feizi, Samuel C. Griffiths, Joan A. Geoghegan, Jennifer R. Potts
Staphylococcus aureus and Staphylococcus epidermidis are frequently associated with medical device infections that involve establishment of a bacterial biofilm on the device surface. Staphylococcal surface proteins Aap, SasG, and Pls are members of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f2eb7e8c4a424c63c4bb0e916418d50
http://hdl.handle.net/10044/1/102804
http://hdl.handle.net/10044/1/102804
Autor:
Adam M. Hughes, John F. Darby, Eleanor J. Dodson, Samuel J. Wilson, Johan P. Turkenburg, Gavin H. Thomas, Anthony J. Wilkinson
Publikováno v:
Microbiology. 168
Peptide transporters play important nutritional and cell signalling roles in Bacillus subtilis, which are pronounced during stationary phase adaptations and development. Three high-affinity ATP-binding cassette (ABC) family transporters are involved
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe0f6d2eba42ba7ee630cdaf52762e96
https://doi.org/10.1099/mic.0.001274
https://doi.org/10.1099/mic.0.001274
Autor:
William T. Ferreira, Jean L. Whittingham, James A. Brannigan, Simon M. Cutting, Shumpei Hanai, Johan P. Turkenburg, Anthony J. Wilkinson, Eleanor J. Dodson, Jared Cartwright
Publikováno v:
Acta Crystallographica. Section F, Structural Biology Communications
Clostridium difficile is a spore-forming bacterium and a leading cause of hospital-acquired antibiotic-associated diarrhoea. Symptoms of disease result from secreted toxins, while disease transmission is mediated via resistant endospores. CotE is a b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06df931b3a27f466b6aa023f4b6e5b00
https://doi.org/10.1107/s2053230x20006147
https://doi.org/10.1107/s2053230x20006147
Autor:
Gavin H. Thomas, Roderick E. Hubbard, Marcus Fischer, Johan P. Turkenburg, Shirley M. Roberts, Adam P. Hopkins, James A. Brannigan, John F. Darby, Seishi Shimizu
Publikováno v:
Journal of the American Chemical Society. 141:15818-15826
Solvent organization is a key but underexploited contributor to the thermodynamics of protein-ligand recognition, with implications for ligand discovery, drug resistance, and protein engineering. Here, we explore the contribution of solvent to ligand
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa7dff8fc3ae51a461a0aedb66a2bd14
https://doi.org/10.1021/jacs.9b06275
https://doi.org/10.1021/jacs.9b06275
Autor:
Edward J. Taylor, Lars K. Skov, Mikkel Klausen, Olga V. Moroz, Li Ming, Elena Blagova, G.P. Gippert, Liu Ye, Esben G. W. Schmidt, Kirk Matthew Schnorr, Marianne Thorup Cohn, Gideon J. Davies, Johan P. Turkenburg, Keith S. Wilson, Soren Nymand-Grarup
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 3, p e0248190 (2021)
PLoS ONE, Vol 16, Iss 3, p e0248190 (2021)
Muramidases/lysozymes hydrolyse the peptidoglycan component of the bacterial cell wall. They are found in many of the glycoside hydrolase (GH) families. Family GH25 contains muramidases/lysozymes, known as CH type lysozymes, as they were initially di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d96a33f4b9203bb26e2f4b5ed897c6b3
https://eprints.whiterose.ac.uk/172616/1/journal.pone.0248190.pdf
https://eprints.whiterose.ac.uk/172616/1/journal.pone.0248190.pdf