Subtype-specific responses of hKv7.4 and hKv7.5 channels to polyunsaturated fatty acids reveal an unconventional modulatory site and mechanism

Autor: Damon JA Frampton, Koushik Choudhury, Johan Nikesjö, Lucie Delemotte, Sara I Liin

Publikováno v: eLife, Vol 11 (2022)

The KV7.4 and KV7.5 subtypes of voltage-gated potassium channels play a role in important physiological processes such as sound amplification in the cochlea and adjusting vascular smooth muscle tone. Therefore, the mechanisms that regulate KV7.4 and

Externí odkaz: https://doaj.org/article/4a1c3bae62fd41169e4fabd9e94adbda

Subtype specific responses in hKv7.4 and hKv7.5 channels to polyunsaturated fatty acids

Autor: Johan Nikesjö, Sara I. Liin, Damon J. A. Frampton

The KV7.4 and KV7.5 subtypes of voltage-gated potassium channels are expressed in several tissues where they play a role in physiological processes such as sound amplification in the cochlea and adjusting vascular smooth muscle tone. Therefore, the m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cd0c89dad08be3b1ffd0590b131c1af1
https://doi.org/10.1101/2021.08.20.457075

Endocannabinoids enhance hKV7.1/KCNE1 channel function and shorten the cardiac action potential and QT interval

Autor: Irene Hiniesto-Iñigo, Laura M. Castro-Gonzalez, Valentina Corradi, Mark A. Skarsfeldt, Samira Yazdi, Siri Lundholm, Johan Nikesjö, Sergei Yu Noskov, Bo Hjorth Bentzen, D. Peter Tieleman, Sara I. Liin

Publikováno v: Hiniesto-Iñigo, I, Castro-Gonzalez, L M, Corradi, V, Skarsfeldt, M A, Yazdi, S, Lundholm, S, Nikesjö, J, Noskov, S Y, Bentzen, B H, Tieleman, D P & Liin, S I 2023, ' Endocannabinoids enhance hK V 7.1/KCNE1 channel function and shorten the cardiac action potential and QT interval ', EBioMedicine, vol. 89, 104459 . https://doi.org/10.1016/j.ebiom.2023.104459

Background Genotype-positive patients who suffer from the cardiac channelopathy Long QT Syndrome (LQTS) may display a spectrum of clinical phenotypes, with often unknown causes. Therefore, there is a need to identify factors influencing disease sever

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee9191c4c23a160d333e877731b087f4