Zobrazeno 1 - 10
of 442
pro vyhledávání: '"Johan M, Kros"'
Autor:
Rute M.S.M. Pedrosa, Johan M. Kros, Benjamin Schrijver, Cor Berrevoets, Rute B. Marques, Casper C.H.J. van Eijck, Reno Debets, PieterJ.M. Leenen, Willem A. Dik, DanaA.M. Mustafa
Publikováno v:
Heliyon, Vol 10, Iss 16, Pp e36598- (2024)
The appearance of brain metastasis is the most serious complication of breast cancer with mostly fatal outcomes. To reach the brain, tumor cells need to pass the blood-brain barrier (BBB). The molecular mechanisms underlying penetration of the BBB ar
Externí odkaz:
https://doaj.org/article/91b48a283cba4dc88e4fa1450d84f079
Autor:
Lara Andreoli, Catalina Berca, Sonja Katz, Maryna Korshevniuk, Ritchie M. Head, Kristel Van Steen, TranSYS Consortium, Kris Dierickx, Federico Melograna, Zuqi Li, Giada Lalli, Johan M. Kros, Shiva Najjary, Damjana Rozman, Andrew Walakira, Alexander Skupin, Elle Wilson, Francisco X. Real, Benno Schwikowski, Behnam Yousefi, Nataša Pržulj, Katarina Mihajlovic, Elisabeth B. Binder, Nahid Taheri, Anastasiia Hryhorzhevska, Lude Franke, George P. Patrinos, Kariofyllis Karamperis, Oscar Lao, Vitor A. P. Martins dos Santos, Christina Olsen, Ritchie Head
Publikováno v:
Frontiers in Medicine, Vol 11 (2024)
IntroductionIn the evolving healthcare landscape, precision medicine's rise necessitates adaptable doctoral training. The European Union has recognized this and promotes the development of international, training-focused programmes called Innovative
Externí odkaz:
https://doaj.org/article/33e1667ff3424246bdd333e44becb2c0
Autor:
Shiva Najjary, Johan M. Kros, Bruno H. Stricker, Rikje Ruiter, Yu Shuai, Robert Kraaij, Kristel Van Steen, Peter van derSpek, Casper H. J. Van Eijck, M. Arfan Ikram, Shahzad Ahmad
Publikováno v:
Cancer Medicine, Vol 13, Iss 3, Pp n/a-n/a (2024)
Abstract The immune response–gut microbiota interaction is implicated in various human diseases, including cancer. Identifying the link between the gut microbiota and systemic inflammatory markers and their association with cancer will be important
Externí odkaz:
https://doaj.org/article/5c6d3b511d7247668c577ceb0cb7ec86
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionThe incidence of brain metastases in cancer patients is increasing, with lung and breast cancer being the most common sources. Despite advancements in targeted therapies, the prognosis remains poor, highlighting the importance to investig
Externí odkaz:
https://doaj.org/article/270604d075a549e693cb32fb468421f8
Autor:
Shiva Najjary, Johan M. Kros, Willem de Koning, Disha Vadgama, Karishma Lila, Janina Wolf, Dana A. M. Mustafa
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-12 (2023)
Abstract Metastases in the brain are the most severe and devastating complication of cancer. The incidence of brain metastasis is increasing. Therefore, the need of finding specific druggable targets for brain metastasis is demanding. The aim of this
Externí odkaz:
https://doaj.org/article/e95eb251c5384fe3ae7a61741557fb1d
Autor:
Patryk Skowron, Hamza Farooq, Florence M. G. Cavalli, A. Sorana Morrissy, Michelle Ly, Liam D. Hendrikse, Evan Y. Wang, Haig Djambazian, Helen Zhu, Karen L. Mungall, Quang M. Trinh, Tina Zheng, Shizhong Dai, Ana S. Guerreiro Stucklin, Maria C. Vladoiu, Vernon Fong, Borja L. Holgado, Carolina Nor, Xiaochong Wu, Diala Abd-Rabbo, Pierre Bérubé, Yu Chang Wang, Betty Luu, Raul A. Suarez, Avesta Rastan, Aaron H. Gillmor, John J. Y. Lee, Xiao Yun Zhang, Craig Daniels, Peter Dirks, David Malkin, Eric Bouffet, Uri Tabori, James Loukides, François P. Doz, Franck Bourdeaut, Olivier O. Delattre, Julien Masliah-Planchon, Olivier Ayrault, Seung-Ki Kim, David Meyronet, Wieslawa A. Grajkowska, Carlos G. Carlotti, Carmen de Torres, Jaume Mora, Charles G. Eberhart, Erwin G. Van Meir, Toshihiro Kumabe, Pim J. French, Johan M. Kros, Nada Jabado, Boleslaw Lach, Ian F. Pollack, Ronald L. Hamilton, Amulya A. Nageswara Rao, Caterina Giannini, James M. Olson, László Bognár, Almos Klekner, Karel Zitterbart, Joanna J. Phillips, Reid C. Thompson, Michael K. Cooper, Joshua B. Rubin, Linda M. Liau, Miklós Garami, Peter Hauser, Kay Ka Wai Li, Ho-Keung Ng, Wai Sang Poon, G. Yancey Gillespie, Jennifer A. Chan, Shin Jung, Roger E. McLendon, Eric M. Thompson, David Zagzag, Rajeev Vibhakar, Young Shin Ra, Maria Luisa Garre, Ulrich Schüller, Tomoko Shofuda, Claudia C. Faria, Enrique López-Aguilar, Gelareh Zadeh, Chi-Chung Hui, Vijay Ramaswamy, Swneke D. Bailey, Steven J. Jones, Andrew J. Mungall, Richard A. Moore, John A. Calarco, Lincoln D. Stein, Gary D. Bader, Jüri Reimand, Jiannis Ragoussis, William A. Weiss, Marco A. Marra, Hiromichi Suzuki, Michael D. Taylor
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Sonic Hedgehog medulloblastoma (Shh-MB) comprises four subtypes each with distinct clinical traits. Here the authors characterize the genome, transcriptome, and methylome of Shh-MB subtypes, revealing a complex fusion landscape and the molecular conv
Externí odkaz:
https://doaj.org/article/091429a4162845e7a18371f487596c6f
Autor:
Cynthia B. deMedeiros, Iska Moxon‐Emre, Nadia Scantlebury, David Malkin, Vijay Ramaswamy, Alexandra Decker, Nicole Law, Toshihiro Kumabe, Jeffrey Leonard, Josh Rubin, Shin Jung, Seung‐Ki Kim, Nalin Gupta, William Weiss, Claudia C. Faria, Rajeev Vibhakar, Lucie Lafay‐Cousin, Jennifer Chan, Johan M. Kros, Laura Janzen, Michael D. Taylor, Eric Bouffet, Donald J. Mabbott
Publikováno v:
Cancer Medicine, Vol 9, Iss 2, Pp 447-459 (2020)
Abstract Background Understanding the global impact of medulloblastoma on health related quality of life (HRQL) is critical to characterizing the broad impact of this disease and realizing the benefits of modern treatments. We evaluated HRQL in an in
Externí odkaz:
https://doaj.org/article/d8e33d8b17a543f29c90497a4da7b332
Autor:
Bas Weenink, Kaspar Draaisma, Han Z. Ooi, Johan M. Kros, Peter A. E. Sillevis Smitt, Reno Debets, Pim J. French
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Abstract In multiple tumor types, prediction of response to immune therapies relates to the presence, distribution and activation state of tumor infiltrating lymphocytes (TILs). Although such therapies are, to date, unsuccessful in gliomas, little is
Externí odkaz:
https://doaj.org/article/8d69b7caf1204a69af1c62b11ef298e8
Autor:
Lona Zeneyedpour, Christoph Stingl, Johan M. Kros, Peter A. E. Sillevis Smitt, Theo M. Luider
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 9, p 5061 (2022)
We investigated the feasibility of detecting the presence of specific autoantibodies against potential tumor-associated peptide antigens by enriching these antibody–peptide complexes using Melon Gel resin and mass spectrometry. Our goal was to find
Externí odkaz:
https://doaj.org/article/f703dc6c4ec249d3a8b2a83db74bb99c
Autor:
Nathalie E. Synhaeve, Martin J. van den Bent, Pim J. French, Winand N. M. Dinjens, Peggy N. Atmodimedjo, Johan M. Kros, R. Verdijk, Clemens M. F. Dirven, Hendrikus J. Dubbink
Publikováno v:
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-8 (2018)
Abstract Since 2013 next-generation sequencing (NGS) targeting genes mutated in diffuse gliomas is part of routine diagnostics in our institute. In the present report, we evaluate the use of this custom tailored NGS platform on 434 samples. The NGS p
Externí odkaz:
https://doaj.org/article/e8b2b09606294934bb599dc8e7c35f61