Zobrazeno 1 - 10
of 6 435
pro vyhledávání: '"Johan M"'
Autor:
Rute M.S.M. Pedrosa, Johan M. Kros, Benjamin Schrijver, Cor Berrevoets, Rute B. Marques, Casper C.H.J. van Eijck, Reno Debets, PieterJ.M. Leenen, Willem A. Dik, DanaA.M. Mustafa
Publikováno v:
Heliyon, Vol 10, Iss 16, Pp e36598- (2024)
The appearance of brain metastasis is the most serious complication of breast cancer with mostly fatal outcomes. To reach the brain, tumor cells need to pass the blood-brain barrier (BBB). The molecular mechanisms underlying penetration of the BBB ar
Externí odkaz:
https://doaj.org/article/91b48a283cba4dc88e4fa1450d84f079
Autor:
Ward Vanthienen, Juan Fernández-García, Maria Francesca Baietti, Elisa Claeys, Frederik Van Leemputte, Long Nguyen, Vera Goossens, Quinten Deparis, Dorien Broekaert, Sophie Vlayen, Dominique Audenaert, Michel Delforge, Alessandro D’Amuri, Griet Van Zeebroeck, Eleonora Leucci, Sarah-Maria Fendt, Johan M. Thevelein
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
Many cancer cells share with yeast a preference for fermentation over respiration, which is associated with overactive glucose uptake and breakdown, a phenomenon called the Warburg effect in cancer cells. The yeast tps1Δ mutant shows even more prono
Externí odkaz:
https://doaj.org/article/a8c6508b076646c7a024f4d85755eb93
Autor:
Johan M. Strijdom
Publikováno v:
Journal for the Study of Religion, Vol 37, Iss 1, Pp 1-14 (2024)
This article addresses the fundamental question of how knowledge about religion is acquired in the academic study of religion. It does so by means of a comparison of the answers to the question by Emile Durkheim and David Chidester. Durkheim, in enga
Externí odkaz:
https://doaj.org/article/54db1e96e08f4a95911d53d143e28af6
Publikováno v:
Verbum et Ecclesia, Vol 45, Iss 1, Pp e1-e7 (2024)
Church discipline: embarrassment or a new opportunity? In 2004, 2007 and 2011 the General Synod of the Dutch Reformed Church decided that the way in which church discipline functions in the church, should be researched and investigated. This article
Externí odkaz:
https://doaj.org/article/837236d9478e4111ababf12d96687a4c
Autor:
Lara Andreoli, Catalina Berca, Sonja Katz, Maryna Korshevniuk, Ritchie M. Head, Kristel Van Steen, TranSYS Consortium, Kris Dierickx, Federico Melograna, Zuqi Li, Giada Lalli, Johan M. Kros, Shiva Najjary, Damjana Rozman, Andrew Walakira, Alexander Skupin, Elle Wilson, Francisco X. Real, Benno Schwikowski, Behnam Yousefi, Nataša Pržulj, Katarina Mihajlovic, Elisabeth B. Binder, Nahid Taheri, Anastasiia Hryhorzhevska, Lude Franke, George P. Patrinos, Kariofyllis Karamperis, Oscar Lao, Vitor A. P. Martins dos Santos, Christina Olsen, Ritchie Head
Publikováno v:
Frontiers in Medicine, Vol 11 (2024)
IntroductionIn the evolving healthcare landscape, precision medicine's rise necessitates adaptable doctoral training. The European Union has recognized this and promotes the development of international, training-focused programmes called Innovative
Externí odkaz:
https://doaj.org/article/33e1667ff3424246bdd333e44becb2c0
Autor:
Shiva Najjary, Johan M. Kros, Bruno H. Stricker, Rikje Ruiter, Yu Shuai, Robert Kraaij, Kristel Van Steen, Peter van derSpek, Casper H. J. Van Eijck, M. Arfan Ikram, Shahzad Ahmad
Publikováno v:
Cancer Medicine, Vol 13, Iss 3, Pp n/a-n/a (2024)
Abstract The immune response–gut microbiota interaction is implicated in various human diseases, including cancer. Identifying the link between the gut microbiota and systemic inflammatory markers and their association with cancer will be important
Externí odkaz:
https://doaj.org/article/5c6d3b511d7247668c577ceb0cb7ec86
Autor:
Shiva Najjary, Johan M. Kros, Willem de Koning, Disha Vadgama, Karishma Lila, Janina Wolf, Dana A. M. Mustafa
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-12 (2023)
Abstract Metastases in the brain are the most severe and devastating complication of cancer. The incidence of brain metastasis is increasing. Therefore, the need of finding specific druggable targets for brain metastasis is demanding. The aim of this
Externí odkaz:
https://doaj.org/article/e95eb251c5384fe3ae7a61741557fb1d
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionThe incidence of brain metastases in cancer patients is increasing, with lung and breast cancer being the most common sources. Despite advancements in targeted therapies, the prognosis remains poor, highlighting the importance to investig
Externí odkaz:
https://doaj.org/article/270604d075a549e693cb32fb468421f8
Autor:
Birgit S. Geurts, Thomas W. Battaglia, J. Maxime van Berge Henegouwen, Laurien J. Zeverijn, Gijs F. de Wit, Louisa R. Hoes, Hanneke van der Wijngaart, Vincent van der Noort, Paul Roepman, Wendy W. J. de Leng, Anne M. L. Jansen, Frans L. Opdam, Maja J. A. de Jonge, Geert A. Cirkel, Mariette Labots, Ann Hoeben, Emile D. Kerver, Adriaan D. Bins, Frans G.L. Erdkamp, Johan M. van Rooijen, Danny Houtsma, Mathijs P. Hendriks, Jan-Willem B. de Groot, Henk M. W. Verheul, Hans Gelderblom, Emile E. Voest
Publikováno v:
BMC Cancer, Vol 23, Iss 1, Pp 1-14 (2023)
Abstract Background In this study we aimed to evaluate the efficacy and safety of the PD-L1 inhibitor durvalumab across various mismatch repair deficient (dMMR) or microsatellite instability-high (MSI-H) tumours in the Drug Rediscovery Protocol (DRUP
Externí odkaz:
https://doaj.org/article/0e6af27c660548eab8d0d86d81fe251d
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 19, Iss 1, Pp 115-132 (2023)
This review covers the synthetic applications of 1,4-dithianes, as well as derivatives thereof at various oxidation states. The selected examples show how the specific heterocyclic reactivity can be harnessed for the controlled synthesis of carbon–
Externí odkaz:
https://doaj.org/article/4c27f2c4ffe54a4fa1510728218f9c54