Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Johan Lundkvist"'
Autor:
Yachao He, Ibrahim Kaya, Reza Shariatgorji, Johan Lundkvist, Lars U. Wahlberg, Anna Nilsson, Dejan Mamula, Jan Kehr, Justyna Zareba-Paslawska, Henrik Biverstål, Karima Chergui, Xiaoqun Zhang, Per E. Andren, Per Svenningsson
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)
Abstract Prosaposin (PSAP) modulates glycosphingolipid metabolism and variants have been linked to Parkinson’s disease (PD). Here, we find altered PSAP levels in the plasma, CSF and post-mortem brain of PD patients. Altered plasma and CSF PSAP leve
Externí odkaz:
https://doaj.org/article/bbdd1f902a3a439685091307419305e5
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
Recent clinical data with three therapeutic anti-Aβ antibodies have demonstrated that removal of Aβ-amyloid plaques in early Alzheimer's disease (AD) can attenuate disease progression. This ground-breaking progress in AD medicine has validated both
Externí odkaz:
https://doaj.org/article/02712783120143b5841629e85e753962
Autor:
Daniel V Oliveira, Kirsten G Coupland, Wenchao Shao, Shaobo Jin, Francesca Del Gaudio, Sailan Wang, Rhys Fox, Julie W Rutten, Johan Sandin, Henrik Zetterberg, Johan Lundkvist, Saskia AJ Lesnik Oberstein, Urban Lendahl, Helena Karlström
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 2, Pp n/a-n/a (2023)
Abstract Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common monogenic form of familial small vessel disease; no preventive or curative therapy is available. CADASIL is caused by mut
Externí odkaz:
https://doaj.org/article/68d5b97efac9440abb6b6bcfdeb077ea
Autor:
Johanna Wanngren, Patricia Lara, Karin Öjemalm, Silvia Maioli, Nasim Moradi, Lu Chen, Lars O. Tjernberg, Johan Lundkvist, IngMarie Nilsson, Helena Karlström
Publikováno v:
FEBS Open Bio, Vol 4, Iss C, Pp 393-406 (2014)
The enzyme complex γ-secretase generates amyloid β-peptide (Aβ), a 37–43-residue peptide associated with Alzheimer disease (AD). Mutations in presenilin 1 (PS1), the catalytical subunit of γ-secretase, result in familial AD (FAD). A unifying th
Externí odkaz:
https://doaj.org/article/d575a72492234136bf2c6d4143b2d91f
Autor:
Niklas Mattsson, Lawrence Rajendran, Henrik Zetterberg, Mikael Gustavsson, Ulf Andreasson, Maria Olsson, Gunnar Brinkmalm, Johan Lundkvist, Laura H Jacobson, Ludovic Perrot, Ulf Neumann, Herman Borghys, Marc Mercken, Deborah Dhuyvetter, Fredrik Jeppsson, Kaj Blennow, Erik Portelius
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e31084 (2012)
BACE1 is a key enzyme for amyloid-β (Aβ) production, and an attractive therapeutic target in Alzheimer's disease (AD). Here we report that BACE1 inhibitors have distinct effects on neuronal Aβ metabolism, inducing a unique pattern of secreted Aβ
Externí odkaz:
https://doaj.org/article/820b53e8ca3c4c7fb2421581da40bd31
Autor:
Tina Arndt, Urmimala Chatterjee, Olga Shilkova, Juanita Francis, Johan Lundkvist, Daniel Johansson, Benjamin Schmuck, Gabriele Greco, Åsa Ekblad Nordberg, Yan Li, Lars U Wahlberg, Maud Langton, Jan Johansson, Cecilia Götherström, Anna Rising
Publikováno v:
Advanced Functional Materials.
Autor:
Daniel V Oliveira, Kirsten G Coupland, Wenchao Shao, Shaobo Jin, Francesca Del Gaudio, Sailan Wang, Rhys Fox, Julie W Rutten, Johan Sandin, Henrik Zetterberg, Johan Lundkvist, Saskia AJ Lesnik Oberstein, Urban Lendahl, Helena Karlström
Publikováno v:
EMBO Molecular Medicine. WILEY
EMBO Molecular Medicine
EMBO Molecular Medicine
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common monogenic form of familial small vessel disease; no preventive or curative therapy is available. CADASIL is caused by mutations in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7916532e5e5d16946f42b074f09cee3c
https://hdl.handle.net/1887/3566779
https://hdl.handle.net/1887/3566779
Autor:
Daniel V. Oliveira, Kirsten G. Coupland, Shaobo Jin, Francesca Del Gaudio, Sailan Wang, Rhys Fox, Julie W. Rutten, Johan Sandin, Johan Lundkvist, Saskia A. J. Lesnik Oberstein, Urban Lendahl, Helena Karlström
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common monogenic form of familial small vessel disease and no preventive or curative therapy is available. CADASIL is caused by mutations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::33d0f802322c9d1411737e0f930e5576
https://doi.org/10.1101/2022.07.11.499563
https://doi.org/10.1101/2022.07.11.499563
Autor:
Tobias A. Weber, Johan Lundkvist, Johanna Wanngren, Hlin Kvartsberg, ShaoBo Jin, Pia Larssen, Dan Wu, Daniel V. Oliveira, Karolina Minta, Gunnar Brinkmalm, Henrik Zetterberg, Kaj Blennow, Gunnar Nordvall, Bengt Winblad, Erik Portelius, Helena Karlström
Publikováno v:
Journal of cellular and molecular medicine. 26(3)
The aggregation of β-amyloid peptide 42 results in the formation of toxic oligomers and plaques, which plays a pivotal role in Alzheimer's disease pathogenesis. Aβ42 is one of several Aβ peptides, all of Aβ30 to Aβ43 that are produced as a resul
Autor:
Frauke Ackermann, Joshua A. Gregory, Shaohua Xu, Johan Lundkvist, Saket M. Nigam, Urban Lendahl, Lennart Brodin
Publikováno v:
Neuroscience research 109, 9-15 (2016). doi:10.1016/j.neures.2016.02.002
BACE1-mediated cleavage of APP is a pivotal step in the production of the Alzheimer related Aβ peptide and inhibitors of BACE1 are currently in clinical development for the treatment of Alzheimer disease (AD). While processing and trafficking of APP