Výsledky vyhledávání

Akademický článek

Chondroitin/dermatan sulfate glycosyltransferase genes are essential for craniofacial development.

Autor: Judith Habicher, Gaurav K Varshney, Laura Waldmann, Daniel Snitting, Amin Allalou, Hanqing Zhang, Abdurrahman Ghanem, Caroline Öhman Mägi, Tabea Dierker, Lena Kjellén, Shawn M Burgess, Johan Ledin

Publikováno v: PLoS Genetics, Vol 18, Iss 2, p e1010067 (2022)

Chondroitin/dermatan sulfate (CS/DS) proteoglycans are indispensable for animal development and homeostasis but the large number of enzymes involved in their biosynthesis have made CS/DS function a challenging problem to study genetically. In our stu

Externí odkaz: https://doaj.org/article/14829a228b8e40ef9f46f01aa8efbb7b

Zobrazit plný text záznamu

Plný text ve formátu HTML

Akademický článek

The NDST gene family in zebrafish: role of NDST1B in pharyngeal arch formation.

Autor: Beata Filipek-Górniok, Pernilla Carlsson, Tatjana Haitina, Judith Habicher, Johan Ledin, Lena Kjellén

Publikováno v: PLoS ONE, Vol 10, Iss 3, p e0119040 (2015)

Heparan sulfate (HS) proteoglycans are ubiquitous components of the extracellular matrix and plasma membrane of metazoans. The sulfation pattern of the HS glycosaminoglycan chain is characteristic for each tissue and changes during development. The g

Externí odkaz: https://doaj.org/article/ff28671a8ef940f784cd6fe0d0dfe879

Zobrazit plný text záznamu

Akademický článek

Chondroitin / dermatan sulfate modification enzymes in zebrafish development.

Autor: Judith Habicher, Tatjana Haitina, Inger Eriksson, Katarina Holmborn, Tabea Dierker, Per E Ahlberg, Johan Ledin

Publikováno v: PLoS ONE, Vol 10, Iss 3, p e0121957 (2015)

Chondroitin/dermatan sulfate (CS/DS) proteoglycans consist of unbranched sulfated polysaccharide chains of repeating GalNAc-GlcA/IdoA disaccharide units, attached to serine residues on specific proteins. The CS/DS proteoglycans are abundant in the ex

Externí odkaz: https://doaj.org/article/2afd56c138f4412b83f708e1603897a0

Zobrazit plný text záznamu

Akademický článek

Spinal deformity in aged zebrafish is accompanied by degenerative changes to their vertebrae that resemble osteoarthritis.

Autor: Anthony J Hayes, Scott Reynolds, Mari A Nowell, Lee B Meakin, Judith Habicher, Johan Ledin, Andrew Bashford, Bruce Caterson, Chrissy L Hammond

Publikováno v: PLoS ONE, Vol 8, Iss 9, p e75787 (2013)

Age-related degenerative changes within the vertebral column are a significant cause of morbidity with considerable socio-economic impact worldwide. An improved understanding of these changes through the development of experimental models may lead to

Externí odkaz: https://doaj.org/article/f87e45dcbe6c436c80cb58e1a8b331c6

Zobrazit plný text záznamu

Proteoglycans in Zebrafish Development

Autor: Johan Ledin, Beata Filipek-Górniok, Lena Kjellén, Judith Habicher

Publikováno v: Proteoglycans in Stem Cells ISBN: 9783030734527

Forward genetic screens have identified several zebrafish mutants related to glycosaminoglycan biosynthesis with developmental defects. Many important studies have also used morpholino knockdown of gene expression for functional studies, but off-targ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b66bff8627a0578055de9b6be7812bd9
https://doi.org/10.1007/978-3-030-73453-4_2

Zobrazit plný text záznamu

Heparan Sulfate Biosynthesis in Zebrafish

Autor: Judith Habicher, Lena Kjellén, Beata Filipek-Górniok, Johan Ledin

Publikováno v: J Histochem Cytochem

The biosynthesis of heparan sulfate (HS) proteoglycans occurs in the Golgi compartment of cells and will determine the sulfation pattern of HS chains, which in turn will have a large impact on the biological activity of the proteoglycans. Earlier stu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64c0fd95e9d10319bbcf4f4118510486
https://pubmed.ncbi.nlm.nih.gov/33216642

Zobrazit plný text záznamu

Amyloid precursor protein-b facilitates cell adhesion during early development in zebrafish

Autor: Johan Ledin, Henrik Zetterberg, Gaurav K. Varshney, Jasmine Chebli, Rafael Camacho, Tugce Munise Satir, Shawn M. Burgess, Rakesh Kumar Banote, Alexandra Abramsson

Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)
Scientific Reports

Understanding the biological function of amyloid beta (Aβ) precursor protein (APP) beyond its role in Alzheimer’s disease is emerging. Yet, its function during embryonic development is poorly understood. The zebrafish APP homologue, Appb, is stron

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0677b3d9d89f0392a31efd1280946168
https://doi.org/10.1038/s41598-020-66584-8

Zobrazit plný text záznamu

Targeted Editing of Zebrafish Genes to Understand Gene Function and Human Disease Pathology

Autor: Shawn M. Burgess, Alberto Rissone, Johan Ledin

Researchers often attempt to understand biological phenomena, particularly disease pathology, in an organism by manipulating a biological process to observe and interpret the effects. Although human diseases have mostly been modeled in mice, in the l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::60cb02ee08c01c080710b47084d1149e
https://doi.org/10.1016/b978-0-12-812431-4.00049-x

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání